دورية أكاديمية
Lungs as target of COVID-19 infection: Protective common molecular mechanisms of vitamin D and melatonin as a new potential synergistic treatment.
| العنوان: | Lungs as target of COVID-19 infection: Protective common molecular mechanisms of vitamin D and melatonin as a new potential synergistic treatment. |
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| المؤلفون: | Martín Giménez VM; Institute of Research in Chemical Sciences, School of Chemical and Technological Sciences, Cuyo Catholic University, San Juan, Argentina., Inserra F; Maimónides University, Buenos Aires, Argentina., Tajer CD; Department of Cardiovascular Disease, Hospital de Alta Complejidad El Cruce, Calchaqui 5401, Florencio Varela, Provincia de Buenos Aires 1418857983, Argentina., Mariani J; Department of Cardiology, Hospital El Cruce Néstor C. Kirchner, Av. Calchaquí 5401, Florencio Varela, Buenos Aires 1888, Argentina., Ferder L; Maimónides University, Buenos Aires, Argentina., Reiter RJ; Department of Cellular and Structural Biology, University of Texas Health Science at San Antonio, San Antonio, TX, USA., Manucha W; Pathology Department, Pharmacology Area Medical Sciences College, National University of Cuyo, Mendoza, CP5500, Argentina; National Scientific and Technical Research Council, Institute of Medical and Experimental Biology of Cuyo, Mendoza, Argentina. Electronic address: wmanucha@yahoo.com.ar. |
| المصدر: | Life sciences [Life Sci] 2020 Aug 01; Vol. 254, pp. 117808. Date of Electronic Publication: 2020 May 15. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2008->: Amsterdam : Elsevier Original Publication: Oxford; Elmsford, N. Y. [etc.] Pergamon Press. |
| مواضيع طبية MeSH: | Coronavirus Infections/*drug therapy , Lung/*virology , Melatonin/*therapeutic use , Pneumonia, Viral/*drug therapy , Vitamin D/*therapeutic use, Antioxidants ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/pathology ; Humans ; Inflammation ; Pandemics ; Pneumonia, Viral/pathology ; Renin-Angiotensin System ; SARS-CoV-2 ; COVID-19 Drug Treatment |
| مستخلص: | COVID-19 pandemic has a high mortality rate and is affecting practically the entire world population. The leading cause of death is severe acute respiratory syndrome as a consequence of exacerbated inflammatory response accompanied by uncontrolled oxidative stress as well as the inflammatory reaction at the lung level. Until now, there is not a specific and definitive treatment for this pathology that worries the world population, especially the older adults who constitute the main risk group. In this context, it results in a particular interest in the evaluation of the efficacy of existing pharmacological agents that may be used for overcoming or attenuating the severity of this pulmonary complication that has ended the lives of many people worldwide. Vitamin D and melatonin could be good options for achieving this aim, taking into account that they have many shared underlying mechanisms that are able to modulate and control the immune adequately and oxidative response against COVID-19 infection, possibly even through a synergistic interaction. The renin-angiotensin system exaltation with consequent inflammatory response has a leading role in the physiopathology of COVID-19 infection; and it may be down-regulated by vitamin D and melatonin in many organs. Therefore, it is also essential to analyze this potential therapeutic association and their relation with RAS as part of this new approach. Competing Interests: Declaration of competing interest The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. (Copyright © 2020 Elsevier Inc. All rights reserved.) |
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| فهرسة مساهمة: | Keywords: COVID-19; Inflammation; Melatonin; Oxidation; Renin-angiotensin system; Vitamin D |
| المشرفين على المادة: | 0 (Antioxidants) 1406-16-2 (Vitamin D) JL5DK93RCL (Melatonin) |
| تواريخ الأحداث: | Date Created: 20200519 Date Completed: 20200617 Latest Revision: 20230328 |
| رمز التحديث: | 20230328 |
| مُعرف محوري في PubMed: | PMC7227533 |
| DOI: | 10.1016/j.lfs.2020.117808 |
| PMID: | 32422305 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-0631 |
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| DOI: | 10.1016/j.lfs.2020.117808 |