دورية أكاديمية
Structural Analysis of Glaucoma Brain and its Association With Ocular Parameters.
| العنوان: | Structural Analysis of Glaucoma Brain and its Association With Ocular Parameters. |
|---|---|
| المؤلفون: | Gracitelli CPB; Department of Ophthalmology and Visual Sciences, Paulista School of Medicine, São Paulo Hospital, Federal University of São Paulo., Duque-Chica GL; Institute of Psychology, University of São Paulo.; Department of Psychology, University of Medellin, Medellin, Colombia., Sanches LG; Brain Institute-Hospital Israelita Albert Einstein, São Paulo, Brazil., Moura AL; Department of Ophthalmology and Visual Sciences, Paulista School of Medicine, São Paulo Hospital, Federal University of São Paulo.; Institute of Psychology, University of São Paulo., Nagy BV; Institute of Psychology, University of São Paulo.; Department of Mechatronics, Optics and Engineering Informatics, Budapest University of Technology and Economics, Budapest, Hungary., Teixeira SH; Department of Ophthalmology and Visual Sciences, Paulista School of Medicine, São Paulo Hospital, Federal University of São Paulo., Amaro E Jr; Brain Institute-Hospital Israelita Albert Einstein, São Paulo, Brazil., Ventura DF; Department of Ophthalmology and Visual Sciences, Paulista School of Medicine, São Paulo Hospital, Federal University of São Paulo.; Institute of Psychology, University of São Paulo., Paranhos A Jr; Department of Ophthalmology and Visual Sciences, Paulista School of Medicine, São Paulo Hospital, Federal University of São Paulo.; Brain Institute-Hospital Israelita Albert Einstein, São Paulo, Brazil. |
| المصدر: | Journal of glaucoma [J Glaucoma] 2020 May; Vol. 29 (5), pp. 393-400. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 9300903 Publication Model: Print Cited Medium: Internet ISSN: 1536-481X (Electronic) Linking ISSN: 10570829 NLM ISO Abbreviation: J Glaucoma Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2015- > : Philadelphia, PA : Wolters Kluwer Health, Inc. Original Publication: New York, N.Y. : Raven Press, c1992- |
| مواضيع طبية MeSH: | Magnetic Resonance Imaging*, Brain Diseases/*diagnostic imaging , Glaucoma/*diagnostic imaging , Occipital Lobe/*diagnostic imaging, Adult ; Aged ; Brain Diseases/physiopathology ; Cross-Sectional Studies ; Female ; Glaucoma/physiopathology ; Humans ; Intraocular Pressure/physiology ; Male ; Middle Aged ; Nerve Fibers/pathology ; Occipital Lobe/physiopathology ; Prospective Studies ; Retinal Ganglion Cells/pathology ; Tomography, Optical Coherence/methods ; Visual Acuity/physiology ; Visual Field Tests ; Visual Fields/physiology |
| مستخلص: | Precis: Glaucoma patients presented a decreased occipital pole surface area in both hemispheres. Moreover, these parameters are independently correlated with functional and structural ocular parameters. Purpose: The purpose of this study was to evaluate structural brain abnormalities in glaucoma patients using 3-Tesla magnetic resonance imaging and assess their correlation with associated structural and functional ocular findings. Patients and Methods: This cross-sectional prospective study included 30 glaucoma patients and 18 healthy volunteers. All participants underwent standard automated perimetry, spectral-domain optical coherence tomography, and 3.0-Tesla magnetic resonance imaging. Results: There was a significant difference between the surface area of the occipital pole in the left hemisphere of glaucoma patients (mean: 1253.9±149.3 mm) and that of control subjects (mean: 1341.9±129.8 mm), P=0.043. There was also a significant difference between the surface area of the occipital pole in the right hemisphere of glaucoma patients (mean: 1910.5±309.4 mm) and that of control subjects (mean: 2089.1±164.2 mm), P=0.029. There was no significant difference between the lingual, calcarine, superior frontal, and inferior frontal gyri of glaucoma patients and those of the control subjects (P>0.05 for all comparisons). The surface area of the occipital pole in the left hemisphere was significantly correlated with perimetry mean deviation values, visual acuity, age, and retinal nerve fiber layer thickness (P=0.001, <0.001, 0.010, and 0.006, respectively). The surface area of the occipital pole in the right hemisphere was significantly correlated with perimetry mean deviation values, visual field indices, visual acuity, age, and retinal nerve fiber layer thickness (P<0.001, 0.007, <0.001, 0.046, and <0.001, respectively). Conclusion: Glaucoma patients presented a decreased occipital pole surface area in both hemispheres that independently correlated with functional and structural ocular parameters. |
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| تواريخ الأحداث: | Date Created: 20200222 Date Completed: 20200928 Latest Revision: 20210208 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1097/IJG.0000000000001470 |
| PMID: | 32079996 |
| قاعدة البيانات: | MEDLINE |
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