دورية أكاديمية
أعرض في EDS

Targeted donor complement blockade after brain death prevents delayed graft function in a nonhuman primate model of kidney transplantation.

التفاصيل البيبلوغرافية
العنوان: Targeted donor complement blockade after brain death prevents delayed graft function in a nonhuman primate model of kidney transplantation.
المؤلفون: Danobeitia JS; Department of Surgery, Division of Transplantation, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin, USA., Zens TJ; Department of Surgery, Division of Transplantation, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin, USA., Chlebeck PJ; Department of Surgery, Division of Transplantation, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin, USA., Zitur LJ; Department of Surgery, Division of Transplantation, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin, USA., Reyes JA; Department of Surgery, Division of Transplantation, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin, USA., Eerhart MJ; Department of Surgery, Division of Transplantation, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin, USA., Coonen J; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA., Capuano S; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA., D'Alessandro AM; Department of Surgery, Division of Transplantation, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin, USA., Torrealba JR; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Burguete D; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Brunner K; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA., Van Amersfoort E; Pharming Technologies B.V., Leiden, the Netherlands., Ponstein Y; Pharming Technologies B.V., Leiden, the Netherlands., Van Kooten C; Department of Nephrology, Leiden University Medical Center, Leiden, the Netherlands., Jankowska-Gan E; Department of Surgery, Division of Transplantation, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin, USA., Burlingham W; Department of Surgery, Division of Transplantation, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin, USA., Sullivan J; Department of Surgery, Division of Transplantation, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin, USA., Djamali A; Department of Medicine, Division of Nephrology, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin, USA., Pozniak M; Department of Radiology, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin, USA., Yankol Y; Department of Surgery, Division of Transplantation, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin, USA., Fernandez LA; Department of Surgery, Division of Transplantation, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin, USA.
المصدر: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2020 Jun; Vol. 20 (6), pp. 1513-1526. Date of Electronic Publication: 2020 Feb 20.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 100968638 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-6143 (Electronic) Linking ISSN: 16006135 NLM ISO Abbreviation: Am J Transplant Subsets: MEDLINE
أسماء مطبوعة: Publication: 2023- : [New York] : Elsevier
Original Publication: Copenhagen : Munksgaard International Publishers, 2001-
مواضيع طبية MeSH: Kidney Transplantation*/adverse effects, Animals ; Brain Death ; Delayed Graft Function/etiology ; Delayed Graft Function/prevention & control ; Graft Survival ; Humans ; Primates ; Risk Factors ; Tissue Donors
مستخلص: Delayed graft function (DGF) in renal transplant is associated with reduced graft survival and increased immunogenicity. The complement-driven inflammatory response after brain death (BD) and posttransplant reperfusion injury play significant roles in the pathogenesis of DGF. In a nonhuman primate model, we tested complement-blockade in BD donors to prevent DGF and improve graft survival. BD donors were maintained for 20 hours; kidneys were procured and stored at 4°C for 43-48 hours prior to implantation into ABO-compatible, nonsensitized, MHC-mismatched recipients. Animals were divided into 3 donor-treatment groups: G1 - vehicle, G2 - rhC1INH+heparin, and G3 - heparin. G2 donors showed significant reduction in classical complement pathway activation and decreased levels of tumor necrosis factor α and monocyte chemoattractant protein 1. DGF was diagnosed in 4/6 (67%) G1 recipients, 3/3 (100%) G3 recipients, and 0/6 (0%) G2 recipients (P = .008). In addition, G2 recipients showed superior renal function, reduced sC5b-9, and reduced urinary neutrophil gelatinase-associated lipocalin in the first week posttransplant. We observed no differences in incidence or severity of graft rejection between groups. Collectively, the data indicate that donor-management targeting complement activation prevents the development of DGF. Our results suggest a pivotal role for complement activation in BD-induced renal injury and postulate complement blockade as a promising strategy for the prevention of DGF after transplantation.
(© 2020 The American Society of Transplantation and the American Society of Transplant Surgeons.)
التعليقات: Comment in: Am J Transplant. 2020 Jun;20(6):1473-1474. (PMID: 32147904)
References: PLoS One. 2016 Oct 26;11(10):e0165493. (PMID: 27783665)
Am J Transplant. 2018 Dec;18(12):2955-2964. (PMID: 29637714)
Am J Transplant. 2011 Apr;11(4):660-9. (PMID: 21446970)
Transplantation. 2018 Jan;102(1):79-87. (PMID: 28731906)
Mol Immunol. 2017 Apr;84:77-83. (PMID: 27989433)
Nephrol Dial Transplant. 2011 Jul;26(7):2345-54. (PMID: 21127132)
PLoS One. 2017 Aug 23;12(8):e0183701. (PMID: 28832655)
Am J Transplant. 2016 Jun;16(6):1834-47. (PMID: 26932731)
Transplantation. 2008 Oct 15;86(7):889-94. (PMID: 18852649)
Curr Opin Organ Transplant. 2010 Aug;15(4):486-91. (PMID: 20631616)
Kidney Int. 2010 Jul;78(2):152-9. (PMID: 20336054)
Nephrol Dial Transplant. 2009 Mar;24(3):1039-47. (PMID: 19103734)
Kidney Int. 2000 Aug;58(2):859-66. (PMID: 10916111)
Circ Res. 2009 Nov 20;105(11):1094-101. (PMID: 19815824)
Transplantation. 2019 Feb;103(2):420-427. (PMID: 30299374)
Transplantation. 1997 Apr 15;63(7):968-74. (PMID: 9112349)
Ann Surg. 2009 Jun;249(6):889-99. (PMID: 19474697)
Lancet. 2004 Nov 13-19;364(9447):1814-27. (PMID: 15541456)
Am J Physiol Gastrointest Liver Physiol. 2008 Nov;295(5):G1042-9. (PMID: 18787060)
Curr Opin Organ Transplant. 2011 Apr;16(2):151-6. (PMID: 21415817)
Biomed Res Int. 2014;2014:361065. (PMID: 24967359)
Am J Transplant. 2017 Nov;17(11):2810-2819. (PMID: 28444847)
Transplantation. 2008 Apr 15;85(7):923-7. (PMID: 18408568)
Drug News Perspect. 2004 Sep;17(7):439-46. (PMID: 15514703)
Transplantation. 2013 Mar 27;95(6):816-20. (PMID: 23348894)
Curr Opin Organ Transplant. 2009 Feb;14(1):10-5. (PMID: 19337140)
Clin Exp Immunol. 2016 Jun;184(3):378-88. (PMID: 26874675)
Transplantation. 2010 Apr 27;89(8):937-44. (PMID: 20134394)
J Immunol. 2007 Sep 15;179(6):3966-72. (PMID: 17785834)
J Immunol. 2003 Feb 1;170(3):1517-23. (PMID: 12538716)
Arch Biochem Biophys. 1999 Jan 15;361(2):215-22. (PMID: 9882449)
N Engl J Med. 2013 Nov 7;369(19):1797-806. (PMID: 24195547)
Transplantation. 2013 Nov 27;96(10):885-9. (PMID: 24056620)
Transpl Immunol. 2011 May;24(4):233-7. (PMID: 21440065)
J Clin Invest. 2000 May;105(10):1363-71. (PMID: 10811844)
J Burn Care Res. 2012 Jul-Aug;33(4):544-51. (PMID: 22447201)
Am J Transplant. 2010 Oct;10(10):2279-86. (PMID: 20883559)
Br J Pharmacol. 2003 Jun;139(4):845-53. (PMID: 12813008)
PLoS One. 2017 Sep 19;12(9):e0182552. (PMID: 28926566)
Crit Care Med. 2012 Mar;40(3):770-7. (PMID: 22080632)
J Surg Res. 2012 Aug;176(2):639-48. (PMID: 22440934)
J Immunol. 1998 Jan 1;160(1):475-84. (PMID: 9552006)
Am J Pathol. 2004 Nov;165(5):1677-88. (PMID: 15509537)
Immunogenetics. 2010 Dec;62(11-12):773-80. (PMID: 20882385)
J Nephrol. 2008 Mar-Apr;21(2):221-8. (PMID: 18446717)
J Transl Med. 2016 Sep 23;14(1):277. (PMID: 27663514)
Kidney Int. 2015 Oct;88(4):851-8. (PMID: 26108067)
Transplantation. 2011 Jul 27;92(2):163-9. (PMID: 21677599)
Am J Transplant. 2016 Dec;16(12):3468-3478. (PMID: 27184779)
Stroke. 2012 Sep;43(9):2457-67. (PMID: 22744646)
Am J Transplant. 2016 Jan;16(1):325-33. (PMID: 26280899)
Clin Transplant. 1997 Aug;11(4):259-64. (PMID: 9267712)
Am J Transplant. 2012 Apr;12(4):877-87. (PMID: 22225993)
Am J Transplant. 2011 Nov;11(11):2279-96. (PMID: 21929642)
J Surg Res. 2005 Jan;123(1):118-25. (PMID: 15652959)
Crit Care. 2011 Jan 26;15(1):203. (PMID: 21345278)
Am J Pathol. 2010 Apr;176(4):1648-59. (PMID: 20150432)
Circulation. 2013 Mar 26;127(12):1290-9. (PMID: 23443736)
Transplantation. 2015 Feb;99(2):299-308. (PMID: 25606785)
Yonsei Med J. 1997 Jun;38(3):133-41. (PMID: 9259612)
Clin Exp Immunol. 2008 Jul;153(1):117-26. (PMID: 18505432)
معلومات مُعتمدة: T32 AI125231 United States AI NIAID NIH HHS; R01 AI119140 United States AI NIAID NIH HHS; R01 AI110617 United States AI NIAID NIH HHS; T32 DK007665 United States DK NIDDK NIH HHS; P51 OD011106 United States OD NIH HHS
فهرسة مساهمة: Keywords: animal models: nonhuman primate; complement biology; delayed graft function (DGF); donors and donation: donation after brain death (DBD); immunosuppression/immune modulation; ischemia reperfusion injury (IRI); kidney transplantation/nephrology; translational research/science
تواريخ الأحداث: Date Created: 20200111 Date Completed: 20210621 Latest Revision: 20230124
رمز التحديث: 20230126
مُعرف محوري في PubMed: PMC7261643
DOI: 10.1111/ajt.15777
PMID: 31922336
قاعدة البيانات: MEDLINE
الوصف
تدمد:1600-6143
DOI:10.1111/ajt.15777