دورية أكاديمية
أعرض في EDS

Sulodexide improves pain-free walking distance in patients with lower extremity peripheral arterial disease: A systematic review and meta-analysis.

التفاصيل البيبلوغرافية
العنوان: Sulodexide improves pain-free walking distance in patients with lower extremity peripheral arterial disease: A systematic review and meta-analysis.
المؤلفون: Gaddi AV; EuroGenLab, Bologna, Italy., Capello F; Department of Paediatrics, AUSL della Romagna, Ospedale Morgagni-Pierantoni, Forlì, Italy., Gheorghe-Fronea OF; Discipline of Cardiology, Clinical Emergency Hospital Bucharest, University of Medicine and Pharmacy 'Carol Davila', Bucharest, Romania., Fadda S; Department of Cardiology, ATS Sardegna, Italy., Darabont RO; Discipline of Internal Medicine and Cardiology, University Emergency Hospital Bucharest, University of Medicine and Pharmacy 'Carol Davila', Bucharest, Romania.
المصدر: JRSM cardiovascular disease [JRSM Cardiovasc Dis] 2020 Feb 14; Vol. 9, pp. 2048004020907002. Date of Electronic Publication: 2020 Feb 14 (Print Publication: 2020).
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Sage Country of Publication: England NLM ID: 101598607 Publication Model: eCollection Cited Medium: Print ISSN: 2048-0040 (Print) Linking ISSN: 20480040 NLM ISO Abbreviation: JRSM Cardiovasc Dis Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: November 2012- : London : Sage
Original Publication: London : RSM Press
مستخلص: Peripheral arterial disease is associated with very high cardiovascular risk. The main symptom is intermittent claudication, which strongly affects the quality of life. Therefore, treatment goals in peripheral arterial disease consist of the reduction of cardiovascular events and the relief of symptoms. An increase in pain-free walking distance, evaluated based on the Initial Claudication Distance, was also a strong positive prognostic factor in patients with peripheral arterial disease. Our objective was to reassess whether sulodexide is effective in improving Initial Claudication Distance. For this, we searched the literature according to the PRISMA checklist for double blind clinical trials assessing the improvement in the Initial Claudication Distance after 90 days of standard therapeutic regimen with sulodexide in adult patients with peripheral arterial disease. We found and assessed for bias in 11 studies eligible for review and meta-analysis. Data extracted from those studies favoured the sulodexide group, showing an overall difference in Initial Claudication Distance of +68.9 (CI 95%; ± 11.9 m) at the end of treatment (p < 0.001). According to this review, sulodexide is effective in improving Initial Claudication Distance and consequently the quality of life in patients with peripheral arterial disease. Further studies are needed to assess the effects of this drug on disease progression in asymptomatic patients with peripheral arterial disease.
(© The Author(s) 2020.)
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فهرسة مساهمة: Keywords: Peripheral arterial disease; drug therapy; intermittent claudication; lower extremity arterial disease; meta-analysis; walking distance
تواريخ الأحداث: Date Created: 20200229 Latest Revision: 20200928
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7025427
DOI: 10.1177/2048004020907002
PMID: 32110390
قاعدة البيانات: MEDLINE
الوصف
تدمد:2048-0040
DOI:10.1177/2048004020907002