دورية أكاديمية

Mechanisms of Oral Bacterial Virulence Factors in Pancreatic Cancer.

التفاصيل البيبلوغرافية
العنوان: Mechanisms of Oral Bacterial Virulence Factors in Pancreatic Cancer.
المؤلفون: Sun Z; Department of Biomedical Science, Universiti Putra Malaysia, Serdang, Malaysia., Xiong C; Department of Public Health Microbiology, School of Public Health, Fudan University, Shanghai, China., Teh SW; Department of Medical Microbiology and Parasitology, Universiti Putra Malaysia, Serdang, Malaysia., Lim JCW; Pharmacotherapeutics Unit, Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia., Kumar S; Department of Medical Microbiology and Parasitology, Universiti Putra Malaysia, Serdang, Malaysia.; Genetics and Regenerative Medicine Research Centre, Universiti Putra Malaysia, Serdang, Malaysia.; UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Malaysia., Thilakavathy K; Department of Biomedical Science, Universiti Putra Malaysia, Serdang, Malaysia.; Genetics and Regenerative Medicine Research Centre, Universiti Putra Malaysia, Serdang, Malaysia.
المصدر: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2019 Dec 04; Vol. 9, pp. 412. Date of Electronic Publication: 2019 Dec 04 (Print Publication: 2019).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review
اللغة: English
بيانات الدورية: Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101585359 Publication Model: eCollection Cited Medium: Internet ISSN: 2235-2988 (Electronic) Linking ISSN: 22352988 NLM ISO Abbreviation: Front Cell Infect Microbiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Media SA
مواضيع طبية MeSH: Bacterial Physiological Phenomena* , Host-Pathogen Interactions* , Virulence Factors*/genetics, Mouth/*microbiology , Pancreatic Neoplasms/*etiology, Bacterial Infections/complications ; Bacterial Infections/metabolism ; Bacterial Infections/microbiology ; Digestive System/microbiology ; Humans
مستخلص: Pancreatic cancer is a highly lethal disease, and most patients remain asymptomatic until the disease enters advanced stages. There is lack of knowledge in the pathogenesis, effective prevention and early diagnosis of pancreatic cancer. Recently, bacteria were found in pancreatic tissue that has been considered sterile before. The distribution of flora in pancreatic cancer tissue was reported to be different from normal pancreatic tissue. These abnormally distributed bacteria may be the risk factors for inducing pancreatic cancer. Therefore, studies on combined effect of multi-bacterial and multi-virulence factors may add to the knowledge of pancreatic cancer pathogenesis and aid in designing new preventive and therapeutic strategies. In this review, we outlined three oral bacteria associated with pancreatic cancer and their virulence factors linked with cancer.
(Copyright © 2019 Sun, Xiong, Teh, Lim, Kumar and Thilakavathy.)
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فهرسة مساهمة: Keywords: CDT; FadA; Gingipains; NDK; oral bacteria; pancreatic cancer; virulence factors
المشرفين على المادة: 0 (Virulence Factors)
تواريخ الأحداث: Date Created: 20191224 Date Completed: 20200811 Latest Revision: 20200811
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6904357
DOI: 10.3389/fcimb.2019.00412
PMID: 31867287
قاعدة البيانات: MEDLINE