دورية أكاديمية
Conformal Coating of Stem Cell-Derived Islets for β Cell Replacement in Type 1 Diabetes.
العنوان: | Conformal Coating of Stem Cell-Derived Islets for β Cell Replacement in Type 1 Diabetes. |
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المؤلفون: | Stock AA; Diabetes Research Institute, University of Miami Miller School of Medicine, 1450 NW 10(th) Avenue, Miami, FL 33136, USA; Department of Biomedical Engineering, University of Miami, Miami, FL 33146, USA., Manzoli V; Diabetes Research Institute, University of Miami Miller School of Medicine, 1450 NW 10(th) Avenue, Miami, FL 33136, USA., De Toni T; Diabetes Research Institute, University of Miami Miller School of Medicine, 1450 NW 10(th) Avenue, Miami, FL 33136, USA; Department of Biomedical Engineering, University of Miami, Miami, FL 33146, USA., Abreu MM; Diabetes Research Institute, University of Miami Miller School of Medicine, 1450 NW 10(th) Avenue, Miami, FL 33136, USA., Poh YC; Semma Therapeutics, Inc., Cambridge, MA 02142, USA., Ye L; Semma Therapeutics, Inc., Cambridge, MA 02142, USA., Roose A; Semma Therapeutics, Inc., Cambridge, MA 02142, USA., Pagliuca FW; Semma Therapeutics, Inc., Cambridge, MA 02142, USA., Thanos C; Semma Therapeutics, Inc., Cambridge, MA 02142, USA., Ricordi C; Diabetes Research Institute, University of Miami Miller School of Medicine, 1450 NW 10(th) Avenue, Miami, FL 33136, USA; Department of Biomedical Engineering, University of Miami, Miami, FL 33146, USA; Department of Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA., Tomei AA; Diabetes Research Institute, University of Miami Miller School of Medicine, 1450 NW 10(th) Avenue, Miami, FL 33136, USA; Department of Biomedical Engineering, University of Miami, Miami, FL 33146, USA; Department of Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA. Electronic address: atomei@miami.edu. |
المصدر: | Stem cell reports [Stem Cell Reports] 2020 Jan 14; Vol. 14 (1), pp. 91-104. Date of Electronic Publication: 2019 Dec 12. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101611300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-6711 (Electronic) Linking ISSN: 22136711 NLM ISO Abbreviation: Stem Cell Reports Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [Cambridge, MA] : Cell Press, c 2013- |
مواضيع طبية MeSH: | Cell Differentiation* , Islets of Langerhans Transplantation*, Diabetes Mellitus, Type 1/*therapy , Insulin-Secreting Cells/*cytology , Stem Cells/*cytology, Animals ; Cells, Cultured ; Cryopreservation/methods ; Disease Models, Animal ; Female ; Humans ; Insulin-Secreting Cells/metabolism ; Male ; Mice ; Stem Cells/metabolism ; Transplantation, Heterologous |
مستخلص: | The scarcity of donors and need for immunosuppression limit pancreatic islet transplantation to a few patients with labile type 1 diabetes. Transplantation of encapsulated stem cell-derived islets (SC islets) might extend the applicability of islet transplantation to a larger cohort of patients. Transplantation of conformal-coated islets into a confined well-vascularized site allows long-term diabetes reversal in fully MHC-mismatched diabetic mice without immunosuppression. Here, we demonstrated that human SC islets reaggregated from cryopreserved cells display glucose-stimulated insulin secretion in vitro. Importantly, we showed that conformally coated SC islets displayed comparable in vitro function with unencapsulated SC islets, with conformal coating permitting physiological insulin secretion. Transplantation of SC islets into the gonadal fat pad of diabetic NOD-scid mice revealed that both unencapsulated and conformal-coated SC islets could reverse diabetes and maintain human-level euglycemia for more than 80 days. Overall, these results provide support for further evaluation of safety and efficacy of conformal-coated SC islets in larger species. (Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.) |
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معلومات مُعتمدة: | R01 DK109929 United States DK NIDDK NIH HHS; R56 DK109929 United States DK NIDDK NIH HHS |
فهرسة مساهمة: | Keywords: Type 1 Diabetes; alginate; conformal coating; encapsulation; insulin; islet transplantation; polyethylene glycol; stem cell-derived islets; thiol-ene click chemistry; β cells |
تواريخ الأحداث: | Date Created: 20191217 Date Completed: 20200922 Latest Revision: 20240725 |
رمز التحديث: | 20240726 |
مُعرف محوري في PubMed: | PMC6962554 |
DOI: | 10.1016/j.stemcr.2019.11.004 |
PMID: | 31839542 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2213-6711 |
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DOI: | 10.1016/j.stemcr.2019.11.004 |