دورية أكاديمية
أعرض في EDS

Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth.

التفاصيل البيبلوغرافية
العنوان: Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth.
المؤلفون: Cowan JE; Laboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Malin J; Laboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Zhao Y; Laboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Seedhom MO; Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Harly C; Laboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Ohigashi I; Division of Experimental Immunology, Institute of Advanced Medical Sciences, University of Tokushima, Tokushima, 770-8503, Japan., Kelly M; Single Cell Analysis Facility, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Takahama Y; Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Yewdell JW; Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Cam M; Office of Science and Technology Resources, Office of the Director, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Bhandoola A; Laboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA. avinash.bhandoola@nih.gov.
المصدر: Nature communications [Nat Commun] 2019 Dec 02; Vol. 10 (1), pp. 5498. Date of Electronic Publication: 2019 Dec 02.
نوع المنشور: Journal Article; Research Support, N.I.H., Intramural
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Transcription, Genetic*, Epithelial Cells/*metabolism , Oncogene Protein p55(v-myc)/*metabolism , Thymus Gland/*embryology, Animals ; Epithelial Cells/cytology ; Female ; Gene Expression Regulation, Developmental ; Humans ; Male ; Mice ; Mice, Transgenic ; Oncogene Protein p55(v-myc)/genetics ; Organ Size ; Organogenesis ; Thymus Gland/metabolism
مستخلص: Interactions between thymic epithelial cells (TEC) and developing thymocytes are essential for T cell development, but molecular insights on TEC and thymus homeostasis are still lacking. Here we identify distinct transcriptional programs of TEC that account for their age-specific properties, including proliferation rates, engraftability and function. Further analyses identify Myc as a regulator of fetal thymus development to support the rapid increase of thymus size during fetal life. Enforced Myc expression in TEC induces the prolonged maintenance of a fetal-specific transcriptional program, which in turn extends the growth phase of the thymus and enhances thymic output; meanwhile, inducible expression of Myc in adult TEC similarly promotes thymic growth. Mechanistically, this Myc function is associated with enhanced ribosomal biogenesis in TEC. Our study thus identifies age-specific transcriptional programs in TEC, and establishes that Myc controls thymus size.
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معلومات مُعتمدة: ZIA BC011633 United States ImNIH Intramural NIH HHS
المشرفين على المادة: 0 (Oncogene Protein p55(v-myc))
تواريخ الأحداث: Date Created: 20191204 Date Completed: 20200304 Latest Revision: 20240422
رمز التحديث: 20240422
مُعرف محوري في PubMed: PMC6889275
DOI: 10.1038/s41467-019-13465-y
PMID: 31792212
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-019-13465-y