دورية أكاديمية
Red wine consumption mitigates the cognitive impairments in low-density lipoprotein receptor knockout (LDLr -/- ) mice.
| العنوان: | Red wine consumption mitigates the cognitive impairments in low-density lipoprotein receptor knockout (LDLr -/- ) mice. |
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| المؤلفون: | De Paula GC; Department of Biochemistry, Federal University of Santa Catarina, Florianópolis, Brazil., de Oliveira J; Laboratory of Experimental Neurology, Extremo Sul Catarinense University, Criciúma, Brazil., Engel DF; Department of Biochemistry, Federal University of Santa Catarina, Florianópolis, Brazil., Lopes SC; Department of Pharmacology, Federal University of Santa Catarina, Florianópolis, Brazil., Moreira ELG; Department of Physiological Science, Federal University of Santa Catarina, Florianópolis, Brazil., Figueiredo CP; School of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Prediger RD; Department of Pharmacology, Federal University of Santa Catarina, Florianópolis, Brazil., Fabro de Bem A; Department of Biochemistry, Federal University of Santa Catarina, Florianópolis, Brazil.; Department of Physiological Science, University of Brasilia, Brasilia, Brazil. |
| المصدر: | Nutritional neuroscience [Nutr Neurosci] 2021 Dec; Vol. 24 (12), pp. 978-988. Date of Electronic Publication: 2020 Jan 07. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 100892202 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-8305 (Electronic) Linking ISSN: 1028415X NLM ISO Abbreviation: Nutr Neurosci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2016- : Abingdon : Taylor & Francis Original Publication: [Amsterdam?] : Harwood Academic Publishers : Overseas Publishers Association [distributor], c1998- |
| مواضيع طبية MeSH: | Wine*, Cognitive Dysfunction/*etiology , Cognitive Dysfunction/*prevention & control , Hypercholesterolemia/*complications , Receptors, LDL/*physiology, Animals ; Behavior, Animal ; Brain/blood supply ; Cholesterol, Dietary/administration & dosage ; Disease Models, Animal ; Hippocampus/physiopathology ; Hypercholesterolemia/genetics ; Hypercholesterolemia/physiopathology ; Liver Diseases, Alcoholic ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Motor Activity ; Receptors, LDL/deficiency ; Receptors, LDL/genetics |
| مستخلص: | Although the benefits of moderate intake of red wine in decreasing incidence of cardiovascular diseases associated to hypercholesterolemia are well recognized, there are still widespread misconceptions about its effects on the hypercholesterolemia-related cognitive impairments. Herein we investigated the putative benefits of regular red wine consumption on cognitive performance of low-density lipoprotein receptor knockout (LDLr -/- ) mice, an animal model of familial hypercholesterolemia, which display cognitive impairments since early ages. The red wine was diluted into the drinking water to a final concentration of 6% ethanol and was available for 60 days for LDLr -/- mice fed a normal or high-cholesterol diet. The results indicated that moderate red wine consumption did not alter locomotor parameters and liver toxicity. Across multiple cognitive tasks evaluating spatial learning/reference memory and recognition/identification memory, hypercholesterolemic mice drinking red wine performed significantly better than water group, regardless of diet. Additionally, immunofluorescence assays indicated a reduction of astrocyte activation and lectin stain in the hippocampus of LDLr -/- mice under consumption of red wine. These findings demonstrate that the moderate consumption of red wine attenuates short- and long-term memory decline associated with hypercholesterolemia in mice and suggest that it could be through a neurovascular action. |
| فهرسة مساهمة: | Keywords: Hypercholesterolemia; LDLr−/− mice; blood-brain barrier; cognitive impairments; memory; neurovascular unit; red wine |
| المشرفين على المادة: | 0 (Cholesterol, Dietary) 0 (Receptors, LDL) |
| تواريخ الأحداث: | Date Created: 20200109 Date Completed: 20220225 Latest Revision: 20220225 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1080/1028415X.2019.1704472 |
| PMID: | 31910791 |
| قاعدة البيانات: | MEDLINE |
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