دورية أكاديمية
The Natural History and Transmission Potential of Asymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Infection.
| العنوان: | The Natural History and Transmission Potential of Asymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Infection. |
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| المؤلفون: | Van Vinh Chau N; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Lam VT; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Dung NT; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Yen LM; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Minh NNQ; Children's Hospital 1, Ho Chi Minh City, Vietnam., Hung LM; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Ngoc NM; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Dung NT; Center for Disease Control and Prevention, Ho Chi Minh City, Vietnam., Man DNH; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Nguyet LA; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Nhat LTH; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Nhu LNT; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Ny NTH; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Hong NTT; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Kestelyn E; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Dung NTP; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Xuan TC; Cu Chi Hospital, Ho Chi Minh City, Vietnam., Hien TT; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Phong NT; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Tu TNH; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Geskus RB; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Thanh TT; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Truong NT; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Binh NT; Department of Health, Ho Chi Minh City, Vietnam., Thuong TC; Department of Health, Ho Chi Minh City, Vietnam., Thwaites G; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Van Tan L; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam. |
| مؤلفون مشاركون: | Oxford University Clinical Research Unit COVID-19 Research Group |
| المصدر: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2020 Dec 17; Vol. 71 (10), pp. 2679-2687. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 9203213 Publication Model: Print Cited Medium: Internet ISSN: 1537-6591 (Electronic) Linking ISSN: 10584838 NLM ISO Abbreviation: Clin Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Oxford : Oxford University Press Original Publication: Chicago, IL : The University of Chicago Press, c1992- |
| مواضيع طبية MeSH: | COVID-19* , SARS-CoV-2*, Humans ; Prospective Studies ; RNA, Viral ; Vietnam/epidemiology |
| مستخلص: | Background: Little is known about the natural history of asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods: We conducted a prospective study at a quarantine center for coronavirus disease 2019 in Ho Chi Minh City, Vietnam. We enrolled quarantined people with reverse-transcription polymerase chain reaction (RT-PCR)-confirmed SARS-CoV-2 infection, collecting clinical data, travel and contact history, and saliva at enrollment and daily nasopharyngeal/throat swabs (NTSs) for RT-PCR testing. We compared the natural history and transmission potential of asymptomatic and symptomatic individuals. Results: Between 10 March and 4 April 2020, 14 000 quarantined people were tested for SARS-CoV-2; 49 were positive. Of these, 30 participated in the study: 13 (43%) never had symptoms and 17 (57%) were symptomatic. Seventeen (57%) participants imported cases. Compared with symptomatic individuals, asymptomatic people were less likely to have detectable SARS-CoV-2 in NTS collected at enrollment (8/13 [62%] vs 17/17 [100%]; P = .02). SARS-CoV-2 RNA was detected in 20 of 27 (74%) available saliva samples (7 of 11 [64%] in the asymptomatic group and 13 of 16 [81%] in the symptomatic group; P = .56). Analysis of RT-PCR positivity probability showed that asymptomatic participants had faster viral clearance than symptomatic participants (P < .001 for difference over the first 19 days). This difference was most pronounced during the first week of follow-up. Two of the asymptomatic individuals appeared to transmit SARS-CoV-2 to 4 contacts. Conclusions: Asymptomatic SARS-CoV-2 infection is common and can be detected by analysis of saliva or NTSs. The NTS viral loads fall faster in asymptomatic individuals, but these individuals appear able to transmit the virus to others. (© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.) |
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| معلومات مُعتمدة: | United Kingdom WT_ Wellcome Trust |
| فهرسة مساهمة: | Investigator: N Van Vinh Chau; NT Dung; LM Hung; HT Loan; NT Truong; NT Phong; DNH Man; N Van Hao; DB Thuy; NM Ngoc; NPH Lan; PTN Thoa; TNP Thao; TTL Phuong; LTT Uyen; TTT Tam; BTT That; HK Nhung; NT Tai; TNH Tu; VT Vuong; DTB Ty; LT Dung; TL Uyen; NTM Tien; HTT Thao; NN Thao; HNT Vuong; PNP Thao; PM Phuong; DTH Tam; E Kestelyn; D Joseph; R Geskus; G Thwaites; HR van Doorn; H Van Hien; HLA Huy; HN Ha; HX Yen; J Van Nuil; J Day; J Donovan; K Lawson; LA Nguyet; LM Yen; LNT Nhu; LTH Nhat; L Van Tan; SL Odette; L Thwaites; M Rabaa; M Choisy; M Chambers; M Rahman; NT Hoa; NTT Nhien; NTH Ny; NTK Tuyen; NTP Dung; NTT Hong; NX Truong; PNQ Khanh; PLK Yen; S Yacoub; T Kesteman; NTT Thuong; TT Thanh; TT Hien; VTT Hang; NT Dung; LH Nga Keywords: COVID-19; SARS-CoV-2; Vietnam; coronaviruses; pandemic |
| المشرفين على المادة: | 0 (RNA, Viral) |
| تواريخ الأحداث: | Date Created: 20200605 Date Completed: 20210325 Latest Revision: 20231110 |
| رمز التحديث: | 20231110 |
| مُعرف محوري في PubMed: | PMC7314145 |
| DOI: | 10.1093/cid/ciaa711 |
| PMID: | 32497212 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1537-6591 |
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| DOI: | 10.1093/cid/ciaa711 |