دورية أكاديمية
Impaired Hippocampal-Cortical Interactions during Sleep in a Mouse Model of Alzheimer's Disease.
العنوان: | Impaired Hippocampal-Cortical Interactions during Sleep in a Mouse Model of Alzheimer's Disease. |
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المؤلفون: | Benthem SD; Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL 32306, USA. Electronic address: benthem@psy.fsu.edu., Skelin I; Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697, USA., Moseley SC; Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL 32306, USA., Stimmell AC; Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL 32306, USA., Dixon JR; Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL 32306, USA., Melilli AS; Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL 32306, USA., Molina L; Department of Neuroscience, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada., McNaughton BL; Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697, USA; Department of Neuroscience, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada., Wilber AA; Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL 32306, USA. Electronic address: awilber@fsu.edu. |
المصدر: | Current biology : CB [Curr Biol] 2020 Jul 06; Vol. 30 (13), pp. 2588-2601.e5. Date of Electronic Publication: 2020 May 28. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
اللغة: | English |
بيانات الدورية: | Publisher: Cell Press Country of Publication: England NLM ID: 9107782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0445 (Electronic) Linking ISSN: 09609822 NLM ISO Abbreviation: Curr Biol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Cambridge, MA : Cell Press Original Publication: London, UK : Current Biology Ltd., c1991- |
مواضيع طبية MeSH: | Memory Consolidation* , Sleep*, Alzheimer Disease/*physiopathology , Hippocampus/*physiopathology , Memory Disorders/*physiopathology , Neocortex/*physiopathology, Animals ; Disease Models, Animal ; Female ; Mice ; Mice, Transgenic ; Spatial Memory |
مستخلص: | Spatial learning is impaired in humans with preclinical Alzheimer's disease (AD). We reported similar impairments in 3xTg-AD mice learning a spatial reorientation task. Memory reactivation during sleep is critical for learning-related plasticity, and memory consolidation is correlated with hippocampal sharp wave ripple (SWR) density, cortical delta waves (DWs), cortical spindles, and the temporal coupling of these events-postulated as physiological substrates for memory consolidation. Further, hippocampal-cortical discoordination is prevalent in individuals with AD. Thus, we hypothesized that impaired memory consolidation mechanisms in hippocampal-cortical networks could account for spatial memory deficits. We assessed sleep architecture, SWR-DW dynamics, and memory reactivation in a mouse model of tauopathy and amyloidosis implanted with a recording array targeting isocortex and hippocampus. Mice underwent daily recording sessions of rest-task-rest while learning the spatial reorientation task. We assessed memory reactivation by matching activity patterns from the approach to the unmarked reward zone to patterns during slow-wave sleep (SWS). AD mice had more SWS, but reduced SWR density. The increased SWS compensated for reduced SWR density so there was no reduction in SWR number. In control mice, spindles were phase-coupled with DWs, and hippocampal SWR-cortical DW coupling was strengthened in post-task sleep and was correlated with performance on the spatial reorientation task the following day. However, in AD mice, SWR-DW and spindle-DW coupling were impaired. Thus, reduced SWR-DW coupling may cause impaired learning in AD, and spindle-DW coupling during short rest-task-rest sessions may serve as a biomarker for early AD-related changes in these brain dynamics. Competing Interests: Declaration of Interests The authors declare no competing interests. (Copyright © 2020 Elsevier Inc. All rights reserved.) |
التعليقات: | Erratum in: Curr Biol. 2024 Mar 28;:. (PMID: 38552626) |
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معلومات مُعتمدة: | K99 AG049090 United States AG NIA NIH HHS; R00 AG049090 United States AG NIA NIH HHS; PJT 156040 Canada CIHR |
فهرسة مساهمة: | Keywords: Alzheimer's disease; hippocampal-cortical dynamics; hippocampus; memory reactivation; memory replay; parietal cortex; sharp wave ripples; sleep; spatial memory; spatial orientation |
تواريخ الأحداث: | Date Created: 20200530 Date Completed: 20210809 Latest Revision: 20240329 |
رمز التحديث: | 20240330 |
مُعرف محوري في PubMed: | PMC7356567 |
DOI: | 10.1016/j.cub.2020.04.087 |
PMID: | 32470367 |
قاعدة البيانات: | MEDLINE |
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