دورية أكاديمية
أعرض في EDS

Lesion size is associated with genetic polymorphisms in TLR1, TLR6, and TIRAP genes in patients with major abscesses and diabetic foot infections.

التفاصيل البيبلوغرافية
العنوان: Lesion size is associated with genetic polymorphisms in TLR1, TLR6, and TIRAP genes in patients with major abscesses and diabetic foot infections.
المؤلفون: D'Onofrio V; Faculty of Medicine and Life Sciences, Research Group of Immunology and Biochemistry, Hasselt University, Hasselt, Belgium.; Department of Infectious Diseases and Immunity, Jessa Hospital, Hasselt, Belgium.; Department of Internal Medicine and Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands., Monnier AA; Faculty of Medicine and Life Sciences, Research Group of Immunology and Biochemistry, Hasselt University, Hasselt, Belgium.; Department of Internal Medicine and Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands., Kremer C; Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Hasselt, Belgium., Stappers MHT; Department of Internal Medicine and Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Biosciences, Geoffrey Pope Building, University of Exeter, Stocker Road, Exeter, EX4 4QD, UK., Netea MG; Department of Internal Medicine and Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.; Human Genomics Laboratory, Craiova University of Medicine and Pharmacy, Craiova, Romania., Gyssens IC; Faculty of Medicine and Life Sciences, Research Group of Immunology and Biochemistry, Hasselt University, Hasselt, Belgium. inge.gyssens@radboudumc.nl.; Department of Internal Medicine and Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands. inge.gyssens@radboudumc.nl.
المصدر: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [Eur J Clin Microbiol Infect Dis] 2020 Feb; Vol. 39 (2), pp. 353-360. Date of Electronic Publication: 2019 Nov 30.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 8804297 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-4373 (Electronic) Linking ISSN: 09349723 NLM ISO Abbreviation: Eur J Clin Microbiol Infect Dis Subsets: MEDLINE
أسماء مطبوعة: Publication: Berlin : Springer
Original Publication: [Wiesbaden, Federal Republic of Germany] : Vieweg, [c1988-
مواضيع طبية MeSH: Genetic Predisposition to Disease* , Polymorphism, Single Nucleotide*, Abscess/*etiology , Diabetic Foot/*etiology , Membrane Glycoproteins/*genetics , Receptors, Interleukin-1/*genetics , Toll-Like Receptor 1/*genetics , Toll-Like Receptor 6/*genetics, Abscess/diagnosis ; Adult ; Aged ; Alleles ; Comorbidity ; Diabetic Foot/diagnosis ; Disease Susceptibility/immunology ; Female ; Genetic Association Studies ; Genotype ; Humans ; Male ; Middle Aged
مستخلص: Genetic variation in Toll-like receptors (TLRs) has previously been associated with susceptibility to complicated skin and skin structure infections (cSSSIs). The aim of this study was to investigate associations between the severity of cSSSIs, i.e., major abscesses and diabetic foot infections (DFIs), and a set of genetic polymorphisms in the Toll-like receptor pathway. A total of 121 patients with major abscesses and 132 with DFIs participating in a randomized clinical trial were genotyped for 13 nonsynonymous single-nucleotide polymorphisms (SNPs) in genes coding for TLRs and the signaling adaptor molecule TIRAP. Infection severity was defined by lesion size at clinical presentation for both types of infections. The PEDIS infection score was also used to define severity of DFIs. Linear regression models were used to study factors independently associated with severity. In patients with large abscesses, hetero- or homozygosity for the allelic variant TLR6 (P249S) was associated with significantly smaller lesions while homozygosity for the allelic variant TLR1 (R80T) was associated with significantly larger lesions. PRRs genes were not significantly associated with PEDIS. However, patients with DFI hetero- or homozygous for the allelic variant TLR1 (S248N) had significantly larger lesions. Polymorphisms in TLR1 and TLR6 influence the severity of cSSSIs as assessed by the lesion size of major abscesses and DFIs. ClinicalTrial.gov Identifier: NCT00402727.
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فهرسة مساهمة: Keywords: Abscess; Diabetic foot infection; Innate immunity; Pattern recognition receptors; Single-nucleotide polymorphism
سلسلة جزيئية: ClinicalTrials.gov NCT00402727
المشرفين على المادة: 0 (Membrane Glycoproteins)
0 (Receptors, Interleukin-1)
0 (TIRAP protein, human)
0 (TLR1 protein, human)
0 (TLR6 protein, human)
0 (Toll-Like Receptor 1)
0 (Toll-Like Receptor 6)
تواريخ الأحداث: Date Created: 20191202 Date Completed: 20201005 Latest Revision: 20210907
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7010613
DOI: 10.1007/s10096-019-03732-7
PMID: 31786695
قاعدة البيانات: MEDLINE
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