دورية أكاديمية
Lipase C, Hepatic Type -250A/G (rs2070895) Variant Enhances Carotid Atherosclerosis in Normolipidemic and Asymptomatic Individuals from Brazil.
| العنوان: | Lipase C, Hepatic Type -250A/G (rs2070895) Variant Enhances Carotid Atherosclerosis in Normolipidemic and Asymptomatic Individuals from Brazil. |
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| المؤلفون: | Zago VHS; Department of Clinical Pathology, Faculty of Medical Sciences, State University of Campinas, Tessália Vieira de Camargo St, 126, Campinas, São Paulo, 13084-971, Brazil., Parra ES; Department of Clinical Pathology, Faculty of Medical Sciences, State University of Campinas, Tessália Vieira de Camargo St, 126, Campinas, São Paulo, 13084-971, Brazil., Virgínio VWM; Department of Clinical Pathology, Faculty of Medical Sciences, State University of Campinas, Tessália Vieira de Camargo St, 126, Campinas, São Paulo, 13084-971, Brazil., Vendrame F; Department of Clinical Pathology, Faculty of Medical Sciences, State University of Campinas, Tessália Vieira de Camargo St, 126, Campinas, São Paulo, 13084-971, Brazil., Gomes ÉIL; Department of Clinical Pathology, Faculty of Medical Sciences, State University of Campinas, Tessália Vieira de Camargo St, 126, Campinas, São Paulo, 13084-971, Brazil., Scherrer DZ; Department of Clinical Pathology, Faculty of Medical Sciences, State University of Campinas, Tessália Vieira de Camargo St, 126, Campinas, São Paulo, 13084-971, Brazil., Marson FAL; Department of Pediatric, Faculty of Medical Sciences, State University of Campinas, Tessália Vieira de Camargo St, 126, Campinas, São Paulo, 13084-971, Brazil.; Department of Medical Genetics and Genomic Medicine, Faculty of Medical Sciences, State University of Campinas, Tessália Vieira de Camargo St, 126, Campinas, São Paulo, 13084-971, Brazil.; Laboratory of Human and Medical Genetics, Post Graduate Program in Health Science, São Francisco University, São Francisco de Assis Av, 218, Jardim São José, Bragança Paulista, São Paulo, 12916-900, Brazil., de Faria EC; Department of Clinical Pathology, Faculty of Medical Sciences, State University of Campinas, Tessália Vieira de Camargo St, 126, Campinas, São Paulo, 13084-971, Brazil. |
| المصدر: | Lipids [Lipids] 2020 May; Vol. 55 (3), pp. 225-237. Date of Electronic Publication: 2020 Mar 20. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Subscription Services, Inc Country of Publication: United States NLM ID: 0060450 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-9307 (Electronic) Linking ISSN: 00244201 NLM ISO Abbreviation: Lipids Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2018- : Hoboken, NJ : Wiley Subscription Services, Inc. Original Publication: Chicago, American Oil Chemists' Society. |
| مواضيع طبية MeSH: | Polymorphism, Single Nucleotide*, Carotid Artery Diseases/*genetics , Lipase/*genetics, Adult ; Aged ; Asymptomatic Diseases ; Brazil ; Carotid Artery Diseases/blood ; Cholesterol/blood ; Female ; Genetic Association Studies ; Humans ; Lipids/blood ; Male ; Middle Aged ; Young Adult |
| مستخلص: | The common genetic variant in the promoter region of the hepatic lipase gene [LIPC -250G/A(rs2070895)] has an ambiguous association with cardiovascular disease. In this context, our study was performed to identify the relationships between the rs2070895 with carotid atherosclerosis, plasma lipids, and parameters of reverse cholesterol transport. A total of 285 normolipidemic and asymptomatic participants from an initial sample of 598,288 individuals (inclusion criteria: LDL-C ≤130 mg/dL and triglycerides ≤150 mg/dL; age: 20-75 years, both genders; confirmation of clinical, anthropometric and laboratory data; attended all visits; DNA was achieved to perform genetic analysis) were enrolled and the rs2070895 variant was genotyped by TaqMan® OpenArray® Plataform. Carotid intima-media thickness and the screening of atherosclerotic plaques were determined by B-mode ultrasonography. The rs2070895 genotype frequencies were 0.44, 0.41, and 0.15 (GG, GA, and AA, respectively). Logistic regression analysis showed that the risk of having plaques was increased in participants carrying the AA or AG genotypes (OR = 3.90; 95% CI = 1.54-10.33), despite an increase in high-density lipoprotein cholesterol levels, HDL diameter and apolipoprotein A-I, as compared to the GG genotype. Hepatic lipase and endogenous lecithin cholesterol acyl transferase activities were reduced (38% and 19%, respectively) and lipoprotein lipase was increased by 30% (AA vs GG). Our results provide evidence that the AA or AG genotypes of the rs2070895 were associated with carotid atherosclerosis in apparently healthy participants, probably as a consequence of reduced reverse cholesterol transport and accumulation of HDL subfraction 2 rich in triglycerides and depleted in cholesteryl esters that could become dysfunctional. (© 2020 AOCS.) |
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| معلومات مُعتمدة: | 471380/2008-13 International Conselho Nacional de Desenvolvimento Científico e Tecnológico; 2006/60585-9 International Fundação de Amparo à Pesquisa do Estado de São Paulo; 2015/12858-5 International Fundação de Amparo à Pesquisa do Estado de São Paulo |
| فهرسة مساهمة: | Keywords: LIPC; Atherosclerosis; Hepatic lipase; High-density lipoprotein; Lipid |
| المشرفين على المادة: | 0 (LIPC protein, human) 0 (Lipids) 97C5T2UQ7J (Cholesterol) EC 3.1.1.3 (Lipase) |
| تواريخ الأحداث: | Date Created: 20200321 Date Completed: 20210609 Latest Revision: 20210609 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1002/lipd.12232 |
| PMID: | 32196671 |
| قاعدة البيانات: | MEDLINE |
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