دورية أكاديمية
Rubidium-82 generator yield and efficiency for PET perfusion imaging: Comparison of two clinical systems.
| العنوان: | Rubidium-82 generator yield and efficiency for PET perfusion imaging: Comparison of two clinical systems. |
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| المؤلفون: | Ahmadi A; Division of Cardiology, University of Ottawa Heart Institute, National Cardiac PET Centre, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada., Klein R; Division of Nuclear Medicine, The Ottawa Hospital, Ottawa, ON, Canada., Lewin HC; Cardiac Imaging Nuclear Associates, Los Angeles, CA, USA., Beanlands RSB; Division of Cardiology, University of Ottawa Heart Institute, National Cardiac PET Centre, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada., deKemp RA; Division of Cardiology, University of Ottawa Heart Institute, National Cardiac PET Centre, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada. RAdeKemp@ottawaheart.ca. |
| المصدر: | Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology [J Nucl Cardiol] 2020 Oct; Vol. 27 (5), pp. 1728-1738. Date of Electronic Publication: 2020 May 20. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 9423534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6551 (Electronic) Linking ISSN: 10713581 NLM ISO Abbreviation: J Nucl Cardiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York : Springer Original Publication: St. Louis, MO : Mosby-Year Book, Inc., c1994- |
| مواضيع طبية MeSH: | Rubidium Radioisotopes* , Strontium Radioisotopes*, Heart Diseases/*diagnostic imaging , Myocardial Perfusion Imaging/*instrumentation , Positron-Emission Tomography/*instrumentation , Radionuclide Generators/*instrumentation, Humans ; Quality Assurance, Health Care ; Retrospective Studies |
| مستخلص: | Introduction: Strontium-82/Rubidium-82 ( 82 Sr/ 82 Rb) generators are used widely for positron emission tomography (PET) imaging of myocardial perfusion. In this study, the 82 Rb isotope yield and production efficiency of two FDA-approved 82 Sr/ 82 Rb generators were compared. Methods: N = 515 sequential daily quality assurance (QA) reports from 9 CardioGen-82 ® and 9 RUBY-FILL ® generators were reviewed over a period of 2 years. A series of test elutions was performed at different flow-rates on the RUBY-FILL ® system to determine an empirical correction-factor used to convert CardioGen-82 ® daily QA values of 82 Rb activity (dose-calibrator 'maximum' of 50 mL elution at 50 mL·min -1 ) to RUBY-FILL ® equivalent values (integrated 'total' of 35 mL elution at 20 mL·min -1 ). The generator yield ( 82 Rb) and production efficiency ( 82 Rb yield/ 82 Sr parent activity) were measured and compared after this conversion to a common scale. Results: At the start of clinical use, the system reported 82 Rb activity from daily QA was lower for CardioGen-82 ® vs RUBY-FILL ® (2.3 ± 0.2 vs 3.0 ± 0.2 GBq, P < 0.001) despite having similar 82 Sr activity. Dose-calibrator 'maximum' (CardioGen-82 ® ) values were found to under-estimate the integrated 'total' (RUBY-FILL ® ) activity by ~ 24% at 50 mL·min -1 . When these data were used to convert the CardioGen-82 values to a common measurement scale (integrated total activity) the CardioGen-82 ® efficiency remained slightly lower than the RUBY-FILL ® system on average (88 ± 4% vs 95 ± 4%, P < 0.001). The efficiency of 82 Rb production improved for both systems over the respective periods of clinical use. Conclusions: 82 Rb generator yield was significantly under-estimated using the CardioGen-82 ® vs RUBY-FILL ® daily QA procedure. When generator yield was expressed as the integrated total activity for both systems, the estimated 82 Rb production efficiency of the CardioGen-82 ® system was ~ 7% lower than RUBY-FILL ® over the full period of clinical use. |
| التعليقات: | Comment in: J Nucl Cardiol. 2020 Oct;27(5):1739-1742. (PMID: 32642920) Comment in: J Nucl Cardiol. 2020 Oct;27(5):1743. (PMID: 32895860) |
| References: | J Am Coll Cardiol. 2013 Jan 15;61(2):176-84. (PMID: 23219297) J Nucl Med. 2017 Jan;58(1):103-109. (PMID: 27539843) JACC Cardiovasc Imaging. 2009 Jul;2(7):846-54. (PMID: 19608135) J Am Coll Cardiol. 2011 Aug 9;58(7):740-8. (PMID: 21816311) J Nucl Med Technol. 2015 Jun;43(2):113-6. (PMID: 25956692) Phys Med Biol. 2007 Feb 7;52(3):659-73. (PMID: 17228112) J Cardiol. 2010 Mar;55(2):163-73. (PMID: 20206068) Nucl Med Commun. 2017 Aug;38(8):708-714. (PMID: 28703721) Cardiovasc Diagn Ther. 2017 Apr;7(2):206-218. (PMID: 28540215) J Nucl Med Technol. 2007 Dec;35(4):272-5. (PMID: 18006598) J Nucl Med. 2010 Oct;51(10):1592-9. (PMID: 20847168) Semin Nucl Med. 2014 Sep;44(5):344-57. (PMID: 25234079) J Nucl Cardiol. 2010 Aug;17(4):555-70. (PMID: 20596841) J Nucl Cardiol. 2018 Jun;25(3):929-941. (PMID: 27804067) Eur J Nucl Med Mol Imaging. 2015 Jun;42(7):1032-42. (PMID: 25820674) J Nucl Cardiol. 2019 Dec;26(6):1869-1874. (PMID: 29589206) J Nucl Med. 2014 Jan;55(1):58-64. (PMID: 24249797) Front Med (Lausanne). 2015 Sep 11;2:65. (PMID: 26442267) Int J Rad Appl Instrum A. 1987;38(3):205-11. (PMID: 3034827) Eur J Nucl Med Mol Imaging. 2015 Feb;42(2):328-54. (PMID: 25452219) J Nucl Cardiol. 2017 Aug;24(4):1395-1401. (PMID: 27184903) |
| فهرسة مساهمة: | Keywords: Myocardial perfusion imaging; daily quality assurance; positron emission tomography; rubidium-82 generator |
| المشرفين على المادة: | 0 (Rubidium Radioisotopes) 0 (Strontium Radioisotopes) 8PY97O7TON (Strontium-82) 9K730EL8KU (Rubidium-82) |
| تواريخ الأحداث: | Date Created: 20200522 Date Completed: 20211122 Latest Revision: 20240130 |
| رمز التحديث: | 20240130 |
| مُعرف محوري في PubMed: | PMC7599151 |
| DOI: | 10.1007/s12350-020-02200-6 |
| PMID: | 32436115 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1532-6551 |
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| DOI: | 10.1007/s12350-020-02200-6 |