دورية أكاديمية
Transmission of hepatitis C virus in HIV-positive and PrEP-using MSM in England.
| العنوان: | Transmission of hepatitis C virus in HIV-positive and PrEP-using MSM in England. |
|---|---|
| المؤلفون: | Bradshaw D; Department of HIV and Sexual Health, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK., Vasylyeva TI; Department of Zoology, University of Oxford, Oxford, UK., Davis C; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK., Pybus OG; Department of Zoology, University of Oxford, Oxford, UK., Thézé J; Department of Zoology, University of Oxford, Oxford, UK., Thomson EC; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK., Martinello M; Kirby Institute, University of New South Wales, Sydney, Australia., Matthews GV; Kirby Institute, University of New South Wales, Sydney, Australia., Burholt R; Brighton and Sussex University Hospitals NHS Trust, Brighton, UK., Gilleece Y; Brighton and Sussex University Hospitals NHS Trust, Brighton, UK., Cooke GS; Imperial College London, London, UK., Page EE; Leeds Teaching Hospitals NHS Trust, Leeds, UK., Waters L; Mortimer Market Centre, London, UK., Nelson M; Department of HIV and Sexual Health, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK. |
| المصدر: | Journal of viral hepatitis [J Viral Hepat] 2020 Jul; Vol. 27 (7), pp. 721-730. Date of Electronic Publication: 2020 Mar 12. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 9435672 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2893 (Electronic) Linking ISSN: 13520504 NLM ISO Abbreviation: J Viral Hepat Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford ; Boston : Blackwell Scientific Publications, 1994- |
| مواضيع طبية MeSH: | HIV Infections* , Pre-Exposure Prophylaxis* , Sexual and Gender Minorities*, Hepatitis C/*transmission, England ; HIV Seropositivity ; Hepacivirus ; Homosexuality, Male ; Humans ; Male ; Phylogeny ; Risk-Taking |
| مستخلص: | We sought to characterize risk factors and patterns of HCV transmission amongst men who have sex with men (MSM). MSM with recently acquired HCV (AHCV) were prospectively recruited ('clinic cohort') between January and September 2017. Clinical data and risk behaviours were identified and blood obtained for HCV whole genome sequencing. Phylogenetic analyses were performed, using sequences from this cohort and two other AHCV cohorts, to identify transmission clusters. Sixteen (40.0%) men in the clinic cohort were HIV-negative MSM. HIV-negative MSM were younger than HIV-positive MSM; most (81.3%) had taken HIV PrEP in the preceding year. Eighteen men (45.0%) reported injection drug use; most (34, 85.0%) reported noninjection drug use in the last year. Most in both groups reported condomless anal sex, fisting and sex in a group environment. Few (7, 17.5%) men thought partners may have had HCV. There were 52 sequences in the HCV genotype 1a phylogeny, 18 from the clinic cohort and 34 from other AHCV cohorts; 47 (90.4%) clustered with ≥1 other sequence. There were 7 clusters of 2-27 sequences; 6 clusters contained HIV-negative and HIV-positive MSM and 1 cluster only HIV-positive MSM. Four of these clusters were part of larger clusters first described in 2007. PrEP-using MSM are at risk of HCV, sharing similar risk factors to HIV-positive MSM. Phylogenetics highlights that PrEP-using and HIV-positive MSM are involved in the same HCV transmission networks. Few men demonstrated HCV awareness and risk reduction strategies should be expanded. (© 2020 John Wiley & Sons Ltd.) |
| References: | Jordan AE, Perlman DC, Neurer J, Smith DJ, Des Jarlais DC, Hagan H. Prevalence of hepatitis C virus infection among HIV+ men who have sex with men: a systematic review and meta-analysis. Int J STD AIDS. 2017;28(2):145-159. Ghisla V, Scherrer AU, Nicca D, Braun DL, Fehr JS. Incidence of hepatitis C in HIV positive and negative men who have sex with men 2000-2016: a systematic review and meta-analysis. Infection. 2017;45(3):309-321. Ingiliz P, Martin TC, Rodger A, et al. HCV reinfection incidence and spontaneous clearance rates in HIV-positive men who have sex with men in Western Europe. J Hepatol. 2017;66(2):282-287. Boerekamps A, Van Den Berk GE, Fanny LN, et al. Declining HCV incidence in Dutch HIV positive men who have sex with men after unrestricted access to HCV therapy. Clin Infect Dis. 2017;66:1360-1365. Garvey LJ, Smith CJ, Stingone C, et al. Fall in HCV incidence in HIV+ MSM in London following wider access to daa therapy. Paper Presented At: Conference On Retroviruses And Opportunistic Infections; 4-7 March, 2019, 2019; Seattle, USA. Jin F, Matthews GV, Grulich AE. Sexual transmission of hepatitis C virus among gay and bisexual men: a systematic review. Sexual Health. 2017;14(1):28-41. Hoornenborg E, Achterbergh RCA, Schim Van Der Loeff MF, et al. Who have sex with men starting pre-exposure prophylaxis (Prep) are at risk of HCV infection: evidence from the amsterdam prep study. Aids. 2017;31:1603-1610. Ramiere C, Charre C, Miailhes P, et al. Patterns of HCV transmission in HIV-infected and HIV-negative men having sex with men. Clin Infect Dis. 2019;69:2127-2135. WHO Global Hepatitis Report. 2017; https://Apps.Who.Int/Iris/Bitstream/Handle/10665/255016/9789241565455-Eng.Pdf;Jsessionid=A47439E1817A394FDE56F81DFE482BD6?Sequence=1. Boesecke C, Singh GKJ, Scholten SH, et al. Telaprevir-containing triple therapy in acute HCV coinfection: the CHAT study. Antivir Ther. 2017;22(7):619-623. Martinello M, Bhagani S, Gane E, et al. Shortened therapy of eight weeks with paritaprevir/ritonavir/ombitasvir and dasabuvir is highly effective in people with recent HCV genotype 1 infection. J Viral Hepat. 2018;25(10):1180-1188. Bradshaw D, Lamoury F, Catlett B, et al. A comparison of seminal hepatitis C virus (HCV) RNA levels during recent and chronic HCV infection in HIV-infected and HIV-uninfected individuals. J Infect Dis. 2015;211(5):736-743. Thomson E, Ip CL, Badhan A, et al. Comparison of next-generation sequencing technologies for comprehensive assessment of full-length hepatitis C viral genomes. J Clin Microbiol. 2016;54(10):2470-2484. Larkin MA, Blackshields G, Brown NP, et al. Clustal W and Clustal X version 2.0. Bioinformatics. 2007;23(21):2947-2948. Kumar S, Stecher G, Tamura K. MEGA7: molecular evolutionary genetics analysis version 7.0 for bigger datasets. Mol Biol Evol. 2016;33(7):1870-1874. Alcantara LC, Cassol S, Libin P, et al. A standardized framework for accurate, high-throughput genotyping of recombinant and non-recombinant viral sequences. Nucleic Acids Res. 2009;37(Web Server):W634-W642. Rozanov M, Plikat U, Chappey C, Kochergin A, Tatusova T. A web-based genotyping resource for viral sequences. Nucleic Acids Res. 2004;32(Web Server):W654-W659. Stamatakis A. Raxml version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. Bioinformatics. 2014;30(9):1312-1313. Rambaut A, Lam TT, Max Carvalho L, Pybus OG. Exploring the temporal structure of heterochronous sequences using tempest (Formerly Path-O-Gen). Virus Evol. 2016;2(1):vew007. Gray RR, Parker J, Lemey P, Salemi M, Katzourakis A, Pybus OG. The mode and tempo of hepatitis C virus evolution within and among hosts. BMC Evol Biol. 2011;11:131. Ragonnet-Cronin M, Hodcroft E, Hue S, et al. Automated analysis of phylogenetic clusters. BMC Bioinform. 2013;14:317. Parker J, Rambaut A, Pybus OG. Correlating viral phenotypes with phylogeny: accounting for phylogenetic uncertainty. Infect Genet Evol. 2008;8(3):239-246. Suchard MA, Lemey P, Baele G, Ayres DL, Drummond AJ, Rambaut A. Bayesian phylogenetic and phylodynamic data integration using BEAST 1.10. Virus Evol. 2018;4(1):Vey016. Iles JC, Raghwani J, Harrison GLA, et al. Phylogeography and epidemic history of hepatitis C virus genotype 4 in Africa. Virology. 2014;464-465:233-243. Rambaut A, Drummond AJ, Xie D, Baele G, Suchard MA. Posterior summarization in Bayesian phylogenetics using tracer 1.7. Syst Biol. 2018;67(5):901-904. Bradshaw D, Raghwani J, Jacka B, et al. Venue-based networks may underpin HCV transmissions amongst HIV-infected gay and bisexual men. Plos One. 2016;11(9):E0162002. Danta M, Brown D, Bhagani S, et al. Recent epidemic of acute hepatitis C virus in HIV-positive men who have sex with men linked to high-risk sexual behaviours. Aids. 2007;21(8):983-991. Martin NK, Thornton A, Hickman M, et al. Can hepatitis C virus (HCV) direct-acting antiviral treatment as prevention reverse the HCV Epidemic among men who have sex with men in the United Kingdom? Epidemiological and modeling insights. Clin Infect Dis. 2016;62(9):1072-1080. Cotte L, Cua E, Reynes J, et al. Hepatitis C virus incidence in HIV-infected and in preexposure prophylaxis (Prep)-using men having sex with men. Liver Int. 2018;38(10):1736-1740. Mcfaul K, Maghlaoui A, Nzuruba M, et al. Acute hepatitis C infection in HIV-negative men who have sex with men. J Viral Hepatitis. 2015;22(6):535-538. Nerlander LMC, Hoots BE, Bradley H, et al. HIV infection among MSM who inject methamphetamine in 8 US cities. Drug Alcohol Depend. 2018;190:216-223. Vanhommerig JW, Lambers FA, Schinkel J, et al. Factors For sexual transmission of hepatitis C virus among human immunodeficiency virus-infected men who have sex with men: a case-control study. Open Forum Infect Dis. 2015;2(3):Ofv115. Scheinmann R, Hagan H, Lelutiu-Weinberger C, et al. Non-injection drug use and hepatitis C virus: a systematic review. Drug Alcohol Depend. 2007;89(1):1-12. Price JC, Mckinney JE, Crouch PC, et al. Sexually acquired hepatitis C infection in HIV-uninfected men who have sex with men using pre-exposure prophylaxis against HIV. J Infect Dis. 2019;219(9):1373-1376. Lambers FA, Prins M, Davidovich U, Stolte IG. High awareness of hepatitis C virus (HCV) but limited knowledge of HCV complications among HIV-positive and HIV-negative men who have sex with men. AIDS Care. 2014;26(4):416-424. Clerc O, Darling K, Calmy A, Dubois-Arber F, Cavassini M. Hepatitis C virus awareness among men who have sex with men in Southwest Switzerland. Sex Transm Dis. 2016;43(1):44-48. Datta J, Reid D, Hughes G, Mercer CH, Wayal S, Weatherburn P. Awareness of and attitudes to sexually transmissible infections among gay men and other men who have sex with men in England: a qualitative study. Sexual Health. 2019;16(1):18. Lattimore S, Thornton A, Delpech V, Elford J. Changing patterns of sexual risk behavior among London gay men: 1998-2008. Sex Transm Dis. 2011;38(3):221-229. Traeger MW, Schroeder SE, Wright EJ, et al. Effects of pre-exposure prophylaxis for the prevention of human immunodeficiency virus infection on sexual risk behavior in men who have sex with men: a systematic review and meta-analysis. Clin Infect Dis. 2018;67(5):676-686. Hess KL, Crepaz N, Rose C, Purcell D, Paz-Bailey G. Trends in sexual behavior among men who have sex with men (MSM) in high-income countries, 1990-2013: a systematic review. AIDS Behav. 2017;21(10):2811-2834. Nash S, Desai S, Croxford S, et al. Progress Towards Ending The HIV Epidemic In The United Kingdom: 2018 Report. In: England PH, Ed2018. Sherman KE, Shire NJ, Rouster SD, et al. Viral kinetics in hepatitis C or hepatitis C/human immunodeficiency virus-infected patients. Gastroenterology. 2005;128(2):313-327. Thomson EC, Nastouli E, Main J, et al. Delayed anti-HCV antibody response in HIV-positive men acutely infected with HCV. Aids. 2009;23(1):89-93. Matthews GV, Pham ST, Hellard M, et al. Patterns and characteristics of hepatitis C transmission clusters among HIV-positive and HIV-negative individuals in the Australian trial in acute hepatitis C. Clin Infect Dis. 2011;52(6):803-811. Van De Laar T, Pybus O, Bruisten S, et al. Evidence of a large, international network of HCV transmission in HIV-positive men who have sex with men. Gastroenterology. 2009;136(5):1609-1617. Danta M, Van De Laar T, Brown D, et al. Evidence of international transmission of HCV in Pan-European study of HIV-positive men who have sex with men (MSM). Hepatology. 2007;46(4):297a-298a. Macgregor L, Martin NK, Mukandavire C, et al. Not biological, factors drive the HCV epidemic among HIV-positive MSM: HCV and HIV modelling analysis including HCV treatment-as-prevention impact. Int J Epidemiol. 2017;46(5):1582-1592. Charre C, Cotte L, Kramer R, et al. Hepatitis C virus spread from HIV-positive to HIV-negative men who have sex with men. Plos One. 2018;13(1):E0190340. BHIVA/BASHH guidelines on the use of HIV pre-exposure prophylaxis (Prep) 2018. 2018; https://Www.Bhiva.Org/File/5b729cd592060/2018-Prep-Guidelines.Pdf. Salazar-Vizcaya L, Wandeler G, Fehr J, et al. Impact of direct-acting antivirals on the Burden Of HCV infection among persons who inject drugs and men who have sex with men in the Swiss HIV cohort study. Open Forum Infect Dis. 2018;5(7):Ofy154. Pradat P, Huleux T, Raffi F, et al. Incidence of new hepatitis C virus infection is still increasing in French MSM living with HIV. Aids. 2018;32(8):1077-1082. |
| معلومات مُعتمدة: | EME/14/02/17 United Kingdom DH_ Department of Health; MC_UU_12014/1 United Kingdom MRC_ Medical Research Council; RP-2016-07-012 United Kingdom DH_ Department of Health |
| فهرسة مساهمة: | Keywords: HIV; hepatitis C; men who have sex with men; pre-exposure prophylaxis |
| تواريخ الأحداث: | Date Created: 20200303 Date Completed: 20210811 Latest Revision: 20210811 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1111/jvh.13286 |
| PMID: | 32115809 |
| قاعدة البيانات: | MEDLINE |
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