دورية أكاديمية
Calbindin expression in adult vestibular epithelia.
| العنوان: | Calbindin expression in adult vestibular epithelia. |
|---|---|
| المؤلفون: | Prins TJ; Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Box 951624, Los Angeles, CA, 90095-1624, USA.; Department of Integrative Biology and Physiology, UCLA, Los Angeles, CA, 90095, USA., Myers ZA; Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Box 951624, Los Angeles, CA, 90095-1624, USA., Saldate JJ; Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Box 951624, Los Angeles, CA, 90095-1624, USA., Hoffman LF; Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Box 951624, Los Angeles, CA, 90095-1624, USA. lfh@g.ucla.edu.; Brain Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. lfh@g.ucla.edu. |
| المصدر: | Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology [J Comp Physiol A Neuroethol Sens Neural Behav Physiol] 2020 Jul; Vol. 206 (4), pp. 623-637. Date of Electronic Publication: 2020 Apr 29. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: Germany NLM ID: 101141792 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1351 (Electronic) Linking ISSN: 03407594 NLM ISO Abbreviation: J Comp Physiol A Neuroethol Sens Neural Behav Physiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin ; New York : Springer, c2001- |
| مواضيع طبية MeSH: | Calbindin 1/*biosynthesis , Calbindin 2/*biosynthesis , Calcium-Binding Proteins/*metabolism , Hair Cells, Auditory/*metabolism , Neuroepithelial Cells/*metabolism , Vestibule, Labyrinth/*metabolism, Animals ; Calbindin 1/metabolism ; Calbindin 2/metabolism ; Cell Polarity/physiology ; Hair Cells, Auditory/cytology ; Mice, Inbred C57BL ; Neuroepithelial Cells/cytology ; Vestibule, Labyrinth/cytology |
| مستخلص: | The mammalian vestibular epithelia exhibit a remarkably stereotyped organization featuring cellular characteristics under planar cell polarity (PCP) control. PCP mechanisms are responsible for the organization of hair cell morphologic polarization vectors, and are thought to be responsible for the postsynaptic expression of the calcium-binding protein calretinin that defines the utricular striola and cristae central zone. However, recent analyses revealed that subtle differences in the topographic expression of oncomodulin, another calcium-binding protein, reflects heterogeneous factors driving the subtle variations in expression. Calbindin represents a third calcium-binding protein that has been previously described to be expressed in both hair cells and afferent calyces in proximity to the utricular striola and crista central zone. The objective of the present investigation was to determine calbindin's topographic pattern of expression to further elucidate the extent to which PCP mechanisms might exert control over the organization of vestibular neuroepithelia. The findings revealed that calbindin exhibited an expression pattern strikingly similar to oncomodulin. However, within calyces of the central zone calbindin was colocalized with calretinin. These results indicate that organizational features of vestibular epithelia are governed by a suite of factors that include PCP mechanisms as well others yet to be defined. |
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| فهرسة مساهمة: | Keywords: Calretinin; Calyx; Crista; Oncomodulin; Utricle |
| المشرفين على المادة: | 0 (Calb1 protein, mouse) 0 (Calb2 protein, mouse) 0 (Calbindin 1) 0 (Calbindin 2) 0 (Calcium-Binding Proteins) 0 (oncomodulin) |
| تواريخ الأحداث: | Date Created: 20200501 Date Completed: 20210907 Latest Revision: 20211017 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1007/s00359-020-01418-6 |
| PMID: | 32350587 |
| قاعدة البيانات: | MEDLINE |
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