دورية أكاديمية
Health-related quality of life of thyroid cancer patients undergoing radioiodine therapy: a cohort real-world study in a reference public cancer hospital in Brazil.
| العنوان: | Health-related quality of life of thyroid cancer patients undergoing radioiodine therapy: a cohort real-world study in a reference public cancer hospital in Brazil. |
|---|---|
| المؤلفون: | Ramim JE; National Cancer Institute (INCA), Praça Cruz Vermelha, 23, Centro, Rio de Janeiro - RJ, Brazil., Cardoso MAS; National Cancer Institute (INCA), Praça Cruz Vermelha, 23, Centro, Rio de Janeiro - RJ, Brazil., de Oliveira GLC; National Cancer Institute (INCA), Praça Cruz Vermelha, 23, Centro, Rio de Janeiro - RJ, Brazil., Gomes ML; National Cancer Institute (INCA), Praça Cruz Vermelha, 23, Centro, Rio de Janeiro - RJ, Brazil., Guimarães TT; National Cancer Institute (INCA), Praça Cruz Vermelha, 23, Centro, Rio de Janeiro - RJ, Brazil., de Mello RCR; National Cancer Institute (INCA), Praça Cruz Vermelha, 23, Centro, Rio de Janeiro - RJ, Brazil., Bergmann A; National Cancer Institute (INCA), Praça Cruz Vermelha, 23, Centro, Rio de Janeiro - RJ, Brazil., Pujatti PB; National Cancer Institute (INCA), Praça Cruz Vermelha, 23, Centro, Rio de Janeiro - RJ, Brazil. pujatti.pb@gmail.com. |
| المصدر: | Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2020 Aug; Vol. 28 (8), pp. 3771-3779. Date of Electronic Publication: 2019 Dec 12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer International Country of Publication: Germany NLM ID: 9302957 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1433-7339 (Electronic) Linking ISSN: 09414355 NLM ISO Abbreviation: Support Care Cancer Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin : Springer International, c1993- |
| مواضيع طبية MeSH: | Iodine Radioisotopes/*therapeutic use , Quality of Life/*psychology , Thyroid Neoplasms/*radiotherapy, Adult ; Aged ; Brazil ; Cancer Care Facilities ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Surveys and Questionnaires ; Thyroid Neoplasms/mortality |
| مستخلص: | Purpose: The purpose of this study was to access changes in health-related quality of life (HRQoL) caused by radioiodine therapy (RAI) in thyroid cancer patients. Methods: Prospective cohort study at Brazilian National Cancer Institute with patients enrolled between March 2015 and June 2017. RAI was performed by administration of 1.11 to 9.25 GBq of Na 131 I. EORTC QLQ-C30 v3 and EORTC QLQ-H&N35 questionnaires were applied to determine HRQoL at baseline, 1 week and 3 months after RAI. HRQoL during follow-up was evaluated by calculation of score absolute changes in each domain. Descriptive analysis was performed by measures of central tendency and dispersion. Changes in HRQoL were evaluated by paired t-test. The association between social demographic and clinical data and HRQoL was assessed by univariate linear regression for significantly changed domains, and p < 0.05 was considered significant. Results: An improvement on global HRQoL and social Function post-therapy (p = 0.002 and p < 0.001) and on role (p = 0.038), emotional (p < 0.001), and cognitive function (p = 0.016) during RAI were observed. Nausea and vomiting (p < 0,001), pain (p < 0.001), sensitivity problems (p < 0.001), problems with social contact (p < 0.001), dry mouth (p = 0.007), and sticky saliva (p = 0.001) increased during RAI. Females were more sensible to changes in nausea and vomiting, and patients < 55 years experienced higher changes in sense during RAI. Conclusions: Although RAI might affect HRQoL negatively, patients experienced an improvement on global HRQoL and symptoms reduction post-therapy. |
| فهرسة مساهمة: | Keywords: Differentiated thyroid cancer; Health-related quality of life; Iodine-131; Radioiodine therapy; Thyroid carcinoma |
| المشرفين على المادة: | 0 (Iodine Radioisotopes) |
| تواريخ الأحداث: | Date Created: 20191214 Date Completed: 20200806 Latest Revision: 20200806 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1007/s00520-019-05225-x |
| PMID: | 31832820 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1433-7339 |
|---|---|
| DOI: | 10.1007/s00520-019-05225-x |