دورية أكاديمية
Effects of glyphosate, cypermethrin, and chlorpyrifos on hematological parameters of the tegu lizard (Salvator merianae) in different embryo stages.
| العنوان: | Effects of glyphosate, cypermethrin, and chlorpyrifos on hematological parameters of the tegu lizard (Salvator merianae) in different embryo stages. |
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| المؤلفون: | Mestre AP; Laboratorio de Ecología Molecular Aplicada, Instituto de Ciencias Veterinarias del Litoral (ICiVet Litoral) UNL - CONICET, Esperanza, Argentina; Laboratorio de Genética, Departamento de Ciencias Naturales (FHUC - UNL), CONICET, Santa Fe, Argentina; Laboratorio de Zoología Aplicada: Anexo Vertebrados, Facultad de Humanidades y Ciencias, Universidad Nacional del Litoral, (FHUC - UNL /MMA), Santa Fe, Argentina. Electronic address: anapaulamestre@yahoo.com., Amavet PS; Laboratorio de Genética, Departamento de Ciencias Naturales (FHUC - UNL), CONICET, Santa Fe, Argentina; Laboratorio de Zoología Aplicada: Anexo Vertebrados, Facultad de Humanidades y Ciencias, Universidad Nacional del Litoral, (FHUC - UNL /MMA), Santa Fe, Argentina. Electronic address: pamavet@fhuc.unl.edu.ar., van der Sloot IS; MBO Helicon, Apeldoorn, Netherlands. Electronic address: imreelvdsloot@gmail.com., Carletti JV; Laboratorio de Ecología Molecular Aplicada, Instituto de Ciencias Veterinarias del Litoral (ICiVet Litoral) UNL - CONICET, Esperanza, Argentina; Laboratorio de Genética, Departamento de Ciencias Naturales (FHUC - UNL), CONICET, Santa Fe, Argentina; Laboratorio de Zoología Aplicada: Anexo Vertebrados, Facultad de Humanidades y Ciencias, Universidad Nacional del Litoral, (FHUC - UNL /MMA), Santa Fe, Argentina. Electronic address: julicarletti.21@gmail.com., Poletta GL; Laboratorio de Ecología Molecular Aplicada, Instituto de Ciencias Veterinarias del Litoral (ICiVet Litoral) UNL - CONICET, Esperanza, Argentina; Cátedra de Toxicología, Farmacología y Bioquímica Legal (FBCB-UNL), CONICET, Santa Fe, Argentina. Electronic address: gisepoletta@hotmail.com., Siroski PA; Laboratorio de Ecología Molecular Aplicada, Instituto de Ciencias Veterinarias del Litoral (ICiVet Litoral) UNL - CONICET, Esperanza, Argentina; Laboratorio de Genética, Departamento de Ciencias Naturales (FHUC - UNL), CONICET, Santa Fe, Argentina. Electronic address: cocokaima@hotmail.com. |
| المصدر: | Chemosphere [Chemosphere] 2020 Aug; Vol. 252, pp. 126433. Date of Electronic Publication: 2020 Mar 07. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 0320657 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1298 (Electronic) Linking ISSN: 00456535 NLM ISO Abbreviation: Chemosphere Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Elsevier Science Ltd Original Publication: Oxford, New York, : Pergamon Press. |
| مواضيع طبية MeSH: | Lizards/*physiology , Pesticides/*toxicity, Animals ; Chlorpyrifos/toxicity ; Embryo, Nonmammalian/drug effects ; Embryo, Nonmammalian/physiology ; Embryonic Development ; Glycine/analogs & derivatives ; Glycine/toxicity ; Herbicides/toxicity ; Immune System ; Insecticides/toxicity ; Lizards/blood ; Lizards/embryology ; Pyrethrins/toxicity ; Glyphosate |
| مستخلص: | Different studies have demonstrated effects of pesticides during embryo development in vertebrates and stage-dependent effects, but there is no information concerning this for Salvator merianae. We evaluated the effects of the herbicides Glyphosate Roundup (GLY-RU) and Glyphosate Panzer Gold (GLY-PZ); and the insecticides Chlorpyrifos (CPF) and Cypermethrin (CYP), and their complex mixtures, at different concentrations in hematological parameters of S. merianae embryos at two different development stages. The analyzed parameters were Total and Differential White Blood Cells Count, Heterophils/Lymphocytes index (H/L), Lobularity index, and Natural Antibodies (Nabs titres), as well as growth, embryo mortality and birth delay. Heterophils decreased in the intermediate concentrations tested of CYP and GLY-RU, in animals exposed at 33-days development. Lymphocytes increased in the intermediate concentration tested of GLY-RU, and the H/L index decreased in the maximum concentration tested of GLY-RU. NAbs titres increased in those animals exposed to the maximum CYP concentration tested. However, animals exposed at 3/5-days development showed no differences among treatments in most of the analyzed parameters, suggesting a stage-dependent response. Nevertheless, those animals exposed to GLY-PZ showed lower Nabs titres in relation to negative control. These results suggest effects on different hematological parameters related to the immune system of S. merianae, according to the used pesticide (herbicide or insecticide), its concentration and commercial formulation (GLY-RU or GLY-PZ), and the stages of development of the exposed animals. Our results reveal the importance of carrying out studies that evaluate the effects of permanent exposure of living beings and their environments to these toxics. Competing Interests: Declaration of competing interest None. (Copyright © 2020 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Biomarkers; Hematology; In ovo exposure; Pesticides; Reptiles |
| المشرفين على المادة: | 0 (Herbicides) 0 (Insecticides) 0 (Pesticides) 0 (Pyrethrins) 1TR49121NP (cypermethrin) JCS58I644W (Chlorpyrifos) TE7660XO1C (Glycine) |
| تواريخ الأحداث: | Date Created: 20200318 Date Completed: 20200610 Latest Revision: 20231213 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.chemosphere.2020.126433 |
| PMID: | 32182507 |
| قاعدة البيانات: | MEDLINE |
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