دورية أكاديمية
Polymeric micelles loaded with carfilzomib increase tolerability in a humanized bone marrow-like scaffold mouse model.
العنوان: | Polymeric micelles loaded with carfilzomib increase tolerability in a humanized bone marrow-like scaffold mouse model. |
---|---|
المؤلفون: | Varela-Moreira A; Laboratory of Clinical Chemistry and Hematology (LKCH), University Medical Center Utrecht, Heidelberglaan 100, 3584, CX, Utrecht, the Netherlands.; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Faculty of Science, Utrecht University, Universiteitsweg 99, 3584, CG, Utrecht, the Netherlands., van Straten D; Laboratory of Clinical Chemistry and Hematology (LKCH), University Medical Center Utrecht, Heidelberglaan 100, 3584, CX, Utrecht, the Netherlands., van Leur HF; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Faculty of Science, Utrecht University, Universiteitsweg 99, 3584, CG, Utrecht, the Netherlands., Ruiter RWJ; Department of Hematology, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan 1118, 1182, DB, Amsterdam, the Netherlands., Deshantri AK; Laboratory of Clinical Chemistry and Hematology (LKCH), University Medical Center Utrecht, Heidelberglaan 100, 3584, CX, Utrecht, the Netherlands.; Biological Research Pharmacology Department, Sun Pharma Advanced Research Company Ltd., Vadodara, India., Hennink WE; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Faculty of Science, Utrecht University, Universiteitsweg 99, 3584, CG, Utrecht, the Netherlands., Fens MHAM; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Faculty of Science, Utrecht University, Universiteitsweg 99, 3584, CG, Utrecht, the Netherlands., Groen RWJ; Department of Hematology, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan 1118, 1182, DB, Amsterdam, the Netherlands., Schiffelers RM; Laboratory of Clinical Chemistry and Hematology (LKCH), University Medical Center Utrecht, Heidelberglaan 100, 3584, CX, Utrecht, the Netherlands.; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Faculty of Science, Utrecht University, Universiteitsweg 99, 3584, CG, Utrecht, the Netherlands. |
المصدر: | International journal of pharmaceutics: X [Int J Pharm X] 2020 May 16; Vol. 2, pp. 100049. Date of Electronic Publication: 2020 May 16 (Print Publication: 2020). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101753452 Publication Model: eCollection Cited Medium: Internet ISSN: 2590-1567 (Electronic) Linking ISSN: 25901567 NLM ISO Abbreviation: Int J Pharm X Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: [Amsterdam] : Elsevier B.V., [2019]- |
مستخلص: | Carfilzomib-loaded polymeric micelles (CFZ-PM) based on poly(ethylene glycol)-b-poly(N-2-benzoyloxypropyl methacrylamide) (mPEG-b-p(HPMA-Bz)) were prepared with the aim to improve the maximum tolerated dose of carfilzomib in a "humanized" bone marrow-like scaffold model. For this, CFZ-PM were prepared and characterized for their size, carfilzomib loading and cytotoxicity towards multiple myeloma cells. Further, circulation and tumor & tissue distribution of fluorescently labeled micelles were determined. Tolerability of CFZ-PM versus the clinical approved formulation - Kyprolis® - was assessed. CFZ-PM presented small diameter below 55 nm and low PDI < 0.1. Cy7-labeled micelles circulated for extended periods of time with over 80% of injected dose in circulation at 24 h after intravenous injection and 1.3% of the injected dose of Cy7-labeled micelles accumulated in myeloma tumor-bearing scaffolds. Importantly, CFZ-PM were well tolerated whereas Kyprolis® showed adverse effects. Kyprolis® dosed at the maximum tolerated dose, as well as CFZ-PM, did not show therapeutic benefit, while multiple myeloma cells showed sensitivity in vitro , underlining the importance of the bone marrow crosstalk in testing novel formulations. Overall, this work indicates that PM are potential drug carriers of carfilzomib. Competing Interests: The authors report no conflicts of interest. (© 2020 The Authors.) |
References: | Blood. 2012 Jul 19;120(3):e9-e16. (PMID: 22653974) Curr Pharm Des. 2015;21(14):1785-99. (PMID: 25738491) Joint Bone Spine. 2010 Jan;77(1):20-6. (PMID: 20031467) J Control Release. 2019 Feb 28;296:232-240. (PMID: 30682443) Br J Radiol. 2012 Jan;85(1009):81-92. (PMID: 22096219) Nephrol Dial Transplant. 2012 Oct;27(10):3713-8. (PMID: 23114897) J Control Release. 2012 Dec 28;164(3):346-54. (PMID: 22759979) J Clin Oncol. 2015 Mar 1;33(7):732-9. (PMID: 25225420) J Control Release. 2018 Oct 10;287:194-215. (PMID: 30165140) Biomacromolecules. 2017 May 8;18(5):1449-1459. (PMID: 28328191) Expert Opin Biol Ther. 2014 Nov;14(11):1685-99. (PMID: 25170966) Jpn J Clin Oncol. 2018 Sep 1;48(9):785-793. (PMID: 30102324) Drug Metab Dispos. 2011 Oct;39(10):1873-82. (PMID: 21752943) Biologics. 2013;7:13-32. (PMID: 23386784) Nat Rev Cancer. 2004 May;4(5):349-60. (PMID: 15122206) Leukemia. 2012 Jan;26(1):149-57. (PMID: 21799510) J Control Release. 2013 Dec 28;172(3):782-94. (PMID: 24075927) Acta Biomater. 2018 Oct 15;80:288-295. (PMID: 30240956) J Interferon Cytokine Res. 1999 May;19(5):533-41. (PMID: 10386866) Cancer Metastasis Rev. 2017 Dec;36(4):561-584. (PMID: 29196868) J Biomed Biotechnol. 2012;2012:157496. (PMID: 23093834) ACS Nano. 2015;9(4):3740-52. (PMID: 25831471) J Pharm Biomed Anal. 2016 May 30;124:365-373. (PMID: 26994320) Drug Metab Dispos. 2013 Jan;41(1):230-7. (PMID: 23118326) PLoS One. 2017 Mar 8;12(3):e0173247. (PMID: 28273121) J Control Release. 2017 Sep 28;262:47-57. (PMID: 28700897) Cancer Chemother Pharmacol. 2013 Oct;72(4):861-8. (PMID: 23975329) Eur J Pharm Biopharm. 2015 Aug;94:501-12. (PMID: 26134273) Clin Pharmacol. 2014 May 08;6:87-96. (PMID: 24855395) Acc Chem Res. 2013 Mar 19;46(3):761-9. (PMID: 23964655) Nat Nanotechnol. 2011 Oct 23;6(12):815-23. (PMID: 22020122) J Pharmacol Exp Ther. 2015 Nov;355(2):168-73. (PMID: 26311812) Leukemia. 2009 Mar;23(3):435-41. (PMID: 19039321) J Mater Sci Mater Med. 2002 Dec;13(12):1271-5. (PMID: 15348676) N Engl J Med. 2011 Mar 17;364(11):1046-60. (PMID: 21410373) Langmuir. 2018 Dec 18;34(50):15495-15506. (PMID: 30415546) Clin Cancer Res. 2013 Sep 1;19(17):4559-63. (PMID: 23775332) Expert Opin Drug Deliv. 2010 Jan;7(1):49-62. (PMID: 20017660) Tissue Eng Part A. 2009 Dec;15(12):3741-51. (PMID: 19519274) |
فهرسة مساهمة: | Keywords: Bone Marrow Microenvironment; Carfilzomib; Drug delivery; Multiple Myeloma; Polymeric micelles; Proteasome inhibitor |
تواريخ الأحداث: | Date Created: 20200604 Latest Revision: 20200928 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC7262453 |
DOI: | 10.1016/j.ijpx.2020.100049 |
PMID: | 32490374 |
قاعدة البيانات: | MEDLINE |
كن أول من يترك تعليقا!