دورية أكاديمية
أعرض في EDS

TRPM6 and TRPM7: Novel players in cell intercalation during vertebrate embryonic development.

التفاصيل البيبلوغرافية
العنوان: TRPM6 and TRPM7: Novel players in cell intercalation during vertebrate embryonic development.
المؤلفون: Runnels LW; Department of Pharmacology, Rutgers-Robert Wood Johnson Medical School, Piscataway, New Jersey, USA., Komiya Y; Department of Pharmacology, Rutgers-Robert Wood Johnson Medical School, Piscataway, New Jersey, USA.; Faculty of Industrial Science and Technology, Tokyo University of Science, Yamakoshi-gun, Hokkaido, Japan.
المصدر: Developmental dynamics : an official publication of the American Association of Anatomists [Dev Dyn] 2020 Aug; Vol. 249 (8), pp. 912-923. Date of Electronic Publication: 2020 May 26.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 9201927 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0177 (Electronic) Linking ISSN: 10588388 NLM ISO Abbreviation: Dev Dyn Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Wiley, c1992-
مواضيع طبية MeSH: Gene Expression Regulation, Developmental*, Magnesium/*chemistry , Protein Serine-Threonine Kinases/*physiology , TRPM Cation Channels/*physiology , Xenopus Proteins/*physiology , Xenopus laevis/*metabolism, 3T3 Cells ; Animals ; Cell Movement ; Embryonic Development ; Humans ; Ions ; Magnesium/metabolism ; Mice ; Neural Plate/metabolism ; Neural Tube/metabolism ; Neural Tube Defects/genetics ; Neural Tube Defects/metabolism ; Neurulation ; Protein Domains ; Protein Serine-Threonine Kinases/genetics ; Signal Transduction ; TRPM Cation Channels/genetics ; TRPM Cation Channels/metabolism ; Xenopus Proteins/genetics ; Zebrafish
مستخلص: A common theme in organogenesis is how the final structure of organs emerge from epithelial tube structures, with the formation of the neural tube being one of the best examples. Two types of cell movements co-occur during neural tube closure involving the migration of cells toward the midline of the embryo (mediolateral intercalation or convergent extension) as well as the deep movement of cells from inside the embryo to the outside of the lateral side of the neural plate (radial intercalation). Failure of either type of cell movement will prevent neural tube closure, which can produce a range of neural tube defects (NTDs), a common congenital disease in humans. Numerous studies have identified signaling pathways that regulate mediolateral intercalation during neural tube closure. Less understood are the pathways that govern radial intercalation. Using the Xenopus laevis system, our group reported the identification of transient receptor potential (TRP) channels, TRPM6 and TRPM7, and the Mg 2+ ion they conduct, as novel and key factors regulating both mediolateral and radial intercalation during neural tube closure. Here we broadly discuss tubulogenesis and cell intercalation from the perspective of neural tube closure and the respective roles of TRPM7 and TRPM6 in this critical embryonic process.
(© 2020 Wiley Periodicals, Inc.)
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معلومات مُعتمدة: R01 GM080753 United States GM NIGMS NIH HHS; R03 HD096365 United States HD NICHD NIH HHS
فهرسة مساهمة: Keywords: TRPM6; TRPM7; Xenopus; cell intercalation; magnesium; neural tube closure
المشرفين على المادة: 0 (Ions)
0 (TRPM Cation Channels)
0 (TRPM6 protein, human)
0 (TRPM7 protein, Xenopus)
0 (Trpm6 protein, mouse)
0 (Xenopus Proteins)
EC 2.7.1.- (Trpm7 protein, mouse)
EC 2.7.11.1 (Protein Serine-Threonine Kinases)
EC 2.7.11.1 (TRPM7 protein, human)
I38ZP9992A (Magnesium)
تواريخ الأحداث: Date Created: 20200422 Date Completed: 20210830 Latest Revision: 20230621
رمز التحديث: 20240829
DOI: 10.1002/dvdy.182
PMID: 32315468
قاعدة البيانات: MEDLINE
الوصف
تدمد:1097-0177
DOI:10.1002/dvdy.182