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The Effects of Eating a High Fat Diet on Sensitivity of Male and Female Rats to Methamphetamine and Dopamine D 1 Receptor Agonist SKF 82958.

التفاصيل البيبلوغرافية
العنوان: The Effects of Eating a High Fat Diet on Sensitivity of Male and Female Rats to Methamphetamine and Dopamine D 1 Receptor Agonist SKF 82958.
المؤلفون: Ramos J; Department of Psychology (J.R., E.J.H., G.F.-R., A.T.G., B.C., A.K.M, N.M.B., K.M.S.), Department of Biological Sciences (A.H.G.), and the Border Biomedical Research Center (K.M.S.), The University of Texas at El Paso, El Paso, Texas., Hardin EJ; Department of Psychology (J.R., E.J.H., G.F.-R., A.T.G., B.C., A.K.M, N.M.B., K.M.S.), Department of Biological Sciences (A.H.G.), and the Border Biomedical Research Center (K.M.S.), The University of Texas at El Paso, El Paso, Texas., Grant AH; Department of Psychology (J.R., E.J.H., G.F.-R., A.T.G., B.C., A.K.M, N.M.B., K.M.S.), Department of Biological Sciences (A.H.G.), and the Border Biomedical Research Center (K.M.S.), The University of Texas at El Paso, El Paso, Texas., Flores-Robles G; Department of Psychology (J.R., E.J.H., G.F.-R., A.T.G., B.C., A.K.M, N.M.B., K.M.S.), Department of Biological Sciences (A.H.G.), and the Border Biomedical Research Center (K.M.S.), The University of Texas at El Paso, El Paso, Texas., Gonzalez AT; Department of Psychology (J.R., E.J.H., G.F.-R., A.T.G., B.C., A.K.M, N.M.B., K.M.S.), Department of Biological Sciences (A.H.G.), and the Border Biomedical Research Center (K.M.S.), The University of Texas at El Paso, El Paso, Texas., Cruz B; Department of Psychology (J.R., E.J.H., G.F.-R., A.T.G., B.C., A.K.M, N.M.B., K.M.S.), Department of Biological Sciences (A.H.G.), and the Border Biomedical Research Center (K.M.S.), The University of Texas at El Paso, El Paso, Texas., Martinez AK; Department of Psychology (J.R., E.J.H., G.F.-R., A.T.G., B.C., A.K.M, N.M.B., K.M.S.), Department of Biological Sciences (A.H.G.), and the Border Biomedical Research Center (K.M.S.), The University of Texas at El Paso, El Paso, Texas., Beltran NM; Department of Psychology (J.R., E.J.H., G.F.-R., A.T.G., B.C., A.K.M, N.M.B., K.M.S.), Department of Biological Sciences (A.H.G.), and the Border Biomedical Research Center (K.M.S.), The University of Texas at El Paso, El Paso, Texas., Serafine KM; Department of Psychology (J.R., E.J.H., G.F.-R., A.T.G., B.C., A.K.M, N.M.B., K.M.S.), Department of Biological Sciences (A.H.G.), and the Border Biomedical Research Center (K.M.S.), The University of Texas at El Paso, El Paso, Texas kserafine@gmail.com.
المصدر: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2020 Jul; Vol. 374 (1), pp. 6-15. Date of Electronic Publication: 2020 Apr 07.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE
أسماء مطبوعة: Publication: 1999- : Bethesda, MD : American Society for Pharmacology and Experimental Therapeutics
Original Publication: Baltimore : Williams & Wilkins
مواضيع طبية MeSH: Benzazepines/*pharmacology , Diet, High-Fat/*adverse effects , Methamphetamine/*pharmacology , Receptors, Dopamine D1/*agonists, Animals ; Blinking/drug effects ; Drug Interactions ; Female ; Gene Expression Regulation/drug effects ; Locomotion/drug effects ; Male ; Rats ; Receptors, Dopamine D1/metabolism ; Receptors, Dopamine D2/metabolism
مستخلص: Rats eating high fat chow are more sensitive to the behavioral effects of dopaminergic drugs, including methamphetamine and the dopamine D 2 /D 3 receptor agonist quinpirole, than rats eating standard chow. However, limited work has explored possible sex differences regarding the impact of diet on drug sensitivity. It is also unknown whether eating high fat chow enhances sensitivity of rats to other dopamine (e.g., D 1 ) receptor agonists. To explore these possibilities, male and female Sprague-Dawley rats eating standard laboratory chow (17% kcal from fat) or high fat chow (60% kcal from fat) were tested once per week for 6 weeks with dopamine D 1 receptor agonist SKF 82958 (0.01-3.2 mg/kg) or methamphetamine (0.1-3.2 mg/kg) using cumulative dosing procedures. Eating high fat chow increased sensitivity of male and female rats to methamphetamine-induced locomotion; however, only female rats eating high fat chow were more sensitive to SKF 82958-induced locomotion. SKF 82958-induced eye blinking was also marginally, although not significantly, enhanced among female rats eating high fat chow, but not males. Further, although dopamine D 2 receptor expression was significantly increased for SKF 82958-treated rats eating high fat chow regardless of sex, no differences were observed in dopamine D 1 receptor expression. Taken together, the present study suggests that although eating high fat chow enhances sensitivity of both sexes to dopaminergic drugs, the mechanism driving this effect might be different for males versus females. These data further demonstrate the importance of studying both sexes simultaneously when investigating factors that influence drug sensitivity. SIGNIFICANCE STATEMENT: Although it is known that diet can impact sensitivity to some dopaminergic drugs, sex differences regarding this effect are not well characterized. This report demonstrates that eating a high fat diet enhances sensitivity to methamphetamine, regardless of sex; however, sensitivity to dopamine D 1 receptor agonist SKF 82958 is increased only among females eating high fat chow, but not males. This suggests that the mechanism(s) driving diet-induced changes in drug sensitivity might be different between sexes.
(Copyright © 2020 by The American Society for Pharmacology and Experimental Therapeutics.)
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معلومات مُعتمدة: R25 DA033613 United States DA NIDA NIH HHS; R25 GM069621 United States GM NIGMS NIH HHS
المشرفين على المادة: 0 (Benzazepines)
0 (Receptors, Dopamine D1)
0 (Receptors, Dopamine D2)
44RAL3456C (Methamphetamine)
80751-65-1 (SK&F 82958)
تواريخ الأحداث: Date Created: 20200409 Date Completed: 20201112 Latest Revision: 20240328
رمز التحديث: 20240329
مُعرف محوري في PubMed: PMC7288732
DOI: 10.1124/jpet.119.263293
PMID: 32265322
قاعدة البيانات: MEDLINE
الوصف
تدمد:1521-0103
DOI:10.1124/jpet.119.263293