دورية أكاديمية
Impact of Rutin and Vitamin C combination on oxidative stress and glycemic control in patients with type 2 diabetes.
| العنوان: | Impact of Rutin and Vitamin C combination on oxidative stress and glycemic control in patients with type 2 diabetes. |
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| المؤلفون: | Ragheb SR; Clinical Pharmacy Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. Electronic address: dr.sararamzy@yahoo.com., El Wakeel LM; Clinical Pharmacy Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. Electronic address: lamywak@yahoo.com., Nasr MS; Internal Medicine Department, Division of Endocrinology, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Electronic address: merhan_nasr@hotmail.com., Sabri NA; Clinical Pharmacy Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. Electronic address: nagwa.sabri@yahoo.com. |
| المصدر: | Clinical nutrition ESPEN [Clin Nutr ESPEN] 2020 Feb; Vol. 35, pp. 128-135. Date of Electronic Publication: 2019 Nov 14. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101654592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2405-4577 (Electronic) Linking ISSN: 24054577 NLM ISO Abbreviation: Clin Nutr ESPEN Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Oxford] : Elsevier Ltd., [2015]- |
| مواضيع طبية MeSH: | Glycemic Control*, Ascorbic Acid/*therapeutic use , Diabetes Mellitus, Type 2/*drug therapy , Oxidative Stress/*drug effects , Rutin/*therapeutic use, Adult ; Blood Glucose ; Diabetes Mellitus, Type 2/blood ; Drug Therapy, Combination ; Fasting ; Female ; Glycated Hemoglobin ; Humans ; Hypoglycemic Agents/therapeutic use ; Insulin/therapeutic use ; Insulin Resistance ; Lipids/blood ; Male ; Malondialdehyde/blood ; Prospective Studies ; Quality of Life |
| مستخلص: | Aim: This study aimed to investigate the effect of Vitamin C alone and in combination with Rutin on the glycemic control, insulin resistance, lipid profile and oxidative stress markers in patients with type 2 diabetes. Methods: A prospective, randomized, controlled study conducted on 53 type 2 diabetes patients randomized into 3 groups; (group A) 20 received Rutin with vitamin C, (group B) 20receivedvitamin C and (group C)13 received antidiabetic treatment only. Fasting Blood Glucose (FBG), Hemoglobin A1c (HbA1c), fasting insulin, Malondialdehyde, Superoxide dismutase, Lipid profile and patients' quality of life (QOL) using SF-36 questionnaire were assessed in all patients at baseline and after 8 weeks. Results: At baseline, the 3 groups were comparable while FBG was lower in group C versus group A and B (p = 0.0021). After 8 weeks, a significant reduction was observed in % change of FBG in groups A and B versus group C (p = 0.0165, 0.0388 respectively). Low Density Lipoprotien-cholesterol (LDL-c) and Total cholesterol (TC) levels significantly improved in group B versus baseline (p = 0.0239,0.0166 respectively). QOL, physical functioning and energy domains improved significantly in group A versus group C (p = 0.0049, 0.0253 respectively), while role limitation to physical health and to emotional problem improved significantly in group B versus group C (p = 0.0267,0.0280 respectively). Conclusion: Vitamin C supplementation alone or with Rutin significantly reduced the % change of FBG compared to controls but had no effect on HbA1c, FBG,TC, fasting insulin and HOMA-IR or oxidative stress in T2DMpatients. Clinical Trial Registration Number: NCT03437902. Competing Interests: Declaration of Competing Interest None. (Copyright © 2019. Published by Elsevier Ltd.) |
| فهرسة مساهمة: | Keywords: Glycemic control; Oxidative stress; Rutin; Type 2 diabetes mellitus(T2DM); Vitamin C |
| سلسلة جزيئية: | ClinicalTrials.gov NCT03437902 |
| المشرفين على المادة: | 0 (Blood Glucose) 0 (Glycated Hemoglobin A) 0 (Hypoglycemic Agents) 0 (Insulin) 0 (Lipids) 0 (hemoglobin A1c protein, human) 4Y8F71G49Q (Malondialdehyde) 5G06TVY3R7 (Rutin) PQ6CK8PD0R (Ascorbic Acid) |
| تواريخ الأحداث: | Date Created: 20200129 Date Completed: 20210712 Latest Revision: 20221207 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.clnesp.2019.10.015 |
| PMID: | 31987106 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 2405-4577 |
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| DOI: | 10.1016/j.clnesp.2019.10.015 |