دورية أكاديمية
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Genetic and antigenic characterization of influenza A/H5N1 viruses isolated from patients in Indonesia, 2008-2015.

التفاصيل البيبلوغرافية
العنوان: Genetic and antigenic characterization of influenza A/H5N1 viruses isolated from patients in Indonesia, 2008-2015.
المؤلفون: Pawestri HA; National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia., Nugraha AA; National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia., Han AX; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Pratiwi E; National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia., Parker E; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Department of Veterinary Medicine, University of Cambridge, Cambridge, UK., Richard M; Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands., van der Vliet S; Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands., Fouchier RAM; Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands., Muljono DH; Eijkman Institute for Molecular Biology, Jakarta, Indonesia., de Jong MD; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Setiawaty V; National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia. vilitbang@yahoo.com., Eggink D; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. w.d.eggink@amsterdamumc.nl.
المصدر: Virus genes [Virus Genes] 2020 Aug; Vol. 56 (4), pp. 417-429. Date of Electronic Publication: 2020 Jun 01.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Kluwer Academic Country of Publication: United States NLM ID: 8803967 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1572-994X (Electronic) Linking ISSN: 09208569 NLM ISO Abbreviation: Virus Genes Subsets: MEDLINE
أسماء مطبوعة: Publication: Boston Ma : Kluwer Academic
Original Publication: Boston, USA : M. Nijhoff, 1987-
مواضيع طبية MeSH: Hemagglutinin Glycoproteins, Influenza Virus/*immunology , Influenza A Virus, H5N1 Subtype/*immunology , Influenza in Birds/*immunology , Influenza, Human/*immunology, Animals ; Antigens, Viral/genetics ; Antigens, Viral/immunology ; Birds/virology ; Hemagglutinin Glycoproteins, Influenza Virus/genetics ; Humans ; Influenza A Virus, H5N1 Subtype/genetics ; Influenza A Virus, H5N1 Subtype/pathogenicity ; Influenza in Birds/genetics ; Influenza in Birds/virology ; Influenza, Human/genetics ; Influenza, Human/virology ; Phylogeny ; Poultry Diseases/immunology ; Poultry Diseases/virology
مستخلص: Since the initial detection in 2003, Indonesia has reported 200 human cases of highly pathogenic avian influenza H5N1 (HPAI H5N1), associated with an exceptionally high case fatality rate (84%) compared to other geographical regions affected by other genetic clades of the virus. However, there is limited information on the genetic diversity of HPAI H5N1 viruses, especially those isolated from humans in Indonesia. In this study, the genetic and antigenic characteristics of 35 HPAI H5N1 viruses isolated from humans were analyzed. Full genome sequences were analyzed for the presence of substitutions in the receptor binding site, and polymerase complex, as markers for virulence or human adaptation, as well as antiviral drug resistance substitutions. Only a few substitutions associated with human adaptation were observed, a remarkably low prevalence of the human adaptive substitution PB2-E627K, which is common during human infection with other H5N1 clades and a known virulence marker for avian influenza viruses during human infections. In addition, the antigenic profile of these Indonesian HPAI H5N1 viruses was determined using serological analysis and antigenic cartography. Antigenic characterization showed two distinct antigenic clusters, as observed previously for avian isolates. These two antigenic clusters were not clearly associated with time of virus isolation. This study provides better insight in genetic diversity of H5N1 viruses during human infection and the presence of human adaptive markers. These findings highlight the importance of evaluating virus genetics for HPAI H5N1 viruses to estimate the risk to human health and the need for increased efforts to monitor the evolution of H5N1 viruses across Indonesia.
References: Sci Rep. 2018 Aug 30;8(1):13066. (PMID: 30166556)
Vaccine. 2011 Nov 21;29(50):9368-75. (PMID: 22001877)
PLoS Pathog. 2010 Nov 24;6(11):e1001211. (PMID: 21124818)
J Virol. 1993 Apr;67(4):1761-4. (PMID: 8445709)
Arch Virol. 2001 Dec;146(12):2275-89. (PMID: 11811679)
N Engl J Med. 2005 Sep 29;353(13):1374-85. (PMID: 16192482)
Curr Protoc Bioinformatics. 2015 Sep 03;51:6.14.1-6.14.14. (PMID: 26334924)
Science. 2001 Sep 7;293(5536):1840-2. (PMID: 11546875)
Arch Virol. 2015 Feb;160(2):409-15. (PMID: 25504159)
Curr Top Microbiol Immunol. 2014;385:119-36. (PMID: 25085014)
Virus Genes. 2019 Dec;55(6):739-768. (PMID: 31428925)
PLoS One. 2014 Apr 17;9(4):e95539. (PMID: 24743258)
Zoonoses Public Health. 2012 Sep;59 Suppl 2:32-42. (PMID: 22958248)
Virology. 2009 Jul 20;390(1):13-21. (PMID: 19464724)
J Virol. 2009 Apr;83(8):3568-80. (PMID: 19193808)
J Virol. 2016 Jan 20;90(7):3794-9. (PMID: 26792744)
J Exp Med. 1943 Nov 1;78(5):407-23. (PMID: 19871338)
mBio. 2014 Jun 10;5(3):e01070-14. (PMID: 24917596)
Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4381-6. (PMID: 18334632)
Influenza Other Respir Viruses. 2012 Jan;6(1):1-5. (PMID: 22035148)
Nat Med. 2001 Dec;7(12):1306-12. (PMID: 11726970)
J Virol. 2018 Apr 27;92(10):. (PMID: 29491160)
PLoS One. 2018 Jan 10;13(1):e0190947. (PMID: 29320563)
Science. 2006 Apr 21;312(5772):404-10. (PMID: 16543414)
Virol J. 2011 Sep 07;8:425. (PMID: 21896207)
Science. 2004 Jul 16;305(5682):371-6. (PMID: 15218094)
Nat Rev Microbiol. 2019 Jan;17(2):67-81. (PMID: 30487536)
Avian Dis. 2007 Mar;51(1 Suppl):161-6. (PMID: 17494548)
Clin Infect Dis. 2020 Mar 3;70(6):1139-1146. (PMID: 31321436)
J Virol. 2006 Aug;80(16):7976-83. (PMID: 16873254)
Influenza Other Respir Viruses. 2014 May;8(3):384-8. (PMID: 24483237)
Sci Rep. 2015 Aug 26;5:13493. (PMID: 26306544)
Science. 2013 Nov 22;342(6161):976-9. (PMID: 24264991)
Lancet Infect Dis. 2016 Jul;16(7):e108-e118. (PMID: 27211899)
Emerg Infect Dis. 2014 Apr;20(4):671-4. (PMID: 24656213)
J Virol. 2013 Jul;87(13):7200-9. (PMID: 23616660)
Emerg Infect Dis. 2007 May;13(5):713-8. (PMID: 17553249)
J Virol. 2009 May;83(10):5278-81. (PMID: 19264775)
Nature. 2012 May 02;486(7403):420-8. (PMID: 22722205)
Euro Surveill. 2017 Mar 30;22(13):. (PMID: 28382917)
Nat Med. 2006 Oct;12(10):1203-7. (PMID: 16964257)
J Virol. 2011 Jan;85(2):652-62. (PMID: 21084483)
Science. 2012 Jun 22;336(6088):1534-41. (PMID: 22723413)
Rev Med Virol. 2015 Nov;25(6):406-30. (PMID: 26467906)
Influenza Other Respir Viruses. 2015 Sep;9(5):271-6. (PMID: 25966311)
Mol Biol Evol. 2019 Jul 1;36(7):1580-1595. (PMID: 30854550)
Biosci Rep. 2019 Jan 8;39(1):. (PMID: 30552137)
J Virol. 2013 Sep;87(18):9983-96. (PMID: 23843645)
J Mol Biol. 2008 Sep 19;381(5):1382-94. (PMID: 18672252)
Emerg Microbes Infect. 2019;8(1):262-271. (PMID: 30866780)
PLoS Pathog. 2010 Sep 16;6(9):e1001106. (PMID: 20862325)
Cell. 2014 Apr 10;157(2):329-339. (PMID: 24725402)
J Virol. 2012 Mar;86(5):2706-14. (PMID: 22205751)
Bioinformatics. 2005 Feb 15;21(4):456-63. (PMID: 15608047)
Virus Res. 2013 Dec 5;178(1):99-113. (PMID: 23619279)
Emerg Microbes Infect. 2014 Feb;3(2):e9. (PMID: 26038511)
J Virol. 2015 Apr;89(7):3746-62. (PMID: 25609805)
Virology (Auckl). 2013 Aug 19;4:27-34. (PMID: 25512692)
Euro Surveill. 2015;20(45):. (PMID: 26608955)
Int J Infect Dis. 2010 Sep;14(9):e800-5. (PMID: 20637674)
Front Microbiol. 2019 Jan 29;10:39. (PMID: 30761095)
معلومات مُعتمدة: HHSN272201400008C United States AI NIAID NIH HHS; Rersearch Grant European Society of Clinical Microbiology and Infectious Diseases; Incoming Fellowship H2020 Marie Skłodowska-Curie Actions
فهرسة مساهمة: Keywords: Adaptation; Antigenicity; H5N1; Highly pathogenic avian influenza virus; Vaccine; Virulence
المشرفين على المادة: 0 (Antigens, Viral)
0 (Hemagglutinin Glycoproteins, Influenza Virus)
تواريخ الأحداث: Date Created: 20200603 Date Completed: 20210127 Latest Revision: 20220216
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7262163
DOI: 10.1007/s11262-020-01765-1
PMID: 32483655
قاعدة البيانات: MEDLINE
الوصف
تدمد:1572-994X
DOI:10.1007/s11262-020-01765-1