دورية أكاديمية
Effects of physical exercise on skeletal muscles of rats with cerebral ischemia.
| العنوان: | Effects of physical exercise on skeletal muscles of rats with cerebral ischemia. |
|---|---|
| المؤلفون: | Melo RTR; Departamento de Biologia Celular e Estrutural, Universidade Federal de Viçosa, Viçosa, MG, Brasil., Damázio LCM; Departamento de Medicina, Universidade Federal de São João del-Rei, São João del-Rei, MG, Brasil., Lima MC; Departamento de Morfologia, Universidade Federal de São João del-Rei, Divinópolis, MG, Brasil., Pereira VG; Departamento de Medicina Veterinária, Universidade Federal de Viçosa, Viçosa, MG, Brasil., Okano BS; Departamento de Medicina Veterinária, Universidade Federal de Viçosa, Viçosa, MG, Brasil., Monteiro BS; Departamento de Medicina Veterinária, Universidade Federal de Viçosa, Viçosa, MG, Brasil., Natali AJ; Departamento de Educação Física, Universidade Federal de Viçosa, Viçosa, MG, Brasil., Carlo RJD; Departamento de Medicina Veterinária, Universidade Federal de Viçosa, Viçosa, MG, Brasil., Maldonado IRSC; Departamento de Biologia Celular e Estrutural, Universidade Federal de Viçosa, Viçosa, MG, Brasil. |
| المصدر: | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas [Braz J Med Biol Res] 2019 Nov 28; Vol. 52 (12), pp. e8576. Date of Electronic Publication: 2019 Nov 28 (Print Publication: 2019). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Associação Brasileira de Divulgação Científica Country of Publication: Brazil NLM ID: 8112917 Publication Model: eCollection Cited Medium: Internet ISSN: 1414-431X (Electronic) Linking ISSN: 0100879X NLM ISO Abbreviation: Braz J Med Biol Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [SP, Brasil : Associação Brasileira de Divulgação Científica, 1981- |
| مواضيع طبية MeSH: | Infarction, Middle Cerebral Artery*, Brain Ischemia/*complications , Muscle, Skeletal/*physiopathology , Muscular Atrophy/*prevention & control , Physical Conditioning, Animal/*physiology, Animals ; Brain Ischemia/physiopathology ; Disease Models, Animal ; Male ; Muscular Atrophy/etiology ; Muscular Atrophy/pathology ; Rats ; Rats, Wistar |
| مستخلص: | Physical exercise is a known preventive and therapeutic alternative for several cerebrovascular diseases. Therefore, the objective of the present study was to evaluate the motor performance and histomorphometry of the biceps brachii, soleus, and tibialis anterior muscles of rats submitted to a treadmill training program prior to the induction of cerebral ischemia via occlusion of the middle cerebral artery (OMCA). A total of 24 Wistar rats were distributed into four groups: Sham-Sed: sedentary control animals (n=6), who underwent sham surgery (in which OMCA did not occur); Sham+Ex: control animals exercised before the sham surgery (n=6); I-Sed: sedentary animals with cerebral ischemia (n=6); and I+Ex: animals exercised before the induction of ischemia (n=6). The physical exercise consisted of treadmill training for five weeks, 30 min/day (5 days/week), at a speed of 14 m/min. The results showed that the type-I fibers presented greater fiber area in the exercised ischemic group (I+Ex: 2347.96±202.77 µm2) compared to the other groups (Sham-Sed: 1676.46±132.21 µm2; Sham+Ex: 1647.63±191.09 µm2; I+Ex: 1566.93±185.09 µm2; P=0.0002). Our findings suggested that the angiogenesis process may have influenced muscle recovery and reduced muscle atrophy of type-I fibers in the animals that exercised before cerebral ischemia. |
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| تواريخ الأحداث: | Date Created: 20191205 Date Completed: 20200122 Latest Revision: 20231020 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC6886361 |
| DOI: | 10.1590/1414-431X20198576 |
| PMID: | 31800730 |
| قاعدة البيانات: | MEDLINE |
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