دورية أكاديمية
أعرض في EDS

The histone deacetylase complex MiDAC regulates a neurodevelopmental gene expression program to control neurite outgrowth.

التفاصيل البيبلوغرافية
العنوان: The histone deacetylase complex MiDAC regulates a neurodevelopmental gene expression program to control neurite outgrowth.
المؤلفون: Mondal B; Department of Cell & Molecular Biology, St. Jude Children's Research Hospital, Memphis, United States., Jin H; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, United States., Kallappagoudar S; Department of Cell & Molecular Biology, St. Jude Children's Research Hospital, Memphis, United States., Sedkov Y; Department of Cell & Molecular Biology, St. Jude Children's Research Hospital, Memphis, United States., Martinez T; Department of Cell & Molecular Biology, St. Jude Children's Research Hospital, Memphis, United States., Sentmanat MF; Genome Engineering & iPS Center, Department of Genetics, Washington University, St. Louis, United States., Poet GJ; Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, United States., Li C; Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, United States., Fan Y; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, United States., Pruett-Miller SM; Department of Cell & Molecular Biology, St. Jude Children's Research Hospital, Memphis, United States., Herz HM; Department of Cell & Molecular Biology, St. Jude Children's Research Hospital, Memphis, United States.
المصدر: ELife [Elife] 2020 Apr 16; Vol. 9. Date of Electronic Publication: 2020 Apr 16.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
مواضيع طبية MeSH: Gene Expression Regulation/*physiology , Histone Deacetylases/*metabolism , Neuronal Outgrowth/*physiology, Animals ; Cell Differentiation/physiology ; DNA Methylation/physiology ; Male ; Membrane Proteins/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Netrin-1/metabolism
مستخلص: The mitotic deacetylase complex (MiDAC) is a recently identified histone deacetylase (HDAC) complex. While other HDAC complexes have been implicated in neurogenesis, the physiological role of MiDAC remains unknown. Here, we show that MiDAC constitutes an important regulator of neural differentiation. We demonstrate that MiDAC functions as a modulator of a neurodevelopmental gene expression program and binds to important regulators of neurite outgrowth. MiDAC upregulates gene expression of pro-neural genes such as those encoding the secreted ligands SLIT3 and NETRIN1 (NTN1) by a mechanism suggestive of H4K20ac removal on promoters and enhancers. Conversely, MiDAC inhibits gene expression by reducing H3K27ac on promoter-proximal and -distal elements of negative regulators of neurogenesis. Furthermore, loss of MiDAC results in neurite outgrowth defects that can be rescued by supplementation with SLIT3 and/or NTN1. These findings indicate a crucial role for MiDAC in regulating the ligands of the SLIT3 and NTN1 signaling axes to ensure the proper integrity of neurite development.
Competing Interests: BM, HJ, SK, YS, TM, MS, GP, CL, YF, SP, HH No competing interests declared
(© 2020, Mondal et al.)
References: Stem Cells Int. 2017;2017:1021240. (PMID: 28337219)
Cold Spring Harb Perspect Biol. 2010 May;2(5):a001941. (PMID: 20452961)
Biochem Soc Trans. 2013 Jun;41(3):741-9. (PMID: 23697933)
Genes Dev. 1998 Mar 15;12(6):797-805. (PMID: 9512514)
Methods. 2001 Dec;25(4):402-8. (PMID: 11846609)
Nature. 1998 Apr 23;392(6678):831-5. (PMID: 9572144)
Nat Neurosci. 2011 Apr;14(4):437-41. (PMID: 21423191)
Mod Pathol. 2016 Apr;29(4):359-69. (PMID: 26892443)
Nat Neurosci. 2011 Apr;14(4):429-36. (PMID: 21423190)
PLoS One. 2009 Aug 21;4(8):e6724. (PMID: 19696928)
Trends Pharmacol Sci. 2017 Apr;38(4):363-377. (PMID: 28139258)
Sci Rep. 2016 Nov 07;6:36491. (PMID: 27819291)
Cell. 2015 Oct 22;163(3):712-23. (PMID: 26496610)
Development. 2016 Sep 1;143(17):3037-44. (PMID: 27578174)
Cell. 2009 Sep 4;138(5):1019-31. (PMID: 19698979)
J Biol Chem. 2008 Dec 12;283(50):35283-94. (PMID: 18849567)
Genes Dev. 2010 Mar 1;24(5):455-69. (PMID: 20194438)
PLoS Genet. 2011 May;7(5):e1002065. (PMID: 21573134)
Curr Biol. 2005 Aug 9;15(15):1413-9. (PMID: 16085495)
J Mol Endocrinol. 2004 Apr;32(2):557-69. (PMID: 15072559)
Elife. 2020 Apr 16;9:. (PMID: 32297854)
BMC Genomics. 2011 Jan 12;12:24. (PMID: 21226904)
Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14895-900. (PMID: 8962152)
Med Res Rev. 2019 Jan;39(1):386-403. (PMID: 29785841)
Nat Neurosci. 2009 Jul;12(7):829-38. (PMID: 19503085)
Annu Rev Biochem. 2007;76:75-100. (PMID: 17362198)
J Biol Chem. 2002 Oct 18;277(42):39144-55. (PMID: 12101186)
Front Cell Neurosci. 2017 Nov 20;11:359. (PMID: 29209173)
Cell. 2015 Jul 16;162(2):425-440. (PMID: 26186194)
Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9873-8. (PMID: 10449787)
Mol Cell Biol. 2005 Jun;25(11):4335-48. (PMID: 15899840)
Genes Cells. 2015 Mar;20(3):242-54. (PMID: 25619743)
Annu Rev Cell Dev Biol. 2016 Oct 6;32:577-608. (PMID: 27576119)
Nat Neurosci. 2010 Feb;13(2):180-9. (PMID: 20037577)
Sci Rep. 2016 Apr 11;6:24318. (PMID: 27064113)
Nat Genet. 2019 Jun;51(6):973-980. (PMID: 31133750)
Nat Biotechnol. 2011 Mar;29(3):255-65. (PMID: 21258344)
Nat Commun. 2016 Jan 22;7:10481. (PMID: 26795843)
Neural Dev. 2015 May 02;10:13. (PMID: 25934499)
Signal Transduct Target Ther. 2018 Oct 19;3:28. (PMID: 30345081)
Sci Rep. 2018 Sep 12;8(1):13712. (PMID: 30209338)
Mol Cell Biol. 2006 Oct;26(20):7632-44. (PMID: 17015480)
Neuron. 2014 Dec 17;84(6):1258-72. (PMID: 25433640)
Front Neurosci. 2011 Mar 16;5:35. (PMID: 21441990)
Cell Rep. 2016 Nov 1;17(6):1683-1698. (PMID: 27806305)
PLoS One. 2012;7(2):e32087. (PMID: 22384148)
Lab Invest. 2018 Aug;98(8):980-988. (PMID: 29855544)
Mol Cell. 2011 Aug 5;43(3):406-17. (PMID: 21816347)
Nature. 2009 May 7;459(7243):55-60. (PMID: 19424149)
Development. 2011 Jun;138(11):2153-69. (PMID: 21558366)
Nature. 2012 Feb 29;483(7388):222-6. (PMID: 22388814)
Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3841-6. (PMID: 25755260)
Nucleic Acids Res. 2015 Feb 27;43(4):2033-44. (PMID: 25653165)
J Biol Chem. 2001 Sep 7;276(36):33881-92. (PMID: 11349124)
Mol Syst Biol. 2013;9:672. (PMID: 23752268)
Mol Cell Biol. 2006 Nov;26(21):7913-28. (PMID: 16940178)
Proc Natl Acad Sci U S A. 2009 May 12;106(19):7876-81. (PMID: 19380719)
Nat Protoc. 2006;1(2):729-48. (PMID: 17406303)
Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12845-50. (PMID: 8917507)
Nature. 1999 Oct 14;401(6754):670-7. (PMID: 10537105)
J Biol Chem. 1997 Oct 31;272(44):28001-7. (PMID: 9346952)
PLoS One. 2013 Jul 10;8(7):e66710. (PMID: 23874396)
Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13708-13. (PMID: 11095743)
Genes Dev. 2012 Mar 1;26(5):445-60. (PMID: 22357600)
Mol Autism. 2017 Aug 3;8:43. (PMID: 28785396)
Cell Stem Cell. 2009 Nov 6;5(5):515-26. (PMID: 19896442)
Nat Protoc. 2008;3(6):1032-45. (PMID: 18536650)
Cancer Cell. 2016 Jan 11;29(1):5-16. (PMID: 26766587)
معلومات مُعتمدة: R00 CA181506 United States CA NCI NIH HHS; R25 CA023944 United States CA NCI NIH HHS
فهرسة مساهمة: Keywords: DNTTIP1; ELMSAN1/MIDEAS; H3K27 acetylation; H4K20 acetylation; HDAC1; SLIT and NETRIN signaling pathways; chromosomes; gene expression; mitotic deacetylase complex MiDAC; mouse; neurite ourgrowth; neuroscience
سلسلة جزيئية: GEO GSE131062; GSE55437
المشرفين على المادة: 0 (Membrane Proteins)
0 (Slit3 protein, mouse)
158651-98-0 (Netrin-1)
EC 3.5.1.98 (Histone Deacetylases)
تواريخ الأحداث: Date Created: 20200417 Date Completed: 20210331 Latest Revision: 20210331
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7192582
DOI: 10.7554/eLife.57519
PMID: 32297854
قاعدة البيانات: MEDLINE
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