دورية أكاديمية
Monitoring oral iron therapy in children with iron deficiency anemia: an observational, prospective, multicenter study of AIEOP patients (Associazione Italiana Emato-Oncologia Pediatrica).
| العنوان: | Monitoring oral iron therapy in children with iron deficiency anemia: an observational, prospective, multicenter study of AIEOP patients (Associazione Italiana Emato-Oncologia Pediatrica). |
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| المؤلفون: | Russo G; Clinical and Experimental Medicine, University of Catania, Catania, Italy. diberuss@unict.it.; Pediatric Hemato-Oncology Unit, Azienda Policlinico Vittorio Emanuele, Catania, Italy. diberuss@unict.it., Guardabasso V; Azienda Policlinico Vittorio Emanuele, Catania, Italy., Romano F; Department of Pediatric and Public Health Sciences, University of Torino, Torino, Italy., Corti P; Department of Pediatric Clinic, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy., Samperi P; Pediatric Hemato-Oncology Unit, Azienda Policlinico Vittorio Emanuele, Catania, Italy., Condorelli A; Clinical and Experimental Medicine, University of Catania, Catania, Italy., Sainati L; Pediatric Hemato-Oncology Unit, University of Padova, Padova, Italy., Maruzzi M; Pediatric Hemato-Oncology Unit, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy., Facchini E; Pediatric Hemato-Oncology Unit, Policlinico S.Orsola Malpighi, Bologna, Italy., Fasoli S; Pediatric Unit, Carlo Poma Hospital, Mantova, Italy., Giona F; Department of Cellular Biotechnologies and Hematology, 'Sapienza' University, Rome, Italy., Caselli D; Maria Paternò Arezzo Hospital, Ragusa, Italy., Pizzato C; Pediatric Unit, Hospital, Treviso, Italy., Marinoni M; Pediatric Department, University of Insubria, Ospedale 'F. Del Ponte' Varese, Italy., Boscarol G; Department of Pediatrics, Central Teaching Hospital, Bolzano, Italy., Bertoni E; Pediatric Onco-hematology Unit, Spedali Civili, Brescia, Italy., Casciana ML; Pediatric Unit, Carlo Poma Hospital, Mantova, Italy., Tucci F; Department of Pediatric Hematology Oncology, Anna Meyer Children's University Hospital, Florence, Italy., Capolsini I; Pediatric Onco-Hematology Unit, Perugia, Italy., Notarangelo LD; Pediatric Onco-hematology Unit, Spedali Civili, Brescia, Italy., Giordano P; Pediatric Unit 'F. Vecchio', Department of Biomedical Sciences and Human Oncology, University of Bari 'Aldo Moro', Bari, Italy., Ramenghi U; Department of Pediatric and Public Health Sciences, University of Torino, Torino, Italy., Colombatti R; Pediatric Hemato-Oncology Unit, University of Padova, Padova, Italy. |
| المصدر: | Annals of hematology [Ann Hematol] 2020 Mar; Vol. 99 (3), pp. 413-420. Date of Electronic Publication: 2020 Jan 21. |
| نوع المنشور: | Clinical Trial; Journal Article; Multicenter Study; Observational Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9107334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0584 (Electronic) Linking ISSN: 09395555 NLM ISO Abbreviation: Ann Hematol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Berlin : Springer Verlag Original Publication: Berlin ; New York : Springer International, c1991- |
| مواضيع طبية MeSH: | Anemia, Iron-Deficiency/*drug therapy , Ferrous Compounds/*administration & dosage, Administration, Oral ; Adolescent ; Anemia, Iron-Deficiency/blood ; Child ; Child, Preschool ; Female ; Ferrous Compounds/adverse effects ; Humans ; Infant ; Iron/administration & dosage ; Iron/adverse effects ; Male ; Prospective Studies |
| مستخلص: | Oral ferrous salts are standard treatment for children with iron deficiency anemia (IDA). The objective of our study was to monitor oral iron therapy in children, aged 3 months-12 years, with IDA. We prospectively collected clinical and hematological data of children with IDA, from 15 AIEOP (Associazione Italiana di Ematologia ed. Oncologia Pediatrica) centers. Response was measured by the increase of Hb from baseline. Of the 107 analyzed patients, 18 received ferrous gluconate/sulfate 2 mg/kg (ferrous 2), 7 ferrous gluconate/sulfate 4 mg/kg (ferrous 4), 7 ferric iron salts 2 mg/kg (ferric), 62 bis-glycinate iron 0.45 mg/kg (glycinate), and 13 liposomal iron 0.7-1.4 mg/kg (liposomal). Increase in reticulocytes was evident at 3 days, while Hb increase appeared at 2 weeks. Gain of Hb at 2 and 8 weeks revealed a higher median increase in both ferrous 2 and ferrous 4 groups. Gastro-intestinal side effects were reported in 16% (ferrous 2), 14% (ferrous 4), 6% (glycinate), and 0 (ferric and liposomal) patients. The reticulocyte counts significantly increased after 3 days from the start of oral iron supplementation. Bis-glycinate iron formulation had a good efficacy/safety profile and offers an acceptable alternative to ferrous iron preparations. |
| معلومات مُعتمدة: | 6C130203044 Università di Catania |
| فهرسة مساهمة: | Keywords: Bis glycinate iron; Children; Iron deficiency anemia; Liposomal iron; Reticulocyte |
| المشرفين على المادة: | 0 (Ferrous Compounds) 39R4TAN1VT (ferrous sulfate) E1UOL152H7 (Iron) U1B11I423Z (ferrous gluconate) |
| تواريخ الأحداث: | Date Created: 20200123 Date Completed: 20200317 Latest Revision: 20200317 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1007/s00277-020-03906-w |
| PMID: | 31965272 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1432-0584 |
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| DOI: | 10.1007/s00277-020-03906-w |