دورية أكاديمية
Sucrose consumption alters steroid and dopamine signalling in the female rat brain.
| العنوان: | Sucrose consumption alters steroid and dopamine signalling in the female rat brain. |
|---|---|
| المؤلفون: | Tobiansky DJ; Department of Psychology, The University of British Columbia, Vancouver, British Columbia, Canada.; Djavad Mowafaghian Centre for Brain Health, The University of British Columbia, Vancouver, British Columbia, Canada., Kachkovski GV; Department of Psychology, The University of British Columbia, Vancouver, British Columbia, Canada., Enos RT; Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina, USA., Schmidt KL; Department of Psychology, The University of British Columbia, Vancouver, British Columbia, Canada., Murphy EA; Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina, USA., Soma KK; Department of Psychology, The University of British Columbia, Vancouver, British Columbia, Canada.; Djavad Mowafaghian Centre for Brain Health, The University of British Columbia, Vancouver, British Columbia, Canada.; Department of Zoology, The University of British Columbia, Vancouver, British Columbia, Canada. |
| المصدر: | The Journal of endocrinology [J Endocrinol] 2020 May; Vol. 245 (2), pp. 231-246. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioScientifica Country of Publication: England NLM ID: 0375363 Publication Model: Print Cited Medium: Internet ISSN: 1479-6805 (Electronic) Linking ISSN: 00220795 NLM ISO Abbreviation: J Endocrinol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Bristol, UK : BioScientifica Original Publication: Bristol, UK : Society for Endocrinology |
| مواضيع طبية MeSH: | Brain/*metabolism , Corticosterone/*metabolism , Dietary Sucrose/*pharmacology , Dopamine/*metabolism , Signal Transduction/*drug effects, Animals ; Eating/physiology ; Female ; Models, Animal ; Pregnancy ; Rats |
| مستخلص: | Sucrose consumption is associated with type 2 diabetes, cardiovascular disease, and cognitive deficits. Sucrose intake during pregnancy might have particularly prominent effects on metabolic, endocrine, and neural physiology. It remains unclear how consumption of sucrose affects parous females, especially in brain circuits that mediate food consumption and reward processing. Here, we examine whether a human-relevant level of sucrose before, during, and after pregnancy (17-18 weeks total) influences metabolic and neuroendocrine physiology in female rats. Females were fed either a control diet or a macronutrient-matched, isocaloric sucrose diet (25% of kcal from sucrose). Metabolically, sucrose impairs glucose tolerance, increases liver lipids, and increases a marker of adipose inflammation, but has no effect on body weight or overall visceral adiposity. Sucrose also decreases corticosterone levels in serum but not in the brain. Sucrose increases progesterone levels in serum and in the brain and increases the brain:serum ratio of progesterone in the mesocorticolimbic system and hypothalamus. These data suggest a dysregulation of systemic and local steroid signalling. Moreover, sucrose decreases tyrosine hydroxylase (TH), a catecholamine-synthetic enzyme, in the medial prefrontal cortex. Finally, sucrose consumption alters the expression pattern of FOSB, a marker of phasic dopamine signalling, in the nucleus accumbens. Overall, chronic consumption of sucrose at a human-relevant level alters metabolism, steroid levels, and brain dopamine signalling in a female rat model. |
| معلومات مُعتمدة: | 168928 Canada CIHR |
| فهرسة مساهمة: | Keywords: glucose tolerance test; inflammation; liver steatosis; mass spectrometry; neurosteroids; steroid profiling; sugar |
| المشرفين على المادة: | 0 (Dietary Sucrose) VTD58H1Z2X (Dopamine) W980KJ009P (Corticosterone) |
| تواريخ الأحداث: | Date Created: 20200301 Date Completed: 20201019 Latest Revision: 20201019 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1530/JOE-19-0386 |
| PMID: | 32112695 |
| قاعدة البيانات: | MEDLINE |
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