دورية أكاديمية
أعرض في EDS

Assessment of superficial and deep retinal vessel density in systemic lupus erythematosus patients using optical coherence tomography angiography.

التفاصيل البيبلوغرافية
العنوان: Assessment of superficial and deep retinal vessel density in systemic lupus erythematosus patients using optical coherence tomography angiography.
المؤلفون: Arfeen SA; Department of Ophthalmology, Kasr Alainy School of Medicine, Cairo University, Cairo, Egypt., Bahgat N; Department of Ophthalmology, Kasr Alainy School of Medicine, Cairo University, Cairo, Egypt., Adel N; Department of Ophthalmology, Kasr Alainy School of Medicine, Cairo University, Cairo, Egypt., Eissa M; Department of Rheumatology and Rehabilitation, Kasr Alainy School of Medicine, Cairo University, Cairo, Egypt., Khafagy MM; Department of Ophthalmology, Kasr Alainy School of Medicine, Cairo University, Cairo, Egypt. mkhafagy@kasralainy.edu.eg.
المصدر: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie [Graefes Arch Clin Exp Ophthalmol] 2020 Jun; Vol. 258 (6), pp. 1261-1268. Date of Electronic Publication: 2020 Mar 11.
نوع المنشور: Comparative Study; Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 8205248 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-702X (Electronic) Linking ISSN: 0721832X NLM ISO Abbreviation: Graefes Arch Clin Exp Ophthalmol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin ; New York : Springer-Verlag, c1982-
مواضيع طبية MeSH: Lupus Erythematosus, Systemic/*physiopathology , Retinal Diseases/*pathology , Retinal Vessels/*pathology, Adult ; Area Under Curve ; Capillaries/diagnostic imaging ; Capillaries/pathology ; Cross-Sectional Studies ; Female ; Fluorescein Angiography ; Fovea Centralis/blood supply ; Humans ; Intraocular Pressure/physiology ; Lupus Erythematosus, Systemic/diagnostic imaging ; Male ; Microvessels/diagnostic imaging ; Microvessels/pathology ; ROC Curve ; Retinal Diseases/diagnostic imaging ; Retinal Vessels/diagnostic imaging ; Tomography, Optical Coherence ; Visual Acuity/physiology ; Young Adult
مستخلص: Purpose: The aim of this study is to evaluate the retinal microvascular density in SLE patients using optical coherence tomography angiography (OCTA) and to correlate vascular density with the disease activity and damage risk.
Methods: Twenty eyes of 20 SLE patients were compared with 20 eyes of normal subjects. The retinal capillary plexuses were examined by OCTA. The disease activity and damage risk were evaluated by the SLEDAI-2 K and SLICC/ACR SDI scoring systems.
Results: No difference was found between SLE patients' central foveal thickness (CFT) and foveal avascular zone (FAZ) area and the normal (P > 0.05). SLE patients had slightly lower superficial vessel densities than normal in the upper and lower macular regions (P < 0.05), sparing the middle sectors (P > 0.05). In the deep plexus, vessel density loss was detected in all sectors (P < 0.001). The vessel density in 300-μm-wide region around the FAZ (FD-300) and the acircularity index (AI) were affected in the SLE in comparison to the normal group (P < 0.05). No significant correlation was found between the SLEDAI-2 k and the retinal vessel density in either layer, while the SLICC/SDI had moderate inverse correlation with vessel density in some sectors (P < 0.05). Receiver operating characteristic (ROC) curve analysis showed that the deep capillary plexus had high sensitivity and specificity for detecting vascular damage in SLE patients.
Conclusions: OCTA permits noninvasive quantitative assessment of retinal vessel density in SLE, allowing early detection of altered retinal circulation. Vessel density could be included in future assessment of SLE activity and damage scores.
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فهرسة مساهمة: Keywords: OCTA; Retinal capillaries; Systemic lupus erythematosus; Vessel density
تواريخ الأحداث: Date Created: 20200313 Date Completed: 20210405 Latest Revision: 20221110
رمز التحديث: 20221213
DOI: 10.1007/s00417-020-04626-7
PMID: 32162113
قاعدة البيانات: MEDLINE
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