دورية أكاديمية
cDC1 IL-27p28 Production Predicts Vaccine-Elicited CD8 + T Cell Memory and Protective Immunity.
| العنوان: | cDC1 IL-27p28 Production Predicts Vaccine-Elicited CD8 + T Cell Memory and Protective Immunity. |
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| المؤلفون: | Kilgore AM; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045; and., Pennock ND; Oregon Health and Science University, Portland, OR 97239., Kedl RM; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045; and ross.kedl@cuanschutz.edu. |
| المصدر: | Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2020 Feb 01; Vol. 204 (3), pp. 510-517. Date of Electronic Publication: 2019 Dec 23. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association of Immunologists Country of Publication: United States NLM ID: 2985117R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1550-6606 (Electronic) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Bethesda, MD : American Association of Immunologists Original Publication: Baltimore : Williams & Wilkins, c1950- |
| مواضيع طبية MeSH: | CD8-Positive T-Lymphocytes/*immunology , Dendritic Cells/*immunology , Interleukins/*metabolism , Listeria monocytogenes/*physiology , Listeriosis/*immunology , Vaccines/*immunology, Animals ; Cells, Cultured ; Cytokines/metabolism ; Disease Models, Animal ; Humans ; Immunity ; Immunologic Memory ; Interleukins/genetics ; Lymphocyte Activation ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Th1 Cells/immunology ; Up-Regulation ; Vaccination |
| مستخلص: | Although adjuvants and formulations are often either empirically derived, or at best judged by their ability to elicit broad inflammation, it would be ideal if specific innate correlates of adaptive immunity could be identified to set a universally applicable benchmark for adjuvant evaluation. Using an IL-27 reporter transgenic mouse model, we show in this study that conventional type 1 dendritic cell IL-27 production in the draining lymph node 12 h after s.c. vaccination directly correlates with downstream CD8 + T cell memory and protective immunity against infectious challenge. This correlation is robust, reproducible, predictive, entirely unique to vaccine biology, and is the only innate correlate of CD8 + T cell immune memory yet to be identified. Our results provide new insights into the basic biology of adjuvant-elicited cellular immunity and have clear implications for the screening and evaluation of novel adjuvants. (Copyright © 2020 by The American Association of Immunologists, Inc.) |
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| معلومات مُعتمدة: | R01 AI066121 United States AI NIAID NIH HHS; R01 AI117918 United States AI NIAID NIH HHS; R01 AI126899 United States AI NIAID NIH HHS |
| المشرفين على المادة: | 0 (Cytokines) 0 (Il27 protein, mouse) 0 (Interleukins) 0 (Vaccines) |
| تواريخ الأحداث: | Date Created: 20191225 Date Completed: 20200810 Latest Revision: 20210201 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC6981069 |
| DOI: | 10.4049/jimmunol.1901357 |
| PMID: | 31871021 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1550-6606 |
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| DOI: | 10.4049/jimmunol.1901357 |