دورية أكاديمية
Divergent T follicular helper cell requirement for IgA and IgE production to peanut during allergic sensitization.
| العنوان: | Divergent T follicular helper cell requirement for IgA and IgE production to peanut during allergic sensitization. |
|---|---|
| المؤلفون: | Zhang B; Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA.; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, 06520, USA., Liu E; Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA.; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, 06520, USA.; Section of Rheumatology, Allergy and Immunology, Yale University School of Medicine, New Haven, CT, 06520, USA., Gertie JA; Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA.; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, 06520, USA., Joseph J; Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA., Xu L; Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA.; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, 06520, USA., Pinker EY; Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA.; Columbia University, New York, NY 10027, USA., Waizman DA; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, 06520, USA., Catanzaro J; Department of Pediatrics, Yale University School of Medicine, New Haven, CT, 06520, USA.; Section of Pulmonology, Allergy, Immunology and Sleep Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA., Hamza KH; Department for Experimental Medicine, Immunology Section, Lund University, Lund 221 84, Sweden., Lahl K; Department for Experimental Medicine, Immunology Section, Lund University, Lund 221 84, Sweden.; Division of Biopharma, Institute for Health Technology, Technical University of Denmark, 2800 Kongens Lyngby, Denmark., Gowthaman U; Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA.; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, 06520, USA., Eisenbarth SC; Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA. stephanie.eisenbarth@yale.edu.; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, 06520, USA.; Section of Rheumatology, Allergy and Immunology, Yale University School of Medicine, New Haven, CT, 06520, USA. |
| المصدر: | Science immunology [Sci Immunol] 2020 May 08; Vol. 5 (47). |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : American Association for the Advancement of Science, [2016]- |
| مواضيع طبية MeSH: | Allergens/*immunology , Immunoglobulin A/*biosynthesis , Immunoglobulin E/*biosynthesis , Peanut Hypersensitivity/*immunology , T-Lymphocytes, Helper-Inducer/*immunology, Animals ; Female ; Immunoglobulin A/immunology ; Immunoglobulin E/immunology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout |
| مستخلص: | Immunoglobulin A (IgA) is the dominant antibody isotype in the gut and has been shown to regulate microbiota. Mucosal IgA is also widely believed to prevent food allergens from penetrating the gut lining. Even though recent work has elucidated how bacteria-reactive IgA is induced, little is known about how IgA to food antigens is regulated. Although IgA is presumed to be induced in a healthy gut at steady state via dietary exposure, our data do not support this premise. We found that daily food exposure only induced low-level, cross-reactive IgA in a minority of mice. In contrast, induction of significant levels of peanut-specific IgA strictly required a mucosal adjuvant. Although induction of peanut-specific IgA required T cells and CD40L, it was T follicular helper (T (Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.) |
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| معلومات مُعتمدة: | R01 AI108829 United States AI NIAID NIH HHS; R01 AI136942 United States AI NIAID NIH HHS; UL1 TR001863 United States TR NCATS NIH HHS |
| المشرفين على المادة: | 0 (Allergens) 0 (Immunoglobulin A) 37341-29-0 (Immunoglobulin E) |
| تواريخ الأحداث: | Date Created: 20200510 Date Completed: 20201231 Latest Revision: 20211022 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC8518330 |
| DOI: | 10.1126/sciimmunol.aay2754 |
| PMID: | 32385053 |
| قاعدة البيانات: | MEDLINE |
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