دورية أكاديمية
ZEB and Snail expression indicates epithelial-mesenchymal transition in canine melanoma.
| العنوان: | ZEB and Snail expression indicates epithelial-mesenchymal transition in canine melanoma. |
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| المؤلفون: | Veloso ES; Department of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, MG, Brazil., Gonçalves INN; Department of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, MG, Brazil., Silveira TL; Department of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, MG, Brazil., Espirito Santo JT; Department of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, MG, Brazil., Figueiredo LV; Department of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, MG, Brazil., Varaschin MS; Department of Veterinary Medicine, Federal University of Lavras, MG, Brazil., Cassali GD; Department of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, MG, Brazil., Del Puerto HL; Department of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, MG, Brazil., Ferreira E; Department of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, MG, Brazil. Electronic address: enioferreira@ufmg.br. |
| المصدر: | Research in veterinary science [Res Vet Sci] 2020 Aug; Vol. 131, pp. 7-14. Date of Electronic Publication: 2020 Apr 06. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: British Veterinary Association Country of Publication: England NLM ID: 0401300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2661 (Electronic) Linking ISSN: 00345288 NLM ISO Abbreviation: Res Vet Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : British Veterinary Association Original Publication: Oxford. |
| مواضيع طبية MeSH: | Dog Diseases/*metabolism , Epithelial-Mesenchymal Transition/*physiology , Melanoma/*veterinary , Skin Neoplasms/*veterinary , Snail Family Transcription Factors/*metabolism , Zinc Finger E-box-Binding Homeobox 1/*metabolism, Animals ; Cadherins/metabolism ; Cell Adhesion ; Cell Movement ; Dog Diseases/genetics ; Dogs ; Gene Expression Regulation, Neoplastic ; Humans ; Melanoma/metabolism ; Mouth Neoplasms/metabolism ; Mouth Neoplasms/pathology ; Mouth Neoplasms/veterinary ; Skin Neoplasms/metabolism ; Skin Neoplasms/pathology ; Snail Family Transcription Factors/genetics ; Transcription Factors/metabolism ; Tumor Microenvironment ; Zinc Finger E-box-Binding Homeobox 1/genetics |
| مستخلص: | Melanoma progression is associated with the epithelial-mesenchymal transition (EMT) when tumor cells reduce E-cadherin and increase N-cadherin expression resulting in an escape from the microenvironment via loss of cellular adhesion and gain of motility. Transcription factor proteins Snail and ZEB trigger EMT by repression of epithelial markers and activation of mesenchymal properties. This study evaluated E-cadherin, N-cadherin, Snail, ZEB1 and ZEB2 expression by IHC and investigated their relationship with morphological characteristics in cutaneous and oral canine melanoma. Results from melanoma cases demonstrated E-cadherin expression in 45% (9/20) of oral and 58% (22/38) of cutaneous tumors, while N-cadherin expression was observed in 95% (18/19) of oral and 92% (34/37) of cutaneous melanoma. Cytoplasmic and nuclear N-cadherin expression was positively correlated with ZEB1 expression, while the cell membrane N-cadherin expression was positively correlated with ZEB2. In addition, an increase in nuclear N-cadherin expression was associated with reduced Snail expression in cutaneous melanoma and an increase in Snail expression in oral melanoma, indicating that the correlation between N-cadherin and Snail expression is coincident with tumor location. Our data suggest that ZEB family protein is associated with N-cadherin translocation from cell membrane to the cytoplasm and nuclei, and may act as important transcription factors of EMT regulation in canine melanoma. Competing Interests: Declaration of Competing Interest The authors have no competing interests. (Copyright © 2020 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Cadherins; Epithelium-mesenchymal transition; Melanoma; ZEB |
| المشرفين على المادة: | 0 (Cadherins) 0 (Snail Family Transcription Factors) 0 (Transcription Factors) 0 (Zinc Finger E-box-Binding Homeobox 1) |
| تواريخ الأحداث: | Date Created: 20200413 Date Completed: 20201016 Latest Revision: 20201016 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.rvsc.2020.04.007 |
| PMID: | 32278962 |
| قاعدة البيانات: | MEDLINE |
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