دورية أكاديمية
أعرض في EDS

Atrial inflammation in different atrial fibrillation subtypes and its relation with clinical risk factors.

التفاصيل البيبلوغرافية
العنوان: Atrial inflammation in different atrial fibrillation subtypes and its relation with clinical risk factors.
المؤلفون: Wu L; Department of Pathology, Amsterdam University Medical Centers, location VUmc and AMC, Room L2-114, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. l.wu1@amsterdamumc.nl.; Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands. l.wu1@amsterdamumc.nl., Emmens RW; Department of Pathology, Amsterdam University Medical Centers, location VUmc and AMC, Room L2-114, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.; Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands., van Wezenbeek J; Department of Pathology, Amsterdam University Medical Centers, location VUmc and AMC, Room L2-114, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.; Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands., Stooker W; Department of Cardiac Surgery, OLVG, Amsterdam, The Netherlands., Allaart CP; Department of Cardiology, Amsterdam UMC, location VU Medical Center, Amsterdam, The Netherlands., Vonk ABA; Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.; Department of Cardiac Surgery, Amsterdam UMC, location VU Medical Center, Amsterdam, The Netherlands., van Rossum AC; Department of Cardiology, Amsterdam UMC, location VU Medical Center, Amsterdam, The Netherlands., Niessen HWM; Department of Pathology, Amsterdam University Medical Centers, location VUmc and AMC, Room L2-114, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.; Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.; Department of Cardiac Surgery, Amsterdam UMC, location VU Medical Center, Amsterdam, The Netherlands., Krijnen PAJ; Department of Pathology, Amsterdam University Medical Centers, location VUmc and AMC, Room L2-114, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.; Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.
المصدر: Clinical research in cardiology : official journal of the German Cardiac Society [Clin Res Cardiol] 2020 Oct; Vol. 109 (10), pp. 1271-1281. Date of Electronic Publication: 2020 Feb 18.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Country of Publication: Germany NLM ID: 101264123 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1861-0692 (Electronic) Linking ISSN: 18610684 NLM ISO Abbreviation: Clin Res Cardiol Subsets: MEDLINE
أسماء مطبوعة: Publication: Aug. 2007- : Heidelberg, Germany : Springer Medizin
Original Publication: Darmstadt, Germany : Springer Medizin, [2006]-
مواضيع طبية MeSH: Atrial Fibrillation/*physiopathology , Heart Atria/*physiopathology , Inflammation/*physiopathology, Adult ; Age Factors ; Aged ; Aged, 80 and over ; Atrial Fibrillation/surgery ; Catheter Ablation ; Disease Progression ; Female ; Humans ; Male ; Middle Aged ; Risk Factors
مستخلص: Objective: Inflammation of the atria is an important factor in the pathogenesis of atrial fibrillation (AF). Whether the extent of atrial inflammation relates with clinical risk factors of AF, however, is largely unknown. This we have studied comparing patients with paroxysmal and long-standing persistent/permanent AF.
Methods: Left atrial tissue was obtained from 50 AF patients (paroxysmal = 20, long-standing persistent/permanent = 30) that underwent a left atrial ablation procedure either or not in combination with coronary artery bypass grafting and/or valve surgery. Herein, the numbers of CD45+ and CD3+ inflammatory cells were quantified and correlated with the AF risk factors age, gender, diabetes, and blood CRP levels.
Results: The numbers of CD45+ and CD3+ cells were significantly higher in the adipose tissue of the atria compared with the myocardium in all AF patients but did not differ between AF subtypes. The numbers of CD45+ and CD3+ cells did not relate significantly to gender or diabetes in any of the AF subtypes. However, the inflammatory infiltrates as well as CK-MB and CRP blood levels increased significantly with increasing age in long-standing persistent/permanent AF and a moderate positive correlation was found between the extent of atrial inflammation and the CRP blood levels in both AF subtypes.
Conclusion: The extent of left atrial inflammation in AF patients was not related to the AF risk factors, diabetes and gender, but was associated with increasing age in patients with long-standing persistent/permanent AF. This may be indicative for a role of inflammation in the progression to long-standing persistent/permanent AF with increasing age.
References: Clin Res Cardiol. 2020 Jul;109(7):791-801. (PMID: 31667622)
J Thorac Cardiovasc Surg. 2015 Mar;149(3):886-92. (PMID: 25534301)
Heart Rhythm. 2010 Apr;7(4):438-44. (PMID: 20153266)
Eur Heart J. 2016 Oct 7;37(38):2893-2962. (PMID: 27567408)
Clin Res Cardiol. 2019 Jun;108(6):651-659. (PMID: 30460479)
Clin Res Cardiol. 2020 Mar;109(3):315-323. (PMID: 31325043)
JAMA. 2001 May 9;285(18):2370-5. (PMID: 11343485)
Pharmacol Ther. 2015 Oct;154:13-20. (PMID: 26116810)
Clin Res Cardiol. 2019 Nov;108(11):1276-1286. (PMID: 30963233)
Clin Res Cardiol. 2020 Mar;109(3):331-338. (PMID: 31263996)
Heart Vessels. 2005 Mar;20(2):45-9. (PMID: 15772777)
Hum Pathol. 1987 Aug;18(8):796-800. (PMID: 2440794)
Am J Cardiol. 2011 Jul 1;108(1):56-62. (PMID: 21529739)
Circulation. 2001 Dec 11;104(24):2886-91. (PMID: 11739301)
Am J Pathol. 2015 Aug;185(8):2096-104. (PMID: 26216282)
Clin Res Cardiol. 2019 Dec;108(12):1354-1363. (PMID: 30953179)
Chest. 1998 May;113(5):1290-5. (PMID: 9596308)
Clin Res Cardiol. 2020 Apr;109(4):409-416. (PMID: 31522249)
Circulation. 2003 Nov 18;108(20):2460-6. (PMID: 14581396)
PLoS One. 2017 Feb 22;12(2):e0172691. (PMID: 28225836)
Am J Cardiol. 2014 May 1;113(9):1505-8. (PMID: 24656480)
Circulation. 2002 Feb 12;105(6):685-90. (PMID: 11839622)
Am J Cardiol. 2005 Mar 15;95(6):764-7. (PMID: 15757607)
J Clin Invest. 2013 Mar;123(3):958-65. (PMID: 23454758)
Circulation. 2017 Mar 7;135(10):e146-e603. (PMID: 28122885)
Nat Rev Cardiol. 2015 Apr;12(4):230-43. (PMID: 25622848)
Eur Heart J. 2017 Jan 1;38(1):53-61. (PMID: 26612579)
Circ J. 2015;79(3):495-502. (PMID: 25746525)
معلومات مُعتمدة: 201708260020 China Scholarship Council
فهرسة مساهمة: Keywords: Atrial fibrillation; Inflammation; Lymphocytes; Risk factors
تواريخ الأحداث: Date Created: 20200220 Date Completed: 20210723 Latest Revision: 20210723
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC7515944
DOI: 10.1007/s00392-020-01619-8
PMID: 32072262
قاعدة البيانات: MEDLINE
الوصف
تدمد:1861-0692
DOI:10.1007/s00392-020-01619-8