دورية أكاديمية
Evaluation of IL-2, IL-10, IL-4 and ɤ-interferon levels in the oral fluids of patients with hepatitis C, B and HIV.
| العنوان: | Evaluation of IL-2, IL-10, IL-4 and ɤ-interferon levels in the oral fluids of patients with hepatitis C, B and HIV. |
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| المؤلفون: | Azatyan V; Department of Therapeutic Stomatology, Yerevan State Medical University (YSMU), Yerevan, Armenia. vahe.azatyan@gmail.com., Yessayan L; Department of Therapeutic Stomatology, Yerevan State Medical University (YSMU), Yerevan, Armenia. lazyes@yandex.ru., Shmavonyan M; Department of Infectious Diseases, Yerevan State Medical University (YSMU), Yerevan, Armenia. sh_melaniya@mail.ru., Melik-Andreasyan G; National Center of Disease Control and Prevention, The Ministry of Health of Republic of Armenia. melikandreasyan@mail.ru., Perikhanyan A; Medical Affairs Department, FMD Contract Research Organization, Yerevan, Armenia. anush.peri@gmail.com., Porkshenyan K; Nork Clinical Infectious Hospital CJSC, Yerevan, Armenia. tima129@mail.ru. |
| المصدر: | Journal of infection in developing countries [J Infect Dev Ctries] 2019 May 16; Vol. 13 (5.1), pp. 69S-74S. Date of Electronic Publication: 2019 May 16. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Open Learning on Enteric Pathogens Country of Publication: Italy NLM ID: 101305410 Publication Model: Electronic Cited Medium: Internet ISSN: 1972-2680 (Electronic) Linking ISSN: 19722680 NLM ISO Abbreviation: J Infect Dev Ctries Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Italy?] : Open Learning on Enteric Pathogens |
| مواضيع طبية MeSH: | HIV Infections/*pathology , Hepatitis B/*pathology , Hepatitis C/*pathology , Interferon-gamma/*analysis , Interleukins/*analysis , Periodontitis/*pathology , Saliva/*chemistry, Adult ; Aged ; Aged, 80 and over ; Armenia ; Case-Control Studies ; Female ; HIV Infections/complications ; Hepatitis B/complications ; Hepatitis C/complications ; Hospitals, University ; Humans ; Immunologic Factors/analysis ; Male ; Middle Aged ; Periodontitis/complications ; Young Adult |
| مستخلص: | Introduction: Oral fluid cytokine levels can vary considerably during the onset of Inflammatory Periodontitis (IP) especially in people with hepatitis C virus (HCV), hepatitis B virus (HBV) and human immunodeficiency virus (HIV). Aim of our study was to evaluate levels of oral cytokines during the onset of IP among HCV, HBV and HIV negative and positive individuals in order to evaluate local immunity state during these infections. Methodology: This was a case control study with 3 groups of virally infected individuals and control group. All had IP including control group. Results: 45 patients (51.7%) had HCV, 18 (20.7%) HBV and 24 (27.6%) HIV. For IL-2 we received significant difference for all groups compared with control -2.83; HBV-31.1 (p < 0.001), HCV-25.99 (p < 0.001) and HIV-24.57 (p < 0.001). For IL-10 significant difference was observed between control -0.94 and HCV-3.63 (p = 0.027), HBV-8.38 (15.51) groups (p < 0.001). IL-4 was significantly higher in control group 14.29 compared to HCV 0.2 (p < 0.001) and HIV 0.21 (p = 0.037) group. The adjusted analysis where we consider age as possible confounder revealed that only IL-2 significantly differs for all groups compared with control group: control vs HCV (p = 0.001); control vs HBV (p = 0.024); control vs HIV (p = 0.004). Conclusions: Evidence for significant differences when comparing oral fluid cytokines of individuals with HCV, HBV and HIV with non-viral individuals was more obvious for IL-2. IL-2 levels were significantly higher in all 3 groups vs non-viral group even when age is confounder. Competing Interests: No Conflict of Interest is declared (Copyright (c) 2019 Anush Perikhanyan, Vahe Azatyan, Vahe Azatyan, Lazar Yessayan, Melanya Shmavonyan, Gayane Melik-Andreasyan, Kristina Porkshenyan.) |
| فهرسة مساهمة: | Keywords: HBV; HCV; HIV; Oral fluid; cytokines |
| المشرفين على المادة: | 0 (Immunologic Factors) 0 (Interleukins) 82115-62-6 (Interferon-gamma) |
| تواريخ الأحداث: | Date Created: 20200213 Date Completed: 20200715 Latest Revision: 20200715 |
| رمز التحديث: | 20221213 |
| DOI: | 10.3855/jidc.10919 |
| PMID: | 32049669 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1972-2680 |
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| DOI: | 10.3855/jidc.10919 |