دورية أكاديمية

Innate Allorecognition and Memory in Transplantation.

التفاصيل البيبلوغرافية
العنوان: Innate Allorecognition and Memory in Transplantation.
المؤلفون: Zhao D; Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, United States.; Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Abou-Daya KI; Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, United States., Dai H; Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, United States., Oberbarnscheidt MH; Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, United States.; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, United States.; Department of Critical Care Medicine, Center for Critical Care Nephrology, University of Pittsburgh, Pittsburgh, PA, United States., Li XC; Immunobiology & Transplant Science Center and Department of Surgery, Houston Methodist Hospital, Texas Medical Center, Houston, TX, United States., Lakkis FG; Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, United States.; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, United States.; Department of Medicine, Renal-Electrolyte Division, University of Pittsburgh, Pittsburgh, PA, United States.
المصدر: Frontiers in immunology [Front Immunol] 2020 May 28; Vol. 11, pp. 918. Date of Electronic Publication: 2020 May 28 (Print Publication: 2020).
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Lausanne : Frontiers Research Foundation]
مواضيع طبية MeSH: Graft Survival*/drug effects , Immunity, Innate*/drug effects , Immunologic Memory*/drug effects , Transplantation Tolerance*/drug effects, Graft Rejection/*immunology , Isoantigens/*immunology , Organ Transplantation/*adverse effects, Animals ; Graft Rejection/prevention & control ; Histocompatibility Antigens Class I/immunology ; Humans ; Immunosuppressive Agents/therapeutic use ; Treatment Outcome
مستخلص: Over the past few decades, we have witnessed a decline in the rates of acute rejection without significant improvement in chronic rejection. Current treatment strategies principally target the adaptive immune response and not the innate response. Therefore, better understanding of innate immunity in transplantation and how to target it is highly desirable. Here, we review the latest advances in innate immunity in transplantation focusing on the roles and mechanisms of innate allorecognition and memory in myeloid cells. These novel concepts could explain why alloimmune response do not abate over time and shed light on new molecular pathways that can be interrupted to prevent or treat chronic rejection.
(Copyright © 2020 Zhao, Abou-Daya, Dai, Oberbarnscheidt, Li and Lakkis.)
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معلومات مُعتمدة: R01 AI099465 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: allorecognition; dendritic cell; innate immunity; monocyte; transplantation
المشرفين على المادة: 0 (Histocompatibility Antigens Class I)
0 (Immunosuppressive Agents)
0 (Isoantigens)
تواريخ الأحداث: Date Created: 20200618 Date Completed: 20210406 Latest Revision: 20210407
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7270276
DOI: 10.3389/fimmu.2020.00918
PMID: 32547540
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-3224
DOI:10.3389/fimmu.2020.00918