دورية أكاديمية
أعرض في EDS

Pattern and Significance of Tumour Budding in Colorectal Carcinomas Using ITBCC Guidelines: a Low Resource Setting Practice Observation.

التفاصيل البيبلوغرافية
العنوان: Pattern and Significance of Tumour Budding in Colorectal Carcinomas Using ITBCC Guidelines: a Low Resource Setting Practice Observation.
المؤلفون: Ezenkwa US; Department of Pathology, University College Hospital, Ibadan, Nigeria. uchennaezenkwa@gmail.com., Ogun GO; Department of Pathology, University College Hospital, Ibadan, Nigeria., Bamiro OO; Department of Pathology, University College Hospital, Ibadan, Nigeria., Mashor MI; Department of Pathology, University College Hospital, Ibadan, Nigeria., Okolo CA; Department of Pathology, University College Hospital, Ibadan, Nigeria., Adegoke OO; Department of Pathology, University College Hospital, Ibadan, Nigeria., Ogunbiyi OJ; Department of Pathology, University College Hospital, Ibadan, Nigeria.
المصدر: Journal of gastrointestinal cancer [J Gastrointest Cancer] 2020 Sep; Vol. 51 (3), pp. 1018-1023.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Science+Business Media Country of Publication: United States NLM ID: 101479627 Publication Model: Print Cited Medium: Internet ISSN: 1941-6636 (Electronic) NLM ISO Abbreviation: J Gastrointest Cancer Subsets: MEDLINE
أسماء مطبوعة: Publication: 2010- : New York : Springer Science+Business Media
Original Publication: New York, NY : Humana Press
مواضيع طبية MeSH: Adenocarcinoma, Mucinous/*pathology , Colorectal Neoplasms/*pathology , Practice Guidelines as Topic/*standards, Adenocarcinoma, Mucinous/economics ; Adenocarcinoma, Mucinous/surgery ; Colorectal Neoplasms/economics ; Colorectal Neoplasms/surgery ; Developing Countries ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Nigeria ; Retrospective Studies
مستخلص: Purpose: To determine the pattern and significance of tumour budding among colorectal carcinoma (CRC) Nigerian patients using the 2016 International Tumour Budding Consensus Conference (ITBCC) guidelines.
Methods: H&E-stained slides of resected CRC at the University College Hospital and a private laboratory, both in Ibadan, Nigeria, from January 2008 to December 2017 were reviewed. Patient age, gender, tumour size and location were obtained from the surgical pathology records. Tumours were graded and staged according to the 2010 WHO and the 2017 UICC protocols, respectively. Tumour budding was determined at × 20 objective lens magnification with a 20-mm eyepiece field number diameter. Descriptive, Mann-Whitney U and chi-square test statistics were applied using SPSS 20; p < 0.05 was considered significant.
Results: Ninety-six cases were included in this study. Fifty-one (53.1%) showed tumour budding. Tumour bud count was low (0-4) in 66 (68.8%), intermediate (5-9) in 12 (12.5%) and high (≥ 10) in 18 (18.8%) tumours. Four tumours had pT1 stage, 35 pT2, 37 pT3 and 20 pT4. Forty-three (44.8%) tumours were lymph node-positive, and 10 (10.4%) had metastasis. Patients' age and tumour size distribution were similar in the tumour budding and non-budding groups (52.4 ± 17.1/58.5 ± 13.9 years and 6.6 ± 2.9/6.6 ± 2.8 cm, respectively). There was significant association between tumour budding and tumour grade (p < 0.008), pT stage (p < 0.000), lymphovascular permeation (p < 0.000), perineural invasion (p < 0.003) and nodal status (p < 0.034), but not with gender (p = 0.588), metastasis (p = 0.327) and TNM group-stage (p = 0.062).
Conclusion: Tumour budding frequency is high among our CRC patients and is associated with poorer prognostic factors.
التعليقات: Erratum in: J Gastrointest Cancer. 2020 Feb 21;:. (PMID: 32086780)
فهرسة مساهمة: Keywords: Colorectal carcinoma; ITBCC; Tumour budding
تواريخ الأحداث: Date Created: 20200124 Date Completed: 20210326 Latest Revision: 20210326
رمز التحديث: 20240628
DOI: 10.1007/s12029-020-00365-4
PMID: 31970654
قاعدة البيانات: MEDLINE
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