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Effect of Interleukin-15 Receptor Alpha Ablation on the Metabolic Responses to Moderate Exercise Simulated by in vivo Isometric Muscle Contractions.

التفاصيل البيبلوغرافية
العنوان: Effect of Interleukin-15 Receptor Alpha Ablation on the Metabolic Responses to Moderate Exercise Simulated by in vivo Isometric Muscle Contractions.
المؤلفون: Loro E; Department of Physiology, Pennsylvania Muscle Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States., Jang C; Department of Chemistry, Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, United States., Quinn WJ 3rd; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States., Baur JA; Department of Physiology, Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States., Arany ZP; Department of Medicine, Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States., Khurana TS; Department of Physiology, Pennsylvania Muscle Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
المصدر: Frontiers in physiology [Front Physiol] 2019 Nov 26; Vol. 10, pp. 1439. Date of Electronic Publication: 2019 Nov 26 (Print Publication: 2019).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101549006 Publication Model: eCollection Cited Medium: Print ISSN: 1664-042X (Print) Linking ISSN: 1664042X NLM ISO Abbreviation: Front Physiol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Research Foundation
مستخلص: Lack of interleukin 15 receptor alpha (IL15RA) increases spontaneous activity, exercise capacity and protects from diet-induced obesity by enhancing muscle energy metabolism, suggesting a role as exercise mimetic for IL15RA antagonists. Using controlled in vivo muscle stimulation mimicking moderate exercise in normal and Il15ra -/- mice, we mapped and contrasted the metabolic pathways activated upon stimulation or deletion of IL15RA. Stimulation caused the differential regulation of 123 out of the 321 detected metabolites (FDR ≤ 0.05 and fold change ≥ ±1.5). The main energy pathways activated were fatty acid oxidation, nucleotide metabolism, and anaplerotic reactions. Notably, resting Il15ra -/- muscles were primed in a semi-exercised state, characterized by higher pool sizes of fatty acids oxidized to support muscle activity. These studies identify the role of IL15RA in the system-wide metabolic response to exercise and should enable translational studies to harness the potential of IL15RA blockade as a novel exercise mimetic strategy.
(Copyright © 2019 Loro, Jang, Quinn, Baur, Arany and Khurana.)
References: Exerc Sport Sci Rev. 1991;19:507-37. (PMID: 1936094)
Semin Neurol. 2014 Nov;34(5):542-56. (PMID: 25520026)
J Physiol. 2017 May 1;595(9):2839-2847. (PMID: 27696420)
J Neurosci. 2002 Jul 15;22(14):5808-12. (PMID: 12122041)
Am J Physiol Endocrinol Metab. 2009 Jan;296(1):E191-202. (PMID: 19001550)
Pflugers Arch. 2006 Feb;451(5):606-16. (PMID: 16155759)
J Appl Physiol (1985). 2014 Nov 15;117(10):1110-9. (PMID: 25190738)
Cell. 2006 Dec 15;127(6):1109-22. (PMID: 17112576)
Exerc Sport Sci Rev. 2013 Apr;41(2):100-6. (PMID: 23072822)
Cell Metab. 2017 Jan 10;25(1):118-127. (PMID: 27818261)
Arthritis Rheum. 2010 Nov;62(11):3300-10. (PMID: 20617528)
Mitochondrion. 2015 Nov;25:87-97. (PMID: 26458787)
Mol Cell Biochem. 1999 Sep;199(1-2):111-7. (PMID: 10544959)
Cell Metab. 2017 Feb 7;25(2):242-247. (PMID: 27889389)
J Physiol. 2001 Oct 1;536(Pt 1):295-304. (PMID: 11579177)
Endocrinology. 2013 Jan;154(1):232-45. (PMID: 23161867)
Cell Metab. 2019 Jul 2;30(1):92-110.e4. (PMID: 31006592)
Nat Med. 2017 Feb;23(2):223-234. (PMID: 27991918)
J Clin Invest. 2013 Mar;123(3):1229-40. (PMID: 23376793)
J Clin Invest. 1980 Dec;66(6):1419-23. (PMID: 7440723)
Am J Physiol Regul Integr Comp Physiol. 2015 Oct 15;309(8):R835-44. (PMID: 26269523)
Metab Brain Dis. 2017 Apr;32(2):297-302. (PMID: 27837366)
Immunity. 1998 Nov;9(5):669-76. (PMID: 9846488)
J Physiol. 2017 Aug 1;595(15):5209-5226. (PMID: 28542873)
J Mol Neurosci. 2010 Jun;41(2):315-21. (PMID: 20012227)
Cell. 2008 Aug 8;134(3):405-15. (PMID: 18674809)
J Physiol. 1997 Aug 1;502 ( Pt 3):703-13. (PMID: 9279819)
Gene Ther. 2015 Apr;22(4):341-7. (PMID: 25503694)
Cell Metab. 2019 Jul 2;30(1):78-91.e4. (PMID: 31006590)
Bioinformatics. 2016 Sep 15;32(18):2847-9. (PMID: 27207943)
Int J Biochem Cell Biol. 2005 Aug;37(8):1567-71. (PMID: 15896666)
Cell. 2018 Sep 6;174(6):1571-1585.e11. (PMID: 30193114)
J Physiol. 2009 Jul 15;587(Pt 14):3691-701. (PMID: 19470781)
J Biol Chem. 1996 Feb 23;271(8):4209-14. (PMID: 8626764)
Am J Clin Nutr. 2000 Aug;72(2 Suppl):558S-63S. (PMID: 10919960)
Cardiovasc Res. 2013 Apr 1;98(1):47-55. (PMID: 23341578)
Nucleic Acids Res. 2018 Jul 2;46(W1):W486-W494. (PMID: 29762782)
J Cell Sci. 2018 Nov 2;131(21):. (PMID: 30301784)
Bone. 2017 Oct;103:20-30. (PMID: 28602725)
Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11299-11308. (PMID: 31110021)
Nat Genet. 1999 Apr;21(4):353-4. (PMID: 10192379)
Am J Physiol. 1999 Jan;276(1):C120-7. (PMID: 9886927)
PLoS One. 2016 Sep 29;11(9):e0162995. (PMID: 27684068)
Int J Sports Med. 2000 Jan;21(1):1-12. (PMID: 10683091)
Cytokine. 2013 Jan;61(1):41-5. (PMID: 23116661)
Brain Behav Immun. 2010 Nov;24(8):1340-6. (PMID: 20600810)
Blood. 2012 Jul 5;120(1):e1-8. (PMID: 22496150)
Acta Physiol Scand. 1989 Jun;136(2):193-8. (PMID: 2782092)
Curr Sports Med Rep. 2010 Jul-Aug;9(4):227-32. (PMID: 20622541)
J Clin Invest. 2011 Aug;121(8):3120-32. (PMID: 21765213)
Cell Metab. 2015 Nov 3;22(5):922-35. (PMID: 26437602)
Am J Physiol Endocrinol Metab. 2015 Jun 15;308(12):E1131-9. (PMID: 25921578)
Diabetes. 2008 Jan;57(1):41-9. (PMID: 17934141)
Am J Physiol. 1993 Sep;265(3 Pt 1):E380-91. (PMID: 8214047)
فهرسة مساهمة: Keywords: exercise; exercise mimetics; fatty acid oxidation; in vivo stimulation; interleukin-15 receptor alpha; metabolism; metabolomics; muscle
تواريخ الأحداث: Date Created: 20191219 Latest Revision: 20201001
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC6901992
DOI: 10.3389/fphys.2019.01439
PMID: 31849697
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-042X
DOI:10.3389/fphys.2019.01439