دورية أكاديمية
The Eurasian lactase persistence variant LCT -13910 C/T is associated with vitamin D levels in individuals living at high latitude, more so than exposure to sunlight.
| العنوان: | The Eurasian lactase persistence variant LCT -13910 C/T is associated with vitamin D levels in individuals living at high latitude, more so than exposure to sunlight. |
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| المؤلفون: | Moghaddam A; Fürst Medisinsk Laboratorium, Søren Bulls vei 25, 1051 Oslo, Norway. |
| المصدر: | Journal of nutritional science [J Nutr Sci] 2020 Jan 13; Vol. 9, pp. e1. Date of Electronic Publication: 2020 Jan 13. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cambridge University Press Country of Publication: England NLM ID: 101590587 Publication Model: Electronic Cited Medium: Internet ISSN: 2048-6790 (Electronic) Linking ISSN: 20486790 NLM ISO Abbreviation: J Nutr Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge : Cambridge University Press, 2012- |
| مواضيع طبية MeSH: | Sunlight*, Lactase/*metabolism , Vitamin D/*blood, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Animals ; Calcium ; Child ; Female ; Humans ; Lactase/genetics ; Lactose Intolerance ; Male ; Micronutrients/blood ; Middle Aged ; Milk ; Regression Analysis ; Vitamin B 12/blood ; Vitamin D/analogs & derivatives ; Young Adult |
| مستخلص: | Rapid selection of a genetic variant that confers continuous life-long lactase production in Europeans ( LCT -13910 C/T) has been attributed to the advantages of acquiring nutrients from consuming milk without the disadvantages of lactose malabsorption. Individuals with this genetic lactase persistence (LP) variant generally consume more milk and have been shown to have higher levels of serum vitamin D. Vitamin D is the principal regulator of Ca absorption and its synthesis in skin is dependent on UVB exposure. The primary aim of the present study was to compare serum vitamin D concentrations with LP variant and to control for UVB exposure. Data from over 100 000 individuals living in Norway, a country with low UVB exposure, was retrospectively retrieved for comparison of genetic LP variant, serum 25-hydroxyvitamin D (25(OH)D) concentration and the time of year when serum samples were taken. For comparison, a similar analysis was performed with a natural dairy micronutrient, namely vitamin B (© The Author(s) 2020.) |
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| فهرسة مساهمة: | Keywords: 25(OH)D, 25-hydroxyvitamin D; Calcium; LP, lactase persistence; Lactase persistence; UVB; Vitamin B12; Vitamin D; vitB12, vitamin B12 |
| المشرفين على المادة: | 0 (Micronutrients) 1406-16-2 (Vitamin D) A288AR3C9H (25-hydroxyvitamin D) EC 3.2.1.108 (Lactase) P6YC3EG204 (Vitamin B 12) SY7Q814VUP (Calcium) |
| تواريخ الأحداث: | Date Created: 20200212 Date Completed: 20210604 Latest Revision: 20210604 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC6984125 |
| DOI: | 10.1017/jns.2019.41 |
| PMID: | 32042409 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2048-6790 |
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| DOI: | 10.1017/jns.2019.41 |