دورية أكاديمية
أعرض في EDS

Vitamin B 12 Deficiency and Foot Ulcers in Type 2 Diabetes Mellitus: A Case-Control Study.

التفاصيل البيبلوغرافية
العنوان: Vitamin B 12 Deficiency and Foot Ulcers in Type 2 Diabetes Mellitus: A Case-Control Study.
المؤلفون: Badedi M; Jazan Diabetes & Endocrine Center, Ministry of Health, Jazan, Saudi Arabia., Darraj H; Jazan Diabetes & Endocrine Center, Ministry of Health, Jazan, Saudi Arabia., Hummadi A; Jazan Diabetes & Endocrine Center, Ministry of Health, Jazan, Saudi Arabia., Solan Y; Jazan Diabetes & Endocrine Center, Ministry of Health, Jazan, Saudi Arabia., Zakri I; Jazan Diabetes & Endocrine Center, Ministry of Health, Jazan, Saudi Arabia., Khawaji A; Jazan Diabetes & Endocrine Center, Ministry of Health, Jazan, Saudi Arabia., Daghreeri M; Jazan Diabetes & Endocrine Center, Ministry of Health, Jazan, Saudi Arabia., Budaydi A; Abu Arish General Hospital, Ministry of Health, Hanoi, Saudi Arabia.
المصدر: Diabetes, metabolic syndrome and obesity : targets and therapy [Diabetes Metab Syndr Obes] 2019 Dec 06; Vol. 12, pp. 2589-2596. Date of Electronic Publication: 2019 Dec 06 (Print Publication: 2019).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Dove Medical Press Country of Publication: New Zealand NLM ID: 101515585 Publication Model: eCollection Cited Medium: Print ISSN: 1178-7007 (Print) Linking ISSN: 11787007 NLM ISO Abbreviation: Diabetes Metab Syndr Obes Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Auckland, N.Z.] : Dove Medical Press, c2008-
مستخلص: Objective: To assess the association between vitamin B 12 deficiency and the development of diabetic foot ulcers (DFU) in type 2 diabetes mellitus (T2DM).
Methods: This is a case-control study that enrolled 323 Saudi adults with T2DM randomly selected from the Jazan Diabetes & Endocrine Center, Saudi Arabia from January 1, 2019, to July 31, 2019. The sample included 108 newly diagnosed cases with DFU and 215 control participants with T2DM unaffected by and free of foot ulcers (1:2 ratio). Logistic regression analysis was performed to determine the DFU predictors and to examine the association of DFU and vitamin B 12 deficiency.
Results: The highest DFU rates were found among the male participants and the participants older than 45 years. Neuropathy, vasculopathy, vitamin B 12 deficiency, poor glycemic control, poor feet self-care, Charcot foot, physical inactivity, and spending long time standing at work were significantly associated with DFU, and all except physical inactivity and spending long time standing at work were independent predictors of DFU. After adjustment for the covariates, vitamin B 12 deficiency was significantly associated with DFU (odds ratio 3.1), indicating that the patients with T2DM and vitamin B 12 deficiency had a three times higher risk of developing DFU than those with normal vitamin B 12 levels.
Conclusion: Vitamin B 12 deficiency had a significant association with DFU among the Saudi participants with T2DM. Establishing the causality and clarifying the biological role of vitamin B12 deficiency in DFU is important aims for future studies.
Competing Interests: The authors report no conflict of interest in this work.
(© 2019 Badedi et al.)
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فهرسة مساهمة: Keywords: Jazan; Saudi Arabia; foot ulcer; type 2 diabetes mellitus; vitamin B12 deficiency
تواريخ الأحداث: Date Created: 20191213 Latest Revision: 20240723
رمز التحديث: 20240723
مُعرف محوري في PubMed: PMC6902870
DOI: 10.2147/DMSO.S233683
PMID: 31827332
قاعدة البيانات: MEDLINE
الوصف
تدمد:1178-7007
DOI:10.2147/DMSO.S233683