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The Effect of Corrected Inflammation, Oxidative Stress and Endothelial Dysfunction on Fmd Levels in Patients with Selected Chronic Diseases: A Quasi-Experimental Study.

التفاصيل البيبلوغرافية
العنوان: The Effect of Corrected Inflammation, Oxidative Stress and Endothelial Dysfunction on Fmd Levels in Patients with Selected Chronic Diseases: A Quasi-Experimental Study.
المؤلفون: Yilmaz MI; Epigenetic Health Solutions, Unit of Nephrology, Ankara, Turkey. mahmutiyilmaz@yahoo.com., Romano M; Division of Paediatric Rheumatology, Victoria Children's Hospital, University of Western Ontario, London, ON, Canada.; Department of Rheumatology, Istituto Ortopedico Gaetano Pini, Milano, Italy., Basarali MK; Ankara Provincial Health Directorate, Department of Biochemistry, Ankara, Turkey., Elzagallaai A; Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada.; Department of Paediatrics, Victoria Children's Hospital, University of Western Ontario, London, Canada., Karaman M; Epigenetic Health Solutions, Unit of Nephrology, Ankara, Turkey., Demir Z; Epigenetic Health Solutions, Unit of Nephrology, Ankara, Turkey., Demir MF; Epigenetic Health Solutions, Unit of Nephrology, Ankara, Turkey., Akcay F; Epigenetic Health Solutions, Unit of Nephrology, Ankara, Turkey., Seyrek M; Medisante Health Clinic, Unit of Integrative Medicine, Ankara, Turkey., Haksever N; Department of Endocrinology, Yeditepe University, Istanbul, Turkey., Piskin D; Division of Paediatric Rheumatology, Victoria Children's Hospital, University of Western Ontario, London, ON, Canada., Cimaz R; Department of Rheumatology, Istituto Ortopedico Gaetano Pini, Milano, Italy.; Department of Clinical Sciences and Community Health, University of Milano, Milano, Italy., Rieder MJ; Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada.; Department of Paediatrics, Victoria Children's Hospital, University of Western Ontario, London, Canada., Demirkaya E; Division of Paediatric Rheumatology, Victoria Children's Hospital, University of Western Ontario, London, ON, Canada.
المصدر: Scientific reports [Sci Rep] 2020 Jun 02; Vol. 10 (1), pp. 9018. Date of Electronic Publication: 2020 Jun 02.
نوع المنشور: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Oxidative Stress*/drug effects , Oxidative Stress*/physiology, Antioxidants/*pharmacology , Endothelium, Vascular/*drug effects , Endothelium, Vascular/*physiopathology , Inflammation/*physiopathology, Adult ; Aged ; Arginine/analogs & derivatives ; Arginine/blood ; Atherosclerosis ; C-Reactive Protein/metabolism ; Chronic Disease ; Dietary Supplements ; Fatty Acids, Omega-3/pharmacology ; Female ; Humans ; Male ; Malondialdehyde/blood ; Middle Aged ; Morinda/chemistry ; Serum Amyloid P-Component/metabolism ; Vasodilation
مستخلص: While the pathophysiology of chronic disorders varies there are three basic mechanisms - inflammation, oxidative stress and endothelial dysfunction - that are common in many chronic diseases. However, the failure of these mechanisms to work synchronously can lead to morbidity complicating the course of many chronic diseases. We analyzed data of 178 patients from cohorts with selected chronic diseases in this quasi-experimental study. Endothelial dysfunction was determined by flow-mediated dilatation (FMD) and asymmetric dimethylarginine (ADMA) levels. Serum ADMA, high sensitive C-reactive protein (hs-CRP), serum PTX3, malondialdehyde (MDA), Cu/Zn-superoxide dismutase (Cu/Zn-SOD), glutathione peroxidase (GSH-Px) levels and FMD were studied in baseline and after 12 weeks of Morinda citrifolia (anti-atherosclerotic liquid- AAL), omega-3 (anti-inflammatory capsules- AIC) and extract with Alaskan blueberry (anti-oxidant liquid- AOL). Stepwise multivariate regression analysis was used to evaluate the association of FMD with clinical and serologic parameters. Serum ADMA, MDA, PTX3, hsCRP and albumin levels, and proteinuria were significantly decreased while CuZn-SOD, GSH-Px and FMD levels were significantly increased following AAL, AIC and AOL therapies. The FMD was negatively correlated with serum ADMA, MDA, PTX3, and hsCRP levels and positively correlated with CuZn-SOD and eGFR levels. ADMA and PTX3 levels were independently related to FMD both before and after AAL, AIC and AOL therapies. Our study shows that serum ADMA, MDA, PTX3 levels are associated with endothelial dysfunction in patients with selected chronic diseases. In addition, short-term AAL, AIC and AOL therapies significantly improves a number of parameters in our cohort and can normalize ADMA, PTX3, hsCRP and MDA levels.
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المشرفين على المادة: 0 (Antioxidants)
0 (Fatty Acids, Omega-3)
0 (Serum Amyloid P-Component)
148591-49-5 (PTX3 protein)
4Y8F71G49Q (Malondialdehyde)
63CV1GEK3Y (N,N-dimethylarginine)
9007-41-4 (C-Reactive Protein)
94ZLA3W45F (Arginine)
تواريخ الأحداث: Date Created: 20200604 Date Completed: 20201217 Latest Revision: 20210602
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC7265488
DOI: 10.1038/s41598-020-65528-6
PMID: 32488098
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-020-65528-6