دورية أكاديمية
أعرض في EDS

Conformal Coating of Stem Cell-Derived Islets for β Cell Replacement in Type 1 Diabetes.

التفاصيل البيبلوغرافية
العنوان: Conformal Coating of Stem Cell-Derived Islets for β Cell Replacement in Type 1 Diabetes.
المؤلفون: Stock AA; Diabetes Research Institute, University of Miami Miller School of Medicine, 1450 NW 10(th) Avenue, Miami, FL 33136, USA; Department of Biomedical Engineering, University of Miami, Miami, FL 33146, USA., Manzoli V; Diabetes Research Institute, University of Miami Miller School of Medicine, 1450 NW 10(th) Avenue, Miami, FL 33136, USA., De Toni T; Diabetes Research Institute, University of Miami Miller School of Medicine, 1450 NW 10(th) Avenue, Miami, FL 33136, USA; Department of Biomedical Engineering, University of Miami, Miami, FL 33146, USA., Abreu MM; Diabetes Research Institute, University of Miami Miller School of Medicine, 1450 NW 10(th) Avenue, Miami, FL 33136, USA., Poh YC; Semma Therapeutics, Inc., Cambridge, MA 02142, USA., Ye L; Semma Therapeutics, Inc., Cambridge, MA 02142, USA., Roose A; Semma Therapeutics, Inc., Cambridge, MA 02142, USA., Pagliuca FW; Semma Therapeutics, Inc., Cambridge, MA 02142, USA., Thanos C; Semma Therapeutics, Inc., Cambridge, MA 02142, USA., Ricordi C; Diabetes Research Institute, University of Miami Miller School of Medicine, 1450 NW 10(th) Avenue, Miami, FL 33136, USA; Department of Biomedical Engineering, University of Miami, Miami, FL 33146, USA; Department of Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA., Tomei AA; Diabetes Research Institute, University of Miami Miller School of Medicine, 1450 NW 10(th) Avenue, Miami, FL 33136, USA; Department of Biomedical Engineering, University of Miami, Miami, FL 33146, USA; Department of Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA. Electronic address: atomei@miami.edu.
المصدر: Stem cell reports [Stem Cell Reports] 2020 Jan 14; Vol. 14 (1), pp. 91-104. Date of Electronic Publication: 2019 Dec 12.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101611300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-6711 (Electronic) Linking ISSN: 22136711 NLM ISO Abbreviation: Stem Cell Reports Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, c 2013-
مواضيع طبية MeSH: Cell Differentiation* , Islets of Langerhans Transplantation*, Diabetes Mellitus, Type 1/*therapy , Insulin-Secreting Cells/*cytology , Stem Cells/*cytology, Animals ; Cells, Cultured ; Cryopreservation/methods ; Disease Models, Animal ; Female ; Humans ; Insulin-Secreting Cells/metabolism ; Male ; Mice ; Stem Cells/metabolism ; Transplantation, Heterologous
مستخلص: The scarcity of donors and need for immunosuppression limit pancreatic islet transplantation to a few patients with labile type 1 diabetes. Transplantation of encapsulated stem cell-derived islets (SC islets) might extend the applicability of islet transplantation to a larger cohort of patients. Transplantation of conformal-coated islets into a confined well-vascularized site allows long-term diabetes reversal in fully MHC-mismatched diabetic mice without immunosuppression. Here, we demonstrated that human SC islets reaggregated from cryopreserved cells display glucose-stimulated insulin secretion in vitro. Importantly, we showed that conformally coated SC islets displayed comparable in vitro function with unencapsulated SC islets, with conformal coating permitting physiological insulin secretion. Transplantation of SC islets into the gonadal fat pad of diabetic NOD-scid mice revealed that both unencapsulated and conformal-coated SC islets could reverse diabetes and maintain human-level euglycemia for more than 80 days. Overall, these results provide support for further evaluation of safety and efficacy of conformal-coated SC islets in larger species.
(Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.)
References: Diabetes. 1993 Jan;42(1):12-21. (PMID: 8420809)
Diabetes. 2013 Dec;62(12):4004-5. (PMID: 24264402)
World J Transplant. 2016 Mar 24;6(1):69-90. (PMID: 27011906)
Diabetologia. 2018 Mar;61(3):509-516. (PMID: 29275427)
Nat Commun. 2016 May 10;7:11463. (PMID: 27163171)
Diabetes. 2016 May;65(5):1350-61. (PMID: 26916086)
Transplantation. 1996 Apr 27;61(8):1272-4. (PMID: 8610431)
Trends Biotechnol. 2018 Apr;36(4):445-456. (PMID: 29455936)
Nat Biotechnol. 2006 Nov;24(11):1392-401. (PMID: 17053790)
Transplantation. 2017 May;101(5):1025-1035. (PMID: 27525644)
Biochim Biophys Acta. 1984 May 22;804(1):133-6. (PMID: 6426526)
Diabetes. 2017 May;66(5):1111-1120. (PMID: 28507211)
Rev Diabet Stud. 2017 Spring;14(1):51-78. (PMID: 28632821)
Lancet. 2014 Jan 4;383(9911):69-82. (PMID: 23890997)
Transplantation. 2016 Feb;100 Suppl 2:S1-44. (PMID: 26840096)
Cell Metab. 2018 Mar 6;27(3):549-558.e4. (PMID: 29514065)
Diabetes. 2017 Jul;66(7):1748-1754. (PMID: 28637827)
Nat Med. 2016 Mar;22(3):306-11. (PMID: 26808346)
ACS Nano. 2015 Jul 28;9(7):6872-81. (PMID: 26125494)
Diabetes Care. 2016 Jul;39(7):1230-40. (PMID: 27208344)
Xenotransplantation. 2018 Nov;25(6):e12450. (PMID: 30117193)
Cell. 2014 Oct 9;159(2):428-39. (PMID: 25303535)
Adv Drug Deliv Rev. 2014 Apr;67-68:84-92. (PMID: 24184490)
Xenotransplantation. 2017 Jul;24(4):. (PMID: 28513004)
Endocrinology. 2008 Sep;149(9):4322-8. (PMID: 18511515)
Macromol Mater Eng. 2019 Apr;304(4):. (PMID: 31929732)
Expert Opin Biol Ther. 2015;15(9):1321-36. (PMID: 26156291)
Nat Biotechnol. 2008 Apr;26(4):443-52. (PMID: 18288110)
Transplantation. 2017 Nov;101(11):2705-2712. (PMID: 28263224)
Diabetes. 2005 Mar;54(3):687-93. (PMID: 15734844)
Ann Biomed Eng. 2014 Feb;42(2):312-22. (PMID: 23881112)
Prog Polym Sci. 2012 Jan;37(1):106-126. (PMID: 22125349)
PLoS One. 2015 Aug 10;10(8):e0134428. (PMID: 26258815)
Curr Diab Rep. 2017 Mar;17(3):14. (PMID: 28271465)
Methods Mol Biol. 2017;1479:335-345. (PMID: 27738947)
ACS Biomater Sci Eng. 2016 Feb 8;2(2):165-179. (PMID: 28361125)
Curr Transplant Rep. 2016 Sep;3(3):254-263. (PMID: 28451515)
Panminerva Med. 2016 Mar;58(1):72-7. (PMID: 26837777)
Biotechnol Bioeng. 2018 Jan;115(1):232-245. (PMID: 28865118)
BMJ. 2017 Apr 3;357:j1321. (PMID: 28373161)
Nat Rev Endocrinol. 2017 May;13(5):268-277. (PMID: 27834384)
Methods Mol Biol. 2017;1479:305-333. (PMID: 27738946)
Biofabrication. 2017 May 18;9(2):025019. (PMID: 28516893)
Transplantation. 2010 Aug 15;90(3):238-43. (PMID: 20463635)
Pediatr Diabetes. 2018 May;19(3):346-353. (PMID: 29094512)
Adv Drug Deliv Rev. 2014 Apr;67-68:35-73. (PMID: 23916992)
Nature. 2019 May;569(7756):368-373. (PMID: 31068696)
Diabetes Metab Res Rev. 2010 May;26(4):280-6. (PMID: 20503260)
Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10514-9. (PMID: 24982192)
J Biomed Mater Res A. 2007 Dec 15;83(4):1128-1137. (PMID: 17595019)
Am J Transplant. 2018 Mar;18(3):590-603. (PMID: 29068143)
Xenotransplantation. 2017 Jan;24(1):. (PMID: 28247506)
Am J Transplant. 2015 Mar;15(3):618-27. (PMID: 25693473)
معلومات مُعتمدة: R01 DK109929 United States DK NIDDK NIH HHS; R56 DK109929 United States DK NIDDK NIH HHS
فهرسة مساهمة: Keywords: Type 1 Diabetes; alginate; conformal coating; encapsulation; insulin; islet transplantation; polyethylene glycol; stem cell-derived islets; thiol-ene click chemistry; β cells
تواريخ الأحداث: Date Created: 20191217 Date Completed: 20200922 Latest Revision: 20240725
رمز التحديث: 20240726
مُعرف محوري في PubMed: PMC6962554
DOI: 10.1016/j.stemcr.2019.11.004
PMID: 31839542
قاعدة البيانات: MEDLINE
الوصف
تدمد:2213-6711
DOI:10.1016/j.stemcr.2019.11.004