دورية أكاديمية
أعرض في EDS

Effect of metabolic syndrome on mean pulmonary arterial pressures in patients with acute pulmonary embolism treated with catheter-directed thrombolysis.

التفاصيل البيبلوغرافية
العنوان: Effect of metabolic syndrome on mean pulmonary arterial pressures in patients with acute pulmonary embolism treated with catheter-directed thrombolysis.
المؤلفون: Stewart LK; Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, United States of America., Beam DM; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States of America., Casciani T; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States of America., Cameron SJ; Department of Cardiology, University of Rochester Medical Center, Rochester, NY, United States of America., Kline JA; Department of Emergency Medicine, Department of Cellular and Integrative Physiology, Indiana University School of Medicine, 720 Eskenazi Ave, Indianapolis, IN 46202, United States of America. Electronic address: jefkline@iu.edu.
المصدر: International journal of cardiology [Int J Cardiol] 2020 Mar 01; Vol. 302, pp. 138-142. Date of Electronic Publication: 2019 Dec 26.
نوع المنشور: Journal Article; Multicenter Study
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8200291 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1874-1754 (Electronic) Linking ISSN: 01675273 NLM ISO Abbreviation: Int J Cardiol Subsets: MEDLINE
أسماء مطبوعة: Publication: Amsterdam : Elsevier
Original Publication: Amsterdam : Elsevier/North-Holland Biomedical Press, c1981-
مواضيع طبية MeSH: Registries*, Fibrinolytic Agents/*therapeutic use , Metabolic Syndrome/*physiopathology , Pulmonary Embolism/*drug therapy , Pulmonary Wedge Pressure/*physiology , Thrombolytic Therapy/*methods, Acute Disease ; Female ; Follow-Up Studies ; Humans ; Male ; Metabolic Syndrome/complications ; Middle Aged ; Prospective Studies ; Pulmonary Embolism/complications ; Treatment Outcome
مستخلص: Background: Metabolic syndrome (MetS) has been associated with a procoagulant and hypofibrinolytic state. Current data exploring the role of MetS in venous thromboembolism (VTE) are limited. The objective was to measure the prevalence of MetS in patients with acute PE receiving catheter-directed thrombolysis (CDT) and to investigate its effect on mean pulmonary arterial pressure and overall treatment success.
Methods: We used a 3-year prospective registry of ED patients with acute PE with severity qualifying for activation of a PE response team (PERT). All patients had CDT with catheter-measured mPAP and angiography. The presence or absence of MetS components were extracted from chart review based on the following criteria: 1. body mass index (BMI) >30 kg/m 2 ; 2. diagnosed hypertension; 3. diabetes mellitus (including HbA1c >6.5%) and; 4. dyslipidemia (including triglycerides >150 mg/dL or high-density lipoprotein <40 mg/dL).
Results: Of the 134 patients, 85% met the criteria for at least one of four MetS components, with obesity being most common, present in 71%. Results demonstrated a positive concordance between the number of criteria for MetS and MPAP, both pre- and post-fibrinolysis, as pressures tended to increase with each additional MetS criterion. Multivariate regression analysis determined age (-), BMI (+) and hypertension (+) to be significant independent predictor variables for mPAP.
Conclusions: MetS was common in patients with more severe manifestations of PE and was associated with higher mPAP values both at diagnosis and following treatment with CDT.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
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معلومات مُعتمدة: K12 HL133310 United States HL NHLBI NIH HHS; UM1 HL113203 United States HL NHLBI NIH HHS
فهرسة مساهمة: Keywords: catheter-directed thrombolysis; metabolic syndrome; obesity; pulmonary embolism
المشرفين على المادة: 0 (Fibrinolytic Agents)
تواريخ الأحداث: Date Created: 20200118 Date Completed: 20201223 Latest Revision: 20210302
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7022200
DOI: 10.1016/j.ijcard.2019.12.043
PMID: 31948673
قاعدة البيانات: MEDLINE
الوصف
تدمد:1874-1754
DOI:10.1016/j.ijcard.2019.12.043