دورية أكاديمية
Influenza A(H1N1)pdm09 But Not A(H3N2) Virus Infection Induces Durable Seroprotection: Results From the Ha Nam Cohort.
| العنوان: | Influenza A(H1N1)pdm09 But Not A(H3N2) Virus Infection Induces Durable Seroprotection: Results From the Ha Nam Cohort. |
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| المؤلفون: | Hoa LNM; Oxford University Clinical Research Unit and Wellcome Trust Major Overseas Programme, Hanoi, Viet Nam., Sullivan SG; WHO Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.; Doherty Department, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.; Fielding School of Public Health, University of California, Los Angeles, California, USA., Mai LQ; National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam., Khvorov A; Doherty Department, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia., Phuong HVM; National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam., Hang NLK; National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam., Thai PQ; National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam., Thanh LT; National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam., Carolan L; WHO Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia., Anh DD; National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam., Duong TN; National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam., Bryant JE; Oxford University Clinical Research Unit and Wellcome Trust Major Overseas Programme, Hanoi, Viet Nam.; Center for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., van Doorn HR; Oxford University Clinical Research Unit and Wellcome Trust Major Overseas Programme, Hanoi, Viet Nam.; Center for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Wertheim HFL; Oxford University Clinical Research Unit and Wellcome Trust Major Overseas Programme, Hanoi, Viet Nam.; Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands., Horby P; Oxford University Clinical Research Unit and Wellcome Trust Major Overseas Programme, Hanoi, Viet Nam.; Center for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Fox A; Oxford University Clinical Research Unit and Wellcome Trust Major Overseas Programme, Hanoi, Viet Nam.; WHO Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia. |
| المصدر: | The Journal of infectious diseases [J Infect Dis] 2022 Aug 12; Vol. 226 (1), pp. 59-69. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Oxford : Oxford University Press Original Publication: 1904-2010 : Chicago, IL : University of Chicago Press |
| مواضيع طبية MeSH: | Influenza, Human*/epidemiology , Influenza A Virus, H1N1 Subtype* , Influenza Vaccines*, Humans ; Antibodies, Viral ; Influenza A Virus, H3N2 Subtype ; Hemagglutination Inhibition Tests |
| مستخلص: | Background: The extent to which influenza recurrence depends upon waning immunity from prior infection is undefined. We used antibody titers of Ha-Nam cohort participants to estimate protection curves and decay trajectories. Methods: Households (270) participated in influenza-like-illness (ILI) surveillance and provided blood at intervals spanning laboratory-confirmed virus transmission. Sera were tested in hemagglutination inhibition assay. Infection was defined as influenza virus-positive ILI and/or seroconversion. Median protective titers were estimated using scaled-logistic regression to model pretransmission titer against infection status in that season, limiting analysis to households with infection(s). Titers were modelled against month since infection using mixed-effects linear regression to estimate decay and when titers fell below protection thresholds. Results: From December 2008-2012, 295 and 314 participants were infected with H1N1pdm09-like and A/Perth/16/09-like (H3N2Pe09) viruses, respectively. The proportion protected rose more steeply with titer for H1N1pdm09 than for H3N2Pe09, and estimated 50% protection titers were 19.6 and 37.3, respectively. Postinfection titers started higher against H3N2Pe09 but decayed more steeply than against H1N1pdm09. Seroprotection was estimated to be sustained against H1N1pdm09 but to wane by 8-months for H3N2Pe09. Conclusions: Estimates indicate that infection induces durable seroprotection against H1N1pdm09 but not H3N2Pe09, which could in part account for the younger age of A(H1N1) versus A(H3N2) cases. Competing Interests: Potential conflicts of interest. All authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. (© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.) |
| معلومات مُعتمدة: | United Kingdom WT_ Wellcome Trust; 081613/Z/06/Z United Kingdom WT_ Wellcome Trust |
| فهرسة مساهمة: | Keywords: H1N1 subtype; H3N2 subtype; antibody; cohort studies; immunity; influenza A virus |
| المشرفين على المادة: | 0 (Antibodies, Viral) 0 (Influenza Vaccines) |
| تواريخ الأحداث: | Date Created: 20200603 Date Completed: 20221118 Latest Revision: 20221204 |
| رمز التحديث: | 20240829 |
| مُعرف محوري في PubMed: | PMC9373157 |
| DOI: | 10.1093/infdis/jiaa293 |
| PMID: | 32484513 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1537-6613 |
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| DOI: | 10.1093/infdis/jiaa293 |