دورية أكاديمية
SIRT1-NOX4 signaling axis regulates cancer cachexia.
| العنوان: | SIRT1-NOX4 signaling axis regulates cancer cachexia. |
|---|---|
| المؤلفون: | Dasgupta A; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE., Shukla SK; The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE., Vernucci E; The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE., King RJ; The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE., Abrego J; The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE., Mulder SE; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE., Mullen NJ; The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE., Graves G; The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE., Buettner K; The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE., Thakur R; The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE., Murthy D; The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE., Attri KS; The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE., Wang D; The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE., Chaika NV; The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE., Pacheco CG; The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE., Rai I; The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE., Engle DD; Cancer Center at Cold Spring Harbor Laboratory, Cold Spring Harbor, NY., Grandgenett PM; The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE., Punsoni M; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE., Reames BN; Department of Surgery, University of Nebraska Medical Center, Omaha, NE., Teoh-Fitzgerald M; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE., Oberley-Deegan R; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE., Yu F; Department of Biostatistics, University of Nebraska Medical Center, Omaha, NE., Klute KA; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE., Hollingsworth MA; The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE., Zimmerman MC; Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE., Mehla K; The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE., Sadoshima J; Department of Cell Biology and Molecular Medicine, New Jersey Medical School, Rutgers University, Newark, NJ., Tuveson DA; Cancer Center at Cold Spring Harbor Laboratory, Cold Spring Harbor, NY., Singh PK; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE.; The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE.; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE. |
| المصدر: | The Journal of experimental medicine [J Exp Med] 2020 Jul 06; Vol. 217 (7). |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Rockefeller University Press |
| مواضيع طبية MeSH: | Signal Transduction*/drug effects, Cachexia/*complications , Cachexia/*metabolism , NADPH Oxidase 4/*metabolism , Neoplasms/*complications , Neoplasms/*metabolism , Sirtuin 1/*metabolism, Adipose Tissue/pathology ; Animals ; Cell Line ; Cell Line, Tumor ; Disease Models, Animal ; Disease Progression ; Forkhead Transcription Factors/metabolism ; HEK293 Cells ; Humans ; Metabolome/drug effects ; Mice ; Muscle Fibers, Skeletal/drug effects ; Muscle Fibers, Skeletal/metabolism ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/pathology ; Muscular Atrophy/metabolism ; Muscular Atrophy/pathology ; NF-kappa B/metabolism ; Oxidation-Reduction ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; Protein Stability/drug effects ; Reactive Oxygen Species/metabolism ; Resveratrol/pharmacology ; Wasting Syndrome/pathology |
| مستخلص: | Approximately one third of cancer patients die due to complexities related to cachexia. However, the mechanisms of cachexia and the potential therapeutic interventions remain poorly studied. We observed a significant positive correlation between SIRT1 expression and muscle fiber cross-sectional area in pancreatic cancer patients. Rescuing Sirt1 expression by exogenous expression or pharmacological agents reverted cancer cell-induced myotube wasting in culture conditions and mouse models. RNA-seq and follow-up analyses showed cancer cell-mediated SIRT1 loss induced NF-κB signaling in cachectic muscles that enhanced the expression of FOXO transcription factors and NADPH oxidase 4 (Nox4), a key regulator of reactive oxygen species production. Additionally, we observed a negative correlation between NOX4 expression and skeletal muscle fiber cross-sectional area in pancreatic cancer patients. Knocking out Nox4 in skeletal muscles or pharmacological blockade of Nox4 activity abrogated tumor-induced cachexia in mice. Thus, we conclude that targeting the Sirt1-Nox4 axis in muscles is an effective therapeutic intervention for mitigating pancreatic cancer-induced cachexia. Competing Interests: Disclosures: D.A. Tuveson reported "other" from Surface Oncology, Leap Therapeutics, and Cygnal Therapeutics; grants from ONO and Fibrogen; personal fees from Chugai and Merck outside the submitted work; SAB, stock from Surface Oncology, Leap Therapeutics, and Cygnal Therapeutics; sponsored research from ONO and Fibrogen; and honoraria from Chugai and Merck. No other disclosures were reported. (© 2020 Dasgupta et al.) |
| References: | Mol Cell. 2003 Jul;12(1):51-62. (PMID: 12887892) Nutr Cancer. 2017 Oct;69(7):1019-1027. (PMID: 28937798) Chin Med J (Engl). 2011 Jun;124(11):1695-9. (PMID: 21740780) J Cachexia Sarcopenia Muscle. 2017 Oct;8(5):824-838. (PMID: 28730707) Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14440-5. (PMID: 11717410) Dev Cell. 2008 May;14(5):661-73. (PMID: 18477450) NPJ Aging Mech Dis. 2016 Aug 18;2:16017. (PMID: 28721271) EMBO J. 1996 Apr 15;15(8):1753-65. (PMID: 8617220) Curr Opin Clin Nutr Metab Care. 2010 May;13(3):236-42. (PMID: 20098320) Am J Physiol Heart Circ Physiol. 2013 Jul 1;305(1):H19-28. (PMID: 23624625) Aging (Albany NY). 2011 Apr;3(4):430-7. (PMID: 21483036) Lancet Oncol. 2011 May;12(5):489-95. (PMID: 21296615) Front Physiol. 2018 Apr 05;9:340. (PMID: 29674975) Nature. 2003 Sep 11;425(6954):191-6. (PMID: 12939617) Cell. 2016 Jun 2;165(6):1401-1415. (PMID: 27180906) Cell. 2004 Oct 15;119(2):285-98. (PMID: 15479644) EMBO J. 2002 Dec 2;21(23):6539-48. (PMID: 12456660) Free Radic Biol Med. 2012 Jul 15;53(2):289-96. (PMID: 22618020) Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13787-92. (PMID: 22869720) Cell. 2006 Dec 15;127(6):1109-22. (PMID: 17112576) Br J Cancer. 2003 Sep 15;89(6):1116-22. (PMID: 12966435) EMBO J. 2004 Jun 16;23(12):2369-80. (PMID: 15152190) Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15565-70. (PMID: 20713697) Cancer. 2004 Dec 15;101(12):2727-36. (PMID: 15526319) J Biol Chem. 2009 Aug 14;284(33):21872-80. (PMID: 19553684) Ann Rheum Dis. 2006 Nov;65 Suppl 3:iii75-82. (PMID: 17038479) Cancer Lett. 2017 Aug 1;400:37-46. (PMID: 28455244) J Cell Mol Med. 2008 Dec;12(6A):2350-61. (PMID: 18266981) Redox Biol. 2013 Oct 25;1:599-607. (PMID: 24363995) Oncotarget. 2015 Dec 1;6(38):41146-61. (PMID: 26510913) Aging Cell. 2015 Aug;14(4):511-23. (PMID: 25866088) Ann N Y Acad Sci. 2015 Aug;1348(1):10-9. (PMID: 26284849) Physiol Rep. 2014 Jul 04;2(7):. (PMID: 24997067) Cell. 2005 Nov 4;123(3):437-48. (PMID: 16269335) PLoS One. 2010 Dec 20;5(12):e15354. (PMID: 21187957) Cancer Lett. 2002 Jun 6;180(1):69-74. (PMID: 11911972) J Cancer Res Clin Oncol. 2014 May;140(5):749-55. (PMID: 24604347) Genet Mol Res. 2015 Oct 16;14(4):12386-93. (PMID: 26505388) Nutr Cancer. 2011;63(5):749-62. (PMID: 21660860) Dis Model Mech. 2010 May-Jun;3(5-6):298-303. (PMID: 20354108) Nature. 2000 Feb 17;403(6771):795-800. (PMID: 10693811) Am J Physiol Cell Physiol. 2012 Jul 15;303(2):C213-23. (PMID: 22572850) Skelet Muscle. 2012 May 07;2(1):8. (PMID: 22564549) J Gastrointest Surg. 2008 Jul;12(7):1193-201. (PMID: 18347879) Genes Cancer. 2011 Jun;2(6):648-62. (PMID: 21941620) Int J Mol Med. 2014 May;33(5):1161-8. (PMID: 24584901) Biochem Biophys Res Commun. 2010 Jun 11;396(4):901-7. (PMID: 20457132) J Hepatol. 2008 Dec;49(6):965-76. (PMID: 18845355) Oxid Med Cell Longev. 2018 Mar 28;2018:2063179. (PMID: 29785242) J Biol Chem. 1999 Jan 8;274(2):787-94. (PMID: 9873017) Oxid Med Cell Longev. 2017;2017:7543973. (PMID: 28546854) Int J Mol Sci. 2013 Feb 11;14(2):3834-59. (PMID: 23434668) Eur J Cell Biol. 2009 Jan;88(1):35-44. (PMID: 18922599) Am J Med. 1980 Oct;69(4):491-7. (PMID: 7424938) Cell Metab. 2007 Dec;6(6):472-83. (PMID: 18054316) Nat Commun. 2017 Feb 24;8:14437. (PMID: 28232723) Ann Oncol. 2014 Aug;25(8):1492-9. (PMID: 24569913) Nat Rev Dis Primers. 2018 Jan 18;4:17105. (PMID: 29345251) Cell Metab. 2007 Dec;6(6):458-71. (PMID: 18054315) Cancer Cell. 2017 Jul 10;32(1):71-87.e7. (PMID: 28697344) Eur J Pharmacol. 2015 Jun 15;757:59-67. (PMID: 25843411) Cell. 2004 Apr 30;117(3):399-412. (PMID: 15109499) PLoS One. 2015 Jun 29;10(6):e0131344. (PMID: 26121130) J Biol Chem. 2013 Oct 18;288(42):30515-26. (PMID: 24003218) Redox Biol. 2015 Dec;6:51-72. (PMID: 26184557) Science. 2001 Nov 23;294(5547):1704-8. (PMID: 11679633) Cancer Res. 2010 Feb 1;70(3):859-62. (PMID: 20086171) Anticancer Res. 2013 Oct;33(10):4431-8. (PMID: 24123012) Curr Biol. 2015 Jun 29;25(13):R569-83. (PMID: 26126285) Cell Signal. 2013 Oct;25(10):1939-48. (PMID: 23770291) Nature. 2001 Mar 8;410(6825):227-30. (PMID: 11242085) Mech Ageing Dev. 2018 Mar;170:37-44. (PMID: 28851603) Biomed Pharmacother. 2016 Dec;84:1979-1985. (PMID: 27847206) Cell Cycle. 2014;13(23):3759-67. (PMID: 25483084) EMBO J. 2005 Mar 9;24(5):1021-32. (PMID: 15692560) Biochem Soc Trans. 2007 Nov;35(Pt 5):1156-60. (PMID: 17956300) Front Cell Neurosci. 2012 Dec 31;6:63. (PMID: 23293585) Cell Rep. 2015 Mar 17;10(10):1665-1673. (PMID: 25772354) Am J Clin Nutr. 2006 Jun;83(6):1345-50. (PMID: 16762946) Science. 1997 Jan 10;275(5297):218-20. (PMID: 8985016) Int J Mol Sci. 2019 Jul 09;20(13):. (PMID: 31324056) BMC Cancer. 2009 Jul 28;9:255. (PMID: 19635171) Biochem Biophys Res Commun. 2003 Feb 21;301(4):1038-44. (PMID: 12589817) Cancer Metab. 2014 Sep 01;2:18. (PMID: 25228990) FASEB J. 2012 Mar;26(3):987-1000. (PMID: 22102632) |
| معلومات مُعتمدة: | R01 CA216853 United States CA NCI NIH HHS; R01 CA188134 United States CA NCI NIH HHS; R01 HL091469 United States HL NHLBI NIH HHS; R01 CA190092 United States CA NCI NIH HHS; P30 CA036727 United States CA NCI NIH HHS; R01 CA163649 United States CA NCI NIH HHS; P30 CA045508 United States CA NCI NIH HHS; T32 CA009476 United States CA NCI NIH HHS; T32 CA148056 United States CA NCI NIH HHS; P01 CA217798 United States CA NCI NIH HHS; P50 CA127297 United States CA NCI NIH HHS; R50 CA211462 United States CA NCI NIH HHS; R01 CA210439 United States CA NCI NIH HHS; U01 CA210240 United States CA NCI NIH HHS; P30 GM103335 United States GM NIGMS NIH HHS; R01 HL112330 United States HL NHLBI NIH HHS |
| المشرفين على المادة: | 0 (Forkhead Transcription Factors) 0 (NF-kappa B) 0 (Reactive Oxygen Species) EC 1.6.3.- (NADPH Oxidase 4) EC 3.5.1.- (Sirtuin 1) Q369O8926L (Resveratrol) |
| تواريخ الأحداث: | Date Created: 20200523 Date Completed: 20210216 Latest Revision: 20210502 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC7336299 |
| DOI: | 10.1084/jem.20190745 |
| PMID: | 32441762 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1540-9538 |
|---|---|
| DOI: | 10.1084/jem.20190745 |