دورية أكاديمية
أعرض في EDS

Sex-specific DNA methylation differences in people exposed to polybrominated biphenyl.

التفاصيل البيبلوغرافية
العنوان: Sex-specific DNA methylation differences in people exposed to polybrominated biphenyl.
المؤلفون: Curtis SW; Genetics & Molecular Biology Program, Laney Graduate School, Emory University School of Medicine, 101 Woodruff Circle NE, Ste 4217, Atlanta, GA 30322, USA., Gerkowicz SA; Department of Gynecology & Obstetrics, Emory University School of Medicine, 101 Woodruff Circle NE, Ste 4217, Atlanta, GA 30322, USA., Cobb DO; Department of Gynecology & Obstetrics, Emory University School of Medicine, 101 Woodruff Circle NE, Ste 4217, Atlanta, GA 30322, USA., Kilaru V; Department of Gynecology & Obstetrics, Emory University School of Medicine, 101 Woodruff Circle NE, Ste 4217, Atlanta, GA 30322, USA., Terrell ML; Department of Epidemiology, Emory University Rollins School of Public Health, 1518 Clifton Rd, Atlanta, GA 30322, USA., Marder ME; Department of Environmental Health, Emory University Rollins School of Public Health, 1518 Clifton Rd, Atlanta, GA 30322, USA., Barr DB; Department of Environmental Health, Emory University Rollins School of Public Health, 1518 Clifton Rd, Atlanta, GA 30322, USA., Marsit CJ; Department of Environmental Health, Emory University Rollins School of Public Health, 1518 Clifton Rd, Atlanta, GA 30322, USA., Marcus M; Department of Epidemiology, Emory University Rollins School of Public Health, 1518 Clifton Rd, Atlanta, GA 30322, USA.; Department of Pediatrics Emory University School of Medicine, 1518 Clifton Rd, Atlanta, GA 30322, USA., Conneely KN; Department of Human Genetics, Emory University School of Medicine, 615 Michael St, Atlanta, GA 30322, USA., Smith AK; Department of Gynecology & Obstetrics, Emory University School of Medicine, 101 Woodruff Circle NE, Ste 4217, Atlanta, GA 30322, USA.; Department of Psychiatry & Behavioral Science, Emory University School of Medicine, 101 Woodruff Circle NE, Ste 4217, Atlanta, GA 30322, USA.
المصدر: Epigenomics [Epigenomics] 2020 May; Vol. 12 (9), pp. 757-770. Date of Electronic Publication: 2020 Jun 04.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Future Medicine Country of Publication: England NLM ID: 101519720 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1750-192X (Electronic) Linking ISSN: 1750192X NLM ISO Abbreviation: Epigenomics Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Future Medicine, 2009-
مواضيع طبية MeSH: DNA Methylation* , Sex Characteristics*, Polybrominated Biphenyls/*toxicity, Adult ; Aged ; Aged, 80 and over ; Binding Sites ; CpG Islands ; Environmental Exposure ; Female ; Humans ; Male ; Middle Aged ; Transcription Factors/metabolism ; Young Adult
مستخلص: Aim: Michigan residents were exposed to polybrominated biphenyls (PBBs) when it was accidentally added to the food supply. Highly exposed individuals report sex-specific health problems, but the underlying biological mechanism behind these different health risks is not known. Materials and methods: DNA methylation in blood from 381 women and 277 men with PBB exposure was analyzed with the MethylationEPIC BeadChip. Results: 675 CpGs were associated with PBBs levels in males, while only 17 CpGs were associated in females (false discovery rate <0.05). No CpGs were associated in both sexes. These CpGs were enriched in different functional regions and transcription factor binding sites in each sex. Conclusion: Exposure to PBBs may have sex-specific effects on the epigenome that may underlie sex-specific adverse health outcomes.
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معلومات مُعتمدة: R01 ES024790 United States ES NIEHS NIH HHS; UL1 TR002378 United States TR NCATS NIH HHS; T32 GM008490 United States GM NIGMS NIH HHS; P30 ES019776 United States ES NIEHS NIH HHS; R01 ES025775 United States ES NIEHS NIH HHS; R24 ES028528 United States ES NIEHS NIH HHS
فهرسة مساهمة: Keywords: DNA methylation; EDC; EWAS; endocrine-disrupting compound; environmental health; epigenetics; epigenome-wide association study; polybrominated biphenyl; sex differences; sex specific
المشرفين على المادة: 0 (Polybrominated Biphenyls)
0 (Transcription Factors)
تواريخ الأحداث: Date Created: 20200605 Date Completed: 20210810 Latest Revision: 20210810
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC7607410
DOI: 10.2217/epi-2019-0179
PMID: 32496131
قاعدة البيانات: MEDLINE
الوصف
تدمد:1750-192X
DOI:10.2217/epi-2019-0179