دورية أكاديمية
Cytokine Levels in Neural Pain in Leprosy.
| العنوان: | Cytokine Levels in Neural Pain in Leprosy. |
|---|---|
| المؤلفون: | Angst DBM; Leprosy Laboratory, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil.; Postgraduate Program in Neurology of Federal University of Rio de Janeiro State (UNIRIO), Rio de Janeiro, Brazil., Pinheiro RO; Leprosy Laboratory, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil., Vieira JSDS; Leprosy Laboratory, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil., Cobas RA; Endocrinology Discipline of the Faculty of Medical Sciences, State University of Rio de Janeiro (UERJ), Rio de Janeiro, Brazil., Hacker MAV; Leprosy Laboratory, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil., Pitta IJR; Leprosy Laboratory, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil.; Postgraduate Program in Neurology of Federal University of Rio de Janeiro State (UNIRIO), Rio de Janeiro, Brazil., Giesel LM; Leprosy Laboratory, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil., Sarno EN; Leprosy Laboratory, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil., Jardim MR; Leprosy Laboratory, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil.; Postgraduate Program in Neurology of Federal University of Rio de Janeiro State (UNIRIO), Rio de Janeiro, Brazil.; Neurology Discipline of the Faculty of Medical Sciences, State University of Rio de Janeiro (UERJ), Rio de Janeiro, Brazil. |
| المصدر: | Frontiers in immunology [Front Immunol] 2020 Jan 24; Vol. 11, pp. 23. Date of Electronic Publication: 2020 Jan 24 (Print Publication: 2020). |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
| مواضيع طبية MeSH: | Diabetic Neuropathies/*blood , Interleukin-1beta/*blood , Interleukin-6/*blood , Leprosy/*blood , Neuralgia/*blood , Neuritis/*blood, Aged ; Biomarkers/blood ; Brazil/epidemiology ; Cross-Sectional Studies ; Diabetic Neuropathies/diagnosis ; Diabetic Neuropathies/epidemiology ; Diagnosis, Differential ; Female ; Humans ; Leprosy/diagnosis ; Leprosy/epidemiology ; Male ; Middle Aged ; Neuralgia/diagnosis ; Neuralgia/epidemiology ; Neuritis/diagnosis ; Neuritis/epidemiology ; Retrospective Studies |
| مستخلص: | Pain is a frequent symptom in leprosy patients. It may be predominantly nociceptive, as in neuritis, or neuropathic, due to injury or nerve dysfunction. The differential diagnosis of these two forms of pain is a challenge in clinical practice, especially because it is quite common for a patient to suffer from both types of pain. A better understanding of cytokine profile may serve as a tool in assessing patients and also help to comprehend pathophysiology of leprosy pain. Patients with leprosy and neural pain ( n = 22), neuropathic pain ( n = 18), neuritis (nociceptive pain) ( n = 4), or no pain ( n = 17), further to those with diabetic neuropathy and neuropathic pain ( n = 17) were recruited at Souza Araujo Out-Patient Unit (Fiocruz, Rio de Janeiro, RJ, Brazil). Serum levels of IL1β, IL-6, IL-10, IL-17, TNF, CCL-2/MCP-1, IFN-γ, CXCL-10/IP-10, and TGF-β were evaluated in the different Groups. Impairment in thermal or pain sensitivity was the most frequent clinical finding (95.5%) in leprosy neuropathy patients with and without pain, but less frequent in Diabetic Group (88.2%). Previous reactional episodes have occurred in patients in the leprosy and Pain Group ( p = 0.027) more often. Analysis of cytokine levels have demonstrated that the concentrations of IL-1β, TNF, TGF-β, and IL-17 in serum samples of patients having leprosy neuropathy in combination with neuropathic or nociceptive pain were higher when compared to the samples of leprosy neuropathy patients without pain. In addition, these cytokine levels were significantly augmented in leprosy patients with neuropathic pain in relation to those with neuropathic pain due to diabetes. IL-1β levels are an independent variable associated with both types of pain in patients with leprosy neuropathy. IL-6 concentration was increased in both groups with pain. Moreover, CCL-2/MCP-1 and CXCL-10/IP-10 levels were higher in patients with diabetic neuropathy over those with leprosy neuropathy. In brief, IL-1β is an independent variable related to neuropathic and nociceptive pain in patients with leprosy, and could be an important biomarker for patient follow-up. IL-6 was higher in both groups with pain (leprosy and diabetic patients), and could be a therapeutic target in pain control. (Copyright © 2020 Angst, Pinheiro, Vieira, Cobas, Hacker, Pitta, Giesel, Sarno and Jardim.) |
| التعليقات: | Comment in: Front Immunol. 2023 Dec 05;14:1272471. (PMID: 38116016) |
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| فهرسة مساهمة: | Keywords: cytokines; diabetes; leprosy; neuropathic pain; neuropathy; nociceptive pain |
| المشرفين على المادة: | 0 (Biomarkers) 0 (IL1B protein, human) 0 (IL6 protein, human) 0 (Interleukin-1beta) 0 (Interleukin-6) |
| تواريخ الأحداث: | Date Created: 20200211 Date Completed: 20210223 Latest Revision: 20240325 |
| رمز التحديث: | 20240325 |
| مُعرف محوري في PubMed: | PMC6992577 |
| DOI: | 10.3389/fimmu.2020.00023 |
| PMID: | 32038662 |
| قاعدة البيانات: | MEDLINE |
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