دورية أكاديمية
Cardiac Fibrosis Is Associated With Decreased Circulating Levels of Full-Length CILP in Heart Failure.
العنوان: | Cardiac Fibrosis Is Associated With Decreased Circulating Levels of Full-Length CILP in Heart Failure. |
---|---|
المؤلفون: | Park S; Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, California.; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles (UCLA), Los Angeles, California.; Molecular, Cellular, and Integrative Physiology Graduate Program, University of California, Los Angeles (UCLA), Los Angeles, California., Ranjbarvaziri S; Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, California.; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles (UCLA), Los Angeles, California.; Molecular, Cellular, and Integrative Physiology Graduate Program, University of California, Los Angeles (UCLA), Los Angeles, California., Zhao P; Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, California., Ardehali R; Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, California.; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles (UCLA), Los Angeles, California.; Molecular, Cellular, and Integrative Physiology Graduate Program, University of California, Los Angeles (UCLA), Los Angeles, California.; Molecular Biology Institute, UCLA, Los Angeles, California. |
المصدر: | JACC. Basic to translational science [JACC Basic Transl Sci] 2020 Apr 15; Vol. 5 (5), pp. 432-443. Date of Electronic Publication: 2020 Apr 15 (Print Publication: 2020). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier on behalf of the American College of Cardiology Foundation Country of Publication: United States NLM ID: 101677259 Publication Model: eCollection Cited Medium: Internet ISSN: 2452-302X (Electronic) Linking ISSN: 2452302X NLM ISO Abbreviation: JACC Basic Transl Sci Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: [New York] : Elsevier on behalf of the American College of Cardiology Foundation, [2016]- |
مستخلص: | Cardiac fibrosis is a pathological process associated with various forms of heart failure. This study identified latent transforming growth factor-β binding protein 2, cartilage oligomeric matrix protein, and cartilage intermediate layer protein 1 as potential biomarkers for cardiac fibrosis. All 3 encoded proteins showed increased expression in fibroblasts after transforming growth factor-β stimulation in vitro and localized specifically to fibrotic regions in vivo. Of the 3, only the full-length cartilage intermediate layer protein 1 showed a significant decrease in circulating levels in patients with heart failure compared with healthy volunteers. Further studies on these 3 proteins will lead to a better understanding of their biomarker potential for cardiac fibrosis. (© 2020 The Authors.) |
التعليقات: | Comment in: JACC Basic Transl Sci. 2020 May 25;5(5):444-446. (PMID: 32479564) |
References: | Nat Rev Nephrol. 2016 Jun;12(6):325-38. (PMID: 27108839) Cell Mol Life Sci. 2014 Feb;71(4):549-74. (PMID: 23649149) Genome Biol. 2014;15(12):550. (PMID: 25516281) Circ Res. 2014 Sep 12;115(7):625-35. (PMID: 25037571) J Mol Cell Cardiol. 2018 Mar;116:135-144. (PMID: 29438665) Matrix Biol. 2007 May;26(4):213-23. (PMID: 17293099) J Biol Chem. 1998 Sep 4;273(36):23463-8. (PMID: 9722583) Fibrogenesis Tissue Repair. 2012 Sep 03;5(1):15. (PMID: 22943504) J Biol Chem. 1998 Aug 7;273(32):20397-403. (PMID: 9685393) Basic Res Cardiol. 2013 Sep;108(5):374. (PMID: 23917519) J Mol Cell Cardiol. 2011 Oct;51(4):600-6. (PMID: 21059352) Circulation. 2014 Mar 4;129(9):1009-21. (PMID: 24429688) PLoS One. 2013 Dec 20;8(12):e83120. (PMID: 24376648) Circulation. 2018 Sep 18;138(12):1224-1235. (PMID: 29950403) Dev Dyn. 2004 Aug;230(4):787-94. (PMID: 15254913) Am J Respir Crit Care Med. 2012 Sep 15;186(6):525-35. (PMID: 22700861) Am J Pathol. 1991 Jul;139(1):207-16. (PMID: 1853934) Circ Res. 2016 Mar 18;118(6):1021-40. (PMID: 26987915) Cell Immunol. 2018 Mar;325:1-13. (PMID: 29329637) Nat Genet. 2005 Jun;37(6):607-12. (PMID: 15864306) Circ Heart Fail. 2009 Mar;2(2):138-44. (PMID: 19808329) J Hepatol. 2016 Nov;65(5):963-971. (PMID: 27318326) J Biol Chem. 1992 Mar 25;267(9):6132-6. (PMID: 1556121) J Biol Chem. 2011 Oct 28;286(43):37758-67. (PMID: 21880736) Transl Res. 2019 Jul;209:121-137. (PMID: 30930180) Matrix Biol. 2014 Jul;37:102-11. (PMID: 24997222) Mol Cell Proteomics. 2012 Jan;11(1):M111.010504. (PMID: 21947364) Circ Heart Fail. 2011 Jan;4(1):5-7. (PMID: 21245455) J Clin Invest. 2018 Jan 2;128(1):26-35. (PMID: 29293096) Rheumatology (Oxford). 2012 May;51(5):915-20. (PMID: 22253028) Circ Cardiovasc Imaging. 2012 Jan;5(1):9-11. (PMID: 22253334) Immunology. 2006 May;118(1):10-24. (PMID: 16630019) Eur J Intern Med. 2017 Mar;38:83-88. (PMID: 28100410) Sci Rep. 2017 Nov 22;7(1):16042. (PMID: 29167509) Am J Cardiol. 1999 Feb 1;83(3):376-82. (PMID: 10072227) Circulation. 2012 Feb 14;125(6):789-802. (PMID: 22261194) Cardiovasc Ther. 2012 Feb;30(1):e30-40. (PMID: 21883991) J Cardiovasc Transl Res. 2012 Dec;5(6):739-48. (PMID: 22878976) J Cell Physiol. 1997 Jan;170(1):69-80. (PMID: 9012786) Circ Res. 2009 Nov 6;105(10):934-47. (PMID: 19893021) J Biol Chem. 1998 Sep 4;273(36):23469-75. (PMID: 9722584) Matrix Biol. 2015 Sep;47:44-53. (PMID: 25960419) |
معلومات مُعتمدة: | DP2 HL127728 United States HL NHLBI NIH HHS; T32 HL069766 United States HL NHLBI NIH HHS |
فهرسة مساهمة: | Keywords: CFB, cardiac fibroblast; CILP, cartilage intermediate layer protein 1; COMP, cartilage oligomeric matrix protein; ECM, extracellular matrix; ELISA, enzyme-linked immunosorbent assay; Ltbp2, latent transforming growth factor-β binding protein 2; PCR, polymerase chain reaction; RNA, ribonucleic acid; TAC, transverse aortic constriction; TGF, transforming growth factor; biomarker; cardiac fibrosis; extracellular matrix protein; heart failure |
تواريخ الأحداث: | Date Created: 20200602 Latest Revision: 20240426 |
رمز التحديث: | 20240426 |
مُعرف محوري في PubMed: | PMC7251193 |
DOI: | 10.1016/j.jacbts.2020.01.016 |
PMID: | 32478206 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2452-302X |
---|---|
DOI: | 10.1016/j.jacbts.2020.01.016 |