دورية أكاديمية

Hyperthyroidism with thyroid cancer: more common than expected?

التفاصيل البيبلوغرافية
العنوان: Hyperthyroidism with thyroid cancer: more common than expected?
المؤلفون: Aksoy SÖ, Sevinç Aİ, Durak MG
المصدر: Annali italiani di chirurgia [Ann Ital Chir] 2020; Vol. 91, pp. 16-22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Casa Editrice Licinio Cappelli Country of Publication: Italy NLM ID: 0372343 Publication Model: Print Cited Medium: Internet ISSN: 2239-253X (Electronic) Linking ISSN: 0003469X NLM ISO Abbreviation: Ann Ital Chir Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Bologna : Casa Editrice Licinio Cappelli
مواضيع طبية MeSH: Hyperthyroidism/*surgery , Thyroid Neoplasms/*epidemiology, Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Hyperthyroidism/complications ; Male ; Middle Aged ; Retrospective Studies ; Thyroid Neoplasms/etiology ; Young Adult
مستخلص: Objective: Hyperthyroidism is a group of diseases with many different etiologies and clinical manifestations. The most common causes include toxic multi-nodular goiter, Graves' disease and toxic adenoma. The prevalence of thyroid cancer developing in patients with hyperthyroidism has gradually increased in recent years. The aim of this study is to detect the incidental thyroid cancer rates in patients who have undergone a surgical operation due to hyperthyroidism, and to specify the patient groups in whom surgical treatment should come into the foreground.
Methods: A total of 591 patients, who had surgical excision of the thyroid due to hyperthyroidism between January 2007 and June 2017, were retrospectively analyzed.
Results: Of all the patients included in the study, 377 (63.7%) had multi-nodular goiter, 132 (22.3%) had Graves' disease, 55 (9.4%) had nodular Graves' disease, and 27 (4.6%) had toxic adenoma. Thyroid cancer was determined in 131 out of 591 patients (22.6%) who were operated. The most common histologic type was thyroid micropapillary carcinoma (65/131; 49.6%). The accompanying pathologies to thyroid cancer were as follows: Toxic multi-nodular goiter (89/131; 67.9%), nodular Graves' disease (24/131; 18.3%), Graves' disease (13/131; 9.9%) and toxic adenoma (5/131; 2.8%).
Discussion: Prevalence of cancer on a background of hyperthyroidism has gradually increased in recent years. It is not realistic to determine thyroid cancer prevalence only based on autopsy examinations. This rate significantly increases in the presence of nodule in clinical studies. Most of the carcinomas are microcarcinomas that do not have lymphovascular invasion and have very low lymph node metastasis. Thus, their treatment is still under debate.
Key Words: Hyperthyroidism Micropapillary Cancer, Thyroid cancer.
فهرسة مساهمة: Local Abstract: [Publisher, Italian] L’ipertiroidismo ha diverse eziologie e differenti manifestazioni cliniche. Le cause più comuni sono il gozzo multi- nodulare tossico, la malattia di Graves e l’adenoma tossico. La prevalenza del cancro alla tiroide che si sviluppa in pazienti con ipertiroidismo è gradualmente aumentata negli ultimi anni. Lo scopo di questo studio è di rilevare i tassi incidentali di cancro alla tiroide in pazienti che hanno subito un intervento chirurgico a causa di ipertiroidismo e di specificare i gruppi di pazienti in cui il trattamento chirurgico dovrebbe essere di primo approccio. La casistica studiata retrospettivamente riguarda 591 pazienti sottoposti ad escissione chirurgica della tiroide a causa di ipertiroidismo tra gennaio 2007 e giugno 2017. Di tutti i pazienti inclusi nello studio, 377 (63,7%) avevano gozzo multi-nodulare, 132 (22,3%) avevano la malattia di Graves, 55 (9,4%) avevano la malattia di Graves nodulare e 27 (4,6%) avevano un adenoma tossico. Il cancro della tiroide è stato individuato 131 sul totale dei pazienti analizzati (22,6%). Il tipo istologico più comune era il carcinoma micropapillare tiroideo (65/131, 49.6%) e le patologie associate al carcinoma tiroideo erano rispettivamente un gozzo multinodulare tossico (89/131; 67,9%), la malattia di Graves nodulare (24/131; 18,3%), la malattia di Graves (13/131; 9,9%) e l’adenoma tossico (5/131; 2,8%). La presenza del cancro su uno sfondo di ipertiroidismo è gradualmente aumentata negli ultimi anni, e non è realistico determinare l’incidenza del cancro tiroideo solo sulla base di esami di autopsia. Questo tasso aumenta significativamente in presenza di noduli negli studi clinici, e la maggior parte dei carcinomi sono microcarcinomi che non presentano invasione linfovascolare e con bassa incidenza di metastasi linfonodali. Pertanto, il loro trattamento è ancora in discussione.
تواريخ الأحداث: Date Created: 20200318 Date Completed: 20210120 Latest Revision: 20220413
رمز التحديث: 20221213
PMID: 32180570
قاعدة البيانات: MEDLINE