دورية أكاديمية
Pyrrolidine dithiocarbamate reduces alloxan-induced kidney damage by decreasing nox4, inducible nitric oxide synthase, and metalloproteinase-2.
| العنوان: | Pyrrolidine dithiocarbamate reduces alloxan-induced kidney damage by decreasing nox4, inducible nitric oxide synthase, and metalloproteinase-2. |
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| المؤلفون: | Pereira BP; Departamento de Alimentos e Medicamentos, Universidade Federal de Alfenas (UNIFAL-MG), Alfenas, Minas Gerais,, Brazil., do Valle GT; Escola de Enfermagem de Ribeirão Preto (EERP), Universidade de São Paulo - USP, Sao Paulo, Brazil., Salles BCC; Departamento de Análises Clínicas, Universidade Federal de Alfenas (UNIFAL-MG), Alfenas, Minas Gerais, Brazil., Costa KCM; Departamento de Alimentos e Medicamentos, Universidade Federal de Alfenas (UNIFAL-MG), Alfenas, Minas Gerais,, Brazil., Ângelo ML; Departamento de Alimentos e Medicamentos, Universidade Federal de Alfenas (UNIFAL-MG), Alfenas, Minas Gerais,, Brazil., Torres LHL; Departamento de Alimentos e Medicamentos, Universidade Federal de Alfenas (UNIFAL-MG), Alfenas, Minas Gerais,, Brazil., Novaes RD; Departamento de Biologia Estrutural, Universidade Federal de Alfenas (UNIFAL-MG), Alfenas, Minas Gerais, Brazil., Ruginsk SG; Departamento de Ciências Fisiológicas, Universidade Federal de Alfenas (UNIFAL-MG), Alfenas, Minas Gerais, Brazil., Tirapelli CR; Escola de Enfermagem de Ribeirão Preto (EERP), Universidade de São Paulo - USP, Sao Paulo, Brazil., de Araújo Paula FB; Departamento de Análises Clínicas, Universidade Federal de Alfenas (UNIFAL-MG), Alfenas, Minas Gerais, Brazil., Ceron CS; Departamento de Alimentos e Medicamentos, Universidade Federal de Alfenas (UNIFAL-MG), Alfenas, Minas Gerais,, Brazil. carlasceron@gmail.com. |
| المصدر: | Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2020 Oct; Vol. 393 (10), pp. 1899-1910. Date of Electronic Publication: 2020 May 21. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin, New York, Springer Verlag. |
| مواضيع طبية MeSH: | Matrix Metalloproteinase 2*/metabolism, Alloxan/*toxicity , Kidney Diseases/*drug therapy , NADPH Oxidase 4/*antagonists & inhibitors , Nitric Oxide Synthase Type II/*antagonists & inhibitors , Pyrrolidines/*therapeutic use , Thiocarbamates/*therapeutic use, Animals ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Kidney Diseases/chemically induced ; Kidney Diseases/enzymology ; Male ; Matrix Metalloproteinase Inhibitors/pharmacology ; Matrix Metalloproteinase Inhibitors/therapeutic use ; NADPH Oxidase 4/metabolism ; Nitric Oxide Synthase Type II/metabolism ; Pyrrolidines/pharmacology ; Rats ; Rats, Wistar ; Thiocarbamates/pharmacology |
| مستخلص: | We examined the effect of the NFκB inhibitor pyrrolidine-1-carbodithioic acid (PDTC) on inducible nitric oxide synthase (iNOS), matrix metalloproteinase-2 (MMP-2) activity, and oxidative and inflammatory kidney damage in alloxan-induced diabetes. Two weeks after diabetes induction (alloxan-130 mg/kg), control and diabetic rats received PDTC (100 mg/kg) or vehicle for 8 weeks. Body weight, glycemia, urea, and creatinine were measured. Kidney changes were measured in hematoxylin/eosin sections and ED1 by immunohistochemistry. Kidney thiobarbituric acid reactive substances (TBARS), superoxide anion (O2-), and nitrate/nitrite (NOx) levels, and catalase and superoxide dismutase (SOD) activities were analyzed. Also, kidney nox4 and iNOS expression, and NFkB nuclear translocation were measured by western blot, and MMP-2 by zymography. Glycemia and urea increased in alloxan rats, which were not modified by PDTC treatment. However, PDTC attenuated kidney structural alterations and macrophage infiltration in diabetic rats. While diabetes increased both TBARS and O |
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| معلومات مُعتمدة: | 406177/2016-3 International Conselho Nacional de Desenvolvimento Científico e Tecnológico; APQ-01239-16 and PPM-00383-18 International Fundação de Amparo à Pesquisa do Estado de Minas Gerais; 2015/22046-8 International Fundação de Amparo à Pesquisa do Estado de São Paulo |
| فهرسة مساهمة: | Keywords: Alloxan-induced diabetes; Inducible nitric oxide synthase; Kidney damage; Matrix metalloproteinases; Oxidative stress; Pyrrolidine dithiocarbamate |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Matrix Metalloproteinase Inhibitors) 0 (Pyrrolidines) 0 (Thiocarbamates) 25769-03-3 (pyrrolidine dithiocarbamic acid) 6SW5YHA5NG (Alloxan) EC 1.14.13.39 (Nitric Oxide Synthase Type II) EC 1.14.13.39 (Nos2 protein, rat) EC 1.6.3.- (NADPH Oxidase 4) EC 1.6.3.- (Nox4 protein, rat) EC 3.4.24.24 (Matrix Metalloproteinase 2) EC 3.4.24.24 (Mmp2 protein, rat) |
| تواريخ الأحداث: | Date Created: 20200523 Date Completed: 20210811 Latest Revision: 20230602 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1007/s00210-020-01906-1 |
| PMID: | 32440769 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1432-1912 |
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| DOI: | 10.1007/s00210-020-01906-1 |