دورية أكاديمية
Clear Cell Papillary Cystadenoma of the Ovary Masquerading as Metastatic Clear Cell Renal Cell Carcinoma: A Case Report and Review of the Literature.
العنوان: | Clear Cell Papillary Cystadenoma of the Ovary Masquerading as Metastatic Clear Cell Renal Cell Carcinoma: A Case Report and Review of the Literature. |
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المؤلفون: | Sharma AE, Hamedani FS, Barroeta JE, Pytel P, Bennett JA, Lastra RR |
المصدر: | International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists [Int J Gynecol Pathol] 2021 May 01; Vol. 40 (3), pp. 290-295. |
نوع المنشور: | Case Reports; Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 8214845 Publication Model: Print Cited Medium: Internet ISSN: 1538-7151 (Electronic) Linking ISSN: 02771691 NLM ISO Abbreviation: Int J Gynecol Pathol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: New York : Raven Press, c1982- |
مواضيع طبية MeSH: | Carcinoma, Renal Cell/*diagnostic imaging , Cystadenoma, Papillary/*diagnostic imaging , Ovarian Neoplasms/*diagnostic imaging, Carcinoma, Renal Cell/pathology ; Cystadenoma, Papillary/genetics ; Cystadenoma, Papillary/pathology ; Diagnosis, Differential ; Female ; High-Throughput Nucleotide Sequencing ; Humans ; Immunohistochemistry ; Microscopy, Electron ; Middle Aged ; Ovarian Neoplasms/pathology ; Ovary/diagnostic imaging ; Ovary/pathology ; Point Mutation ; Sequence Analysis, DNA ; Von Hippel-Lindau Tumor Suppressor Protein/genetics |
مستخلص: | Clear cell papillary cystadenoma of the epididymis is an uncommon benign neoplasm, usually seen in patients with von Hippel-Lindau disease. Morphologic and immunohistochemical examination aid in distinguishing clear cell papillary cystadenoma from malignant histologic mimics including low-grade mesothelial proliferations and metastatic clear cell renal cell carcinomas. Analogous lesions have been described in the female genital tract, often posing diagnostic challenges due to their low incidence. Here, we present the difficult diagnostic aspects of the first case of clear cell papillary cystadenoma involving the ovary, including the salient immunohistochemical, ultrastructural, and molecular characteristics. Competing Interests: The authors declare no conflict of interest. (Copyright © 2020 by the International Society of Gynecological Pathologists.) |
References: | Cox R, Vang R, Epstein JI. Papillary cystadenoma of the epididymis and broad ligament: morphologic and immunohistochemical overlap with clear cell papillary renal cell carcinoma. Am J Surg Pathol 2014;38:713–8. Gaffey MJ, Mills SE, Boyd JC. Aggressive papillary tumor of middle ear/temporal bone and adnexal papillary cystadenoma. Manifestations of von Hippel-Lindau disease. Am J Surg Pathol 1994;18:1254–60. Gersell DJ, King TC. Papillary cystadenoma of the mesosalpinx in von Hippel-Lindau disease. Am J Surg Pathol 1988;12:145–9. Nogales FF, Goyenaga P, Preda O, et al. An analysis of five clear cell papillary cystadenomas of mesosalpinx and broad ligament: four associated with von Hippel-Lindau disease and one aggressive sporadic type. Histopathology 2012;60:748–57. Seok JY, Kang M, An J, et al. Papillary cystadenoma of the fallopian tube not associated with von hippel-lindau disease: a case report. Korean J Pathol 2014;48:382–6. Shen T, Zhuang Z, Gersell DJ, et al. Allelic deletion of VHL gene detected in papillary tumors of the broad ligament, epididymis, and retroperitoneum in von Hippel-Lindau disease patients. Int J Surg Pathol 2000;8:207–12. Ordonez NG. Value of the MOC-31 monoclonal antibody in differentiating epithelial pleural mesothelioma from lung adenocarcinoma. Hum Pathol 1998;29:166–9. Chapel DB, Husain AN, Krausz T, et al. PAX8 expression in a subset of malignant peritoneal mesotheliomas and benign mesothelium has diagnostic implications in the differential diagnosis of ovarian serous carcinoma. Am J Surg Pathol 2017;41:1675–82. Laury AR, Hornick JL, Perets R, et al. PAX8 reliably distinguishes ovarian serous tumors from malignant mesothelioma. Am J Surg Pathol 2010;34:627–35. Xing D, Banet N, Sharma R, et al. Aberrant Pax-8 expression in well-differentiated papillary mesothelioma and malignant mesothelioma of the peritoneum: a clinicopathologic study. Hum Pathol 2018;72:160–6. Oczypok EA, Oury TD. Electron microscopy remains the gold standard for the diagnosis of epithelial malignant mesothelioma: a case study. Ultrastruct Pathol 2015;39:153–8. Dardick I, Jabi M, McCaughey WT, et al. Diffuse epithelial mesothelioma: a review of the ultrastructural spectrum. Ultrastruct Pathol 1987;11:503–33. Rohan SM, Xiao Y, Liang Y, et al. Clear-cell papillary renal cell carcinoma: molecular and immunohistochemical analysis with emphasis on the von Hippel-Lindau gene and hypoxia-inducible factor pathway-related proteins. Mod Pathol 2011;24:1207–20. Wolfe A, Dobin SM, Grossmann P, et al. Clonal trisomies 7,10 and 12, normal 3p and absence of VHL gene mutation in a clear cell tubulopapillary carcinoma of the kidney. Virchows Arch 2011;459:457–63. Smith-Hannah A, Naous R. Primary peritoneal epithelioid mesothelioma of clear cell type with a novel VHL gene mutation: a case report. Hum Pathol 2019;83:199–203. |
المشرفين على المادة: | EC 2.3.2.27 (Von Hippel-Lindau Tumor Suppressor Protein) EC 6.3.2.- (VHL protein, human) |
SCR Disease Name: | Clear-cell metastatic renal cell carcinoma |
تواريخ الأحداث: | Date Created: 20200128 Date Completed: 20211108 Latest Revision: 20211108 |
رمز التحديث: | 20231215 |
DOI: | 10.1097/PGP.0000000000000666 |
PMID: | 31985579 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1538-7151 |
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DOI: | 10.1097/PGP.0000000000000666 |