دورية أكاديمية
Dysregulation in the expression of (lncRNA-TSIX, TP53INP2 mRNA, miRNA-1283) in spinal cord injury.
| العنوان: | Dysregulation in the expression of (lncRNA-TSIX, TP53INP2 mRNA, miRNA-1283) in spinal cord injury. |
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| المؤلفون: | Salah SMM; Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Matboli M; Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Electronic address: DrMarwa__Matboly@med.asu.edu.eg., Nasser HE; Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Abdelnaiem IA; NeurosurgeryDepartment, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Shafei AE; Armed Forces College of Medicine, Cairo, Egypt., El-Asmer MF; Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. |
| المصدر: | Genomics [Genomics] 2020 Sep; Vol. 112 (5), pp. 3315-3321. Date of Electronic Publication: 2020 Jun 11. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: United States NLM ID: 8800135 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8646 (Electronic) Linking ISSN: 08887543 NLM ISO Abbreviation: Genomics Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: San Diego : Academic Press, [c1987- |
| مواضيع طبية MeSH: | MicroRNAs/*blood , Nuclear Proteins/*genetics , RNA, Long Noncoding/*blood , Spinal Cord Injuries/*genetics, Adult ; Female ; Gene Expression Regulation ; Humans ; Male ; Middle Aged ; Nuclear Proteins/blood ; Pilot Projects ; RNA, Messenger/blood ; Spinal Cord Injuries/blood ; Spinal Cord Injuries/diagnosis ; Spinal Cord Injuries/pathology |
| مستخلص: | Aim: The objective of this study is to examine the alterations in the levels of expression of serum lncRNA-TSIX, TP53INP2 mRNA, miRNA-1283 in spinal cord injured (SCI) patients versus healthy control. Method: The expression of the selected RNAs in the sera was determined in 23 patients suffering from acute spinal cord injury, 41 individuals with chronic spinal cord injury, and 36 healthy control using real-time reverse-transcription polymerase chain reaction method. Results: The results showed that lncRNA-TSIX and the TP53INP2 mRNA expression levels in SCI patients was overexpressed in comparison to the control group alongside with a significant downregulation of miR-1283. Statistically,there was a highly significant positive correlation between lnc-RNA-TRIX and TP53INP2 mRNA with inverse correlation between miRNA-1283 and lnc-RNA-TRIX based on fold changes. Conclusion: Up-regulation of lncRNA-TSIX, TP53INP2 mRNA with downregulation of miRNA-1283 might be closely associated with progression of SCI. Competing Interests: Declaration of Competing Interest All the study authors declared no remarkable conflicts throughout the study. (Copyright © 2020. Published by Elsevier Inc.) |
| فهرسة مساهمة: | Keywords: Serum; Spinal cord injury; lncRNA; mRNA; miRNA |
| المشرفين على المادة: | 0 (MIRN1283 microRNA, human) 0 (MicroRNAs) 0 (Nuclear Proteins) 0 (RNA, Long Noncoding) 0 (RNA, Messenger) 0 (TP53INP2 protein, human) 0 (TSIX long non-coding RNA, human) |
| تواريخ الأحداث: | Date Created: 20200615 Date Completed: 20210816 Latest Revision: 20210816 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.ygeno.2020.06.018 |
| PMID: | 32535070 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1089-8646 |
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| DOI: | 10.1016/j.ygeno.2020.06.018 |