دورية أكاديمية
COVID-19-related Genes in Sputum Cells in Asthma. Relationship to Demographic Features and Corticosteroids.
| العنوان: | COVID-19-related Genes in Sputum Cells in Asthma. Relationship to Demographic Features and Corticosteroids. |
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| المؤلفون: | Peters MC; Division of Pulmonary and Critical Care Medicine, Department of Medicine and the Cardiovascular Research Institute, University of California San Francisco, San Francisco, California., Sajuthi S; Center for Genes, Environment, and Health and., Deford P; Center for Genes, Environment, and Health and., Christenson S; Division of Pulmonary and Critical Care Medicine, Department of Medicine and the Cardiovascular Research Institute, University of California San Francisco, San Francisco, California., Rios CL; Center for Genes, Environment, and Health and., Montgomery MT; Center for Genes, Environment, and Health and., Woodruff PG; Division of Pulmonary and Critical Care Medicine, Department of Medicine and the Cardiovascular Research Institute, University of California San Francisco, San Francisco, California., Mauger DT; Division of Statistics and Bioinformatics, Department of Public Health Sciences, Pennsylvania State University, Hershey, Pennsylvania., Erzurum SC; Department of Pathobiology, Cleveland Clinic, Cleveland, Ohio., Johansson MW; Department of Biomolecular Chemistry and., Denlinger LC; Division of Allergy, Pulmonary, and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin., Jarjour NN; Division of Allergy, Pulmonary, and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin., Castro M; Division of Allergy, Immunology, and Pulmonary Medicine, University of Kansas, Kansas City, Kansas., Hastie AT; Department of Internal Medicine, Pulmonary Section, School of Medicine, Wake Forest University, Winston-Salem, North Carolina., Moore W; Department of Internal Medicine, Pulmonary Section, School of Medicine, Wake Forest University, Winston-Salem, North Carolina., Ortega VE; Department of Internal Medicine, Pulmonary Section, School of Medicine, Wake Forest University, Winston-Salem, North Carolina., Bleecker ER; Division of Genetics, Genomics, and Precision Medicine, Department of Medicine, University of Arizona, Tucson, Arizona., Wenzel SE; Pulmonary, Allergy, and Critical Care Medicine Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Israel E; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; and., Levy BD; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; and., Seibold MA; Center for Genes, Environment, and Health and.; Department of Pediatrics, National Jewish Health, Denver, Colorado.; Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado-Anschutz Medical Campus, Aurora, Colorado., Fahy JV; Division of Pulmonary and Critical Care Medicine, Department of Medicine and the Cardiovascular Research Institute, University of California San Francisco, San Francisco, California. |
| المصدر: | American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2020 Jul 01; Vol. 202 (1), pp. 83-90. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Thoracic Society Country of Publication: United States NLM ID: 9421642 Publication Model: Print Cited Medium: Internet ISSN: 1535-4970 (Electronic) Linking ISSN: 1073449X NLM ISO Abbreviation: Am J Respir Crit Care Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2000- : New York, NY : American Thoracic Society Original Publication: New York, NY : American Lung Association, c1994- |
| مواضيع طبية MeSH: | Asthma* , Coronavirus* , Coronavirus Infections* , Pandemics* , Pneumonia, Viral*, Adrenal Cortex Hormones ; Betacoronavirus ; COVID-19 ; Demography ; Humans ; Male ; Prospective Studies ; SARS-CoV-2 ; Sputum |
| مستخلص: | Rationale: Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). ACE2 (angiotensin-converting enzyme 2), and TMPRSS2 (transmembrane protease serine 2) mediate viral infection of host cells. We reasoned that differences in ACE2 or TMPRSS2 gene expression in sputum cells among patients with asthma may identify subgroups at risk for COVID-19 morbidity. Objectives: To determine the relationship between demographic features and sputum ACE2 and TMPRSS2 gene expression in asthma. Methods : We analyzed gene expression for ACE2 and TMPRSS2, and for ICAM-1 (intercellular adhesion molecule 1) (rhinovirus receptor as a comparator) in sputum cells from 330 participants in SARP-3 (Severe Asthma Research Program-3) and 79 healthy control subjects. Measurements and Main Results: Gene expression of ACE2 was lower than TMPRSS2, and expression levels of both genes were similar in asthma and health. Among patients with asthma, male sex, African American race, and history of diabetes mellitus were associated with higher expression of ACE2 and TMPRSS2. Use of inhaled corticosteroids (ICS) was associated with lower expression of ACE2 and TMPRSS2, but treatment with triamcinolone acetonide did not decrease expression of either gene. These findings differed from those for ICAM-1, where gene expression was increased in asthma and less consistent differences were observed related to sex, race, and use of ICS. Conclusions: Higher expression of ACE2 and TMPRSS2 in males, African Americans, and patients with diabetes mellitus provides rationale for monitoring these asthma subgroups for poor COVID-19 outcomes. The lower expression of ACE2 and TMPRSS2 with ICS use warrants prospective study of ICS use as a predictor of decreased susceptibility to SARS-CoV-2 infection and decreased COVID-19 morbidity. |
| التعليقات: | Comment in: Am J Respir Crit Care Med. 2020 Jul 1;202(1):8-10. doi: 10.1164/rccm.202005-1651ED. (PMID: 32437628) Erratum in: Am J Respir Crit Care Med. 2020 Dec 15;202(12):1744-1746. doi: 10.1164/rccm.v202erratum7. (PMID: 33320072) |
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| معلومات مُعتمدة: | R01 HL115118 United States HL NHLBI NIH HHS; U10 HL109257 United States HL NHLBI NIH HHS; K23 HL138303 United States HL NHLBI NIH HHS; P01 HL107202 United States HL NHLBI NIH HHS; P01 HL128191 United States HL NHLBI NIH HHS; K24 HL137013 United States HL NHLBI NIH HHS; U10 HL109250 United States HL NHLBI NIH HHS; R01 HL135156 United States HL NHLBI NIH HHS; P30 DK098722 United States DK NIDDK NIH HHS; U10 HL109164 United States HL NHLBI NIH HHS; U10 HL109086 United States HL NHLBI NIH HHS; U10 HL109168 United States HL NHLBI NIH HHS; R01 HL080414 United States HL NHLBI NIH HHS; U10 HL109172 United States HL NHLBI NIH HHS; R01 HL122531 United States HL NHLBI NIH HHS; U19 AI077439 United States AI NIAID NIH HHS; UL1 TR002366 United States TR NCATS NIH HHS; U10 HL109152 United States HL NHLBI NIH HHS; U10 HL109146 United States HL NHLBI NIH HHS; P01 HL132821 United States HL NHLBI NIH HHS; R01 MD010443 United States MD NIMHD NIH HHS |
| فهرسة مساهمة: | Keywords: ACE2; COVID-19; SARS-CoV-2; TMPRSS2; asthma |
| المشرفين على المادة: | 0 (Adrenal Cortex Hormones) |
| تواريخ الأحداث: | Date Created: 20200430 Date Completed: 20200708 Latest Revision: 20240922 |
| رمز التحديث: | 20240922 |
| مُعرف محوري في PubMed: | PMC7328313 |
| DOI: | 10.1164/rccm.202003-0821OC |
| PMID: | 32348692 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1535-4970 |
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| DOI: | 10.1164/rccm.202003-0821OC |