دورية أكاديمية
أعرض في EDS

Mending a broken heart: current strategies and limitations of cell-based therapy.

التفاصيل البيبلوغرافية
العنوان: Mending a broken heart: current strategies and limitations of cell-based therapy.
المؤلفون: Liew LC; Disease Modeling and Therapeutics Laboratory, A*STAR Institute of Molecular and Cell Biology, 61 Biopolis Drive Proteos, Singapore, 138673, Singapore., Ho BX; Disease Modeling and Therapeutics Laboratory, A*STAR Institute of Molecular and Cell Biology, 61 Biopolis Drive Proteos, Singapore, 138673, Singapore.; Department of Biological Sciences, National University of Singapore, Singapore, 117543, Singapore., Soh BS; Disease Modeling and Therapeutics Laboratory, A*STAR Institute of Molecular and Cell Biology, 61 Biopolis Drive Proteos, Singapore, 138673, Singapore. bssoh@imcb.a-star.edu.sg.; Department of Biological Sciences, National University of Singapore, Singapore, 117543, Singapore. bssoh@imcb.a-star.edu.sg.; Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China. bssoh@imcb.a-star.edu.sg.
المصدر: Stem cell research & therapy [Stem Cell Res Ther] 2020 Mar 26; Vol. 11 (1), pp. 138. Date of Electronic Publication: 2020 Mar 26.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101527581 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-6512 (Electronic) Linking ISSN: 17576512 NLM ISO Abbreviation: Stem Cell Res Ther Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central
مواضيع طبية MeSH: Myocardial Ischemia* , Pluripotent Stem Cells*, Cell- and Tissue-Based Therapy ; Humans ; Myocytes, Cardiac ; Regenerative Medicine
مستخلص: The versatility of pluripotent stem cells, attributable to their unlimited self-renewal capacity and plasticity, has sparked a considerable interest for potential application in regenerative medicine. Over the past decade, the concept of replenishing the lost cardiomyocytes, the crux of the matter in ischemic heart disease, with pluripotent stem cell-derived cardiomyocytes (PSC-CM) has been validated with promising pre-clinical results. Nevertheless, clinical translation was hemmed in by limitations such as immature cardiac properties, long-term engraftment, graft-associated arrhythmias, immunogenicity, and risk of tumorigenicity. The continuous progress of stem cell-based cardiac therapy, incorporated with tissue engineering strategies and delivery of cardio-protective exosomes, provides an optimistic outlook on the development of curative treatment for heart failure. This review provides an overview and current status of stem cell-based therapy for heart regeneration, with particular focus on the use of PSC-CM. In addition, we also highlight the associated challenges in clinical application and discuss the potential strategies in developing successful cardiac-regenerative therapy.
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فهرسة مساهمة: Keywords: Cardiomyocytes; Cell-based therapy; Exosome; Ischemic heart disease; Pluripotent stem cells
تواريخ الأحداث: Date Created: 20200329 Date Completed: 20210618 Latest Revision: 20210618
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC7098097
DOI: 10.1186/s13287-020-01648-0
PMID: 32216837
قاعدة البيانات: MEDLINE
الوصف
تدمد:1757-6512
DOI:10.1186/s13287-020-01648-0